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Bisphosphonate - Induced Nephropathy

MedGen UID:
883247
•Concept ID:
C4055379
•
Disease or Syndrome

Definition

Kidney damage resulting from exposure to bisphosphonates. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBisphosphonate - Induced Nephropathy

Professional guidelines

PubMed

Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article
Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays.
Brown JP, Morin S, Leslie W, Papaioannou A, Cheung AM, Davison KS, Goltzman D, Hanley DA, Hodsman A, Josse R, Jovaisas A, Juby A, Kaiser S, Karaplis A, Kendler D, Khan A, Ngui D, Olszynski W, Ste-Marie LG, Adachi J
Can Fam Physician 2014 Apr;60(4):324-33. PMID: 24733321Free PMC Article
Osteoporosis treatment: focus on safety.
Reid IR
Eur J Intern Med 2013 Dec;24(8):691-7. Epub 2013 Apr 19 doi: 10.1016/j.ejim.2013.03.012. PMID: 23608531

Recent clinical studies

Etiology

Efficacy and safety of medications for osteoporosis in kidney transplant recipients or patients with chronic kidney disease: A meta-analysis.
Leng Y, Yu X, Yang Y, Xia Y
J Investig Med 2023 Oct;71(7):760-772. Epub 2023 Jun 30 doi: 10.1177/10815589231184215. PMID: 37387531
Medication safety in chronic kidney disease.
Singh S
Curr Opin Nephrol Hypertens 2023 Sep 1;32(5):434-438. Epub 2023 Jun 8 doi: 10.1097/MNH.0000000000000907. PMID: 37382164
Hypocalcemia Risk of Denosumab Across the Spectrum of Kidney Disease: A Population-Based Cohort Study.
Cowan A, Jeyakumar N, McArthur E, Fleet JL, Kanagalingam T, Karp I, Khan T, Muanda FT, Nash DM, Silver SA, Thain J, Weir MA, Garg AX, Clemens KK
J Bone Miner Res 2023 May;38(5):650-658. Epub 2023 Apr 9 doi: 10.1002/jbmr.4804. PMID: 36970786
Drug-induced nephrotoxicity.
Sales GTM, Foresto RD
Rev Assoc Med Bras (1992) 2020 Jan 13;66Suppl 1(Suppl 1):s82-s90. doi: 10.1590/1806-9282.66.S1.82. PMID: 31939540
Bisphosphonate drug holidays--when, why and for how long?
Anagnostis P, Stevenson JC
Climacteric 2015;18 Suppl 2:32-8. Epub 2015 Oct 27 doi: 10.3109/13697137.2015.1099092. PMID: 26507608

Diagnosis

Drug-induced nephrotoxicity.
Sales GTM, Foresto RD
Rev Assoc Med Bras (1992) 2020 Jan 13;66Suppl 1(Suppl 1):s82-s90. doi: 10.1590/1806-9282.66.S1.82. PMID: 31939540
Low Bone Density and Bisphosphonate Use and the Risk of Kidney Stones.
Prochaska M, Taylor E, Vaidya A, Curhan G
Clin J Am Soc Nephrol 2017 Aug 7;12(8):1284-1290. Epub 2017 Jun 2 doi: 10.2215/CJN.01420217. PMID: 28576907Free PMC Article
Drug-induced glomerular disease: direct cellular injury.
Markowitz GS, Bomback AS, Perazella MA
Clin J Am Soc Nephrol 2015 Jul 7;10(7):1291-9. Epub 2015 Apr 10 doi: 10.2215/CJN.00860115. PMID: 25862776Free PMC Article
Targeted microbubbles: a novel application for the treatment of kidney stones.
Ramaswamy K, Marx V, Laser D, Kenny T, Chi T, Bailey M, Sorensen MD, Grubbs RH, Stoller ML
BJU Int 2015 Jul;116(1):9-16. Epub 2015 Mar 17 doi: 10.1111/bju.12996. PMID: 25402588Free PMC Article
Renal osteodystrophy and hypercalcemia.
Cohen-Solal M, Sebert JL
Curr Opin Rheumatol 1993 May;5(3):357-62. doi: 10.1097/00002281-199305030-00016. PMID: 8512774

Therapy

Medication safety in chronic kidney disease.
Singh S
Curr Opin Nephrol Hypertens 2023 Sep 1;32(5):434-438. Epub 2023 Jun 8 doi: 10.1097/MNH.0000000000000907. PMID: 37382164
Hypocalcemia Risk of Denosumab Across the Spectrum of Kidney Disease: A Population-Based Cohort Study.
Cowan A, Jeyakumar N, McArthur E, Fleet JL, Kanagalingam T, Karp I, Khan T, Muanda FT, Nash DM, Silver SA, Thain J, Weir MA, Garg AX, Clemens KK
J Bone Miner Res 2023 May;38(5):650-658. Epub 2023 Apr 9 doi: 10.1002/jbmr.4804. PMID: 36970786
Bisphosphonate nephropathy: A case series and review of the literature.
de Roij van Zuijdewijn C, van Dorp W, Florquin S, Roelofs J, Verburgh K
Br J Clin Pharmacol 2021 Sep;87(9):3485-3491. Epub 2021 Mar 4 doi: 10.1111/bcp.14780. PMID: 33595131Free PMC Article
Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article
Bisphosphonate nephrotoxicity.
Perazella MA, Markowitz GS
Kidney Int 2008 Dec;74(11):1385-93. Epub 2008 Aug 6 doi: 10.1038/ki.2008.356. PMID: 18685574

Prognosis

Hypocalcemia Risk of Denosumab Across the Spectrum of Kidney Disease: A Population-Based Cohort Study.
Cowan A, Jeyakumar N, McArthur E, Fleet JL, Kanagalingam T, Karp I, Khan T, Muanda FT, Nash DM, Silver SA, Thain J, Weir MA, Garg AX, Clemens KK
J Bone Miner Res 2023 May;38(5):650-658. Epub 2023 Apr 9 doi: 10.1002/jbmr.4804. PMID: 36970786
Low Bone Density and Bisphosphonate Use and the Risk of Kidney Stones.
Prochaska M, Taylor E, Vaidya A, Curhan G
Clin J Am Soc Nephrol 2017 Aug 7;12(8):1284-1290. Epub 2017 Jun 2 doi: 10.2215/CJN.01420217. PMID: 28576907Free PMC Article
Bone Metastasis from Renal Cell Carcinoma.
Chen SC, Kuo PL
Int J Mol Sci 2016 Jun 22;17(6) doi: 10.3390/ijms17060987. PMID: 27338367Free PMC Article
Drug-induced glomerular disease: direct cellular injury.
Markowitz GS, Bomback AS, Perazella MA
Clin J Am Soc Nephrol 2015 Jul 7;10(7):1291-9. Epub 2015 Apr 10 doi: 10.2215/CJN.00860115. PMID: 25862776Free PMC Article
Safety considerations with bisphosphonates for the treatment of osteoporosis.
Strampel W, Emkey R, Civitelli R
Drug Saf 2007;30(9):755-63. doi: 10.2165/00002018-200730090-00003. PMID: 17722968

Clinical prediction guides

Efficacy and safety of medications for osteoporosis in kidney transplant recipients or patients with chronic kidney disease: A meta-analysis.
Leng Y, Yu X, Yang Y, Xia Y
J Investig Med 2023 Oct;71(7):760-772. Epub 2023 Jun 30 doi: 10.1177/10815589231184215. PMID: 37387531
Hypocalcemia Risk of Denosumab Across the Spectrum of Kidney Disease: A Population-Based Cohort Study.
Cowan A, Jeyakumar N, McArthur E, Fleet JL, Kanagalingam T, Karp I, Khan T, Muanda FT, Nash DM, Silver SA, Thain J, Weir MA, Garg AX, Clemens KK
J Bone Miner Res 2023 May;38(5):650-658. Epub 2023 Apr 9 doi: 10.1002/jbmr.4804. PMID: 36970786
Bisphosphonate drug holidays--when, why and for how long?
Anagnostis P, Stevenson JC
Climacteric 2015;18 Suppl 2:32-8. Epub 2015 Oct 27 doi: 10.3109/13697137.2015.1099092. PMID: 26507608
Spontaneous fracture: multiple causes.
Wick JY
Consult Pharm 2009 Feb;24(2):100-2, 105-8, 110-2. doi: 10.4140/tcp.n.2009.100. PMID: 19275452
The safety of zoledronic acid.
Lipton A
Expert Opin Drug Saf 2007 May;6(3):305-13. doi: 10.1517/14740338.6.3.305. PMID: 17480179

Recent systematic reviews

Bisphosphonates for prevention of osteopenia in kidney-transplant recipients: a systematic review of randomized controlled trials.
Wang J, Yao M, Xu JH, Shu B, Wang YJ, Cui XJ
Osteoporos Int 2016 May;27(5):1683-90. Epub 2016 Jan 5 doi: 10.1007/s00198-015-3465-7. PMID: 26733377
Association of Drug Effects on Serum Parathyroid Hormone, Phosphorus, and Calcium Levels With Mortality in CKD: A Meta-analysis.
Palmer SC, Teixeira-Pinto A, Saglimbene V, Craig JC, Macaskill P, Tonelli M, de Berardis G, Ruospo M, Strippoli GF
Am J Kidney Dis 2015 Dec;66(6):962-71. Epub 2015 May 21 doi: 10.1053/j.ajkd.2015.03.036. PMID: 26003472
Prevention of steroid-induced low bone mineral density in children with renal diseases: a systematic review.
Gruppen MP, Davin JC, Oosterveld MJ, Schreuder MF, Dorresteijn EM, Kramer SP, Bouts AH
Nephrol Dial Transplant 2013 Aug;28(8):2099-106. Epub 2013 May 2 doi: 10.1093/ndt/gft090. PMID: 23640430
Interventions for preventing bone disease in kidney transplant recipients.
Palmer SC, McGregor DO, Strippoli GF
Cochrane Database Syst Rev 2007 Jul 18;(3):CD005015. doi: 10.1002/14651858.CD005015.pub3. PMID: 17636784

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