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Peritumoral Brain Edema

MedGen UID:
887794
•Concept ID:
C4054192
•
Finding
Synonym: PTBE

Definition

An intracranial edema that develops around a tumor in the meninges or brain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeritumoral Brain Edema

Professional guidelines

PubMed

Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment.
Fiani B, Jarrah R, Bhandarkar AR, De Stefano F, Amare A, Aljameey UA, Reardon T
Clin Transl Oncol 2023 Apr;25(4):866-872. Epub 2022 Nov 24 doi: 10.1007/s12094-022-03009-0. PMID: 36427121
Glucocorticoids in the management of peritumoral brain edema: a review of molecular mechanisms.
Murayi R, Chittiboina P
Childs Nerv Syst 2016 Dec;32(12):2293-2302. Epub 2016 Sep 9 doi: 10.1007/s00381-016-3240-x. PMID: 27613642Free PMC Article
Secretory Meningiomas: Characteristic Features and Clinical Management of a Unique Subgroup.
Mohme M, Emami P, Matschke J, Regelsberger J, Westphal M, Eicker SO
Neurosurg Clin N Am 2016 Apr;27(2):181-7. Epub 2016 Feb 19 doi: 10.1016/j.nec.2015.11.001. PMID: 27012382

Recent clinical studies

Etiology

Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy.
Hua YC, Gao DZ, Wang KY, Ding XS, Xu WR, Li YB, Shi WW, Sun SB, Li XY
Thorac Cancer 2023 Nov;14(31):3133-3139. Epub 2023 Sep 17 doi: 10.1111/1759-7714.15106. PMID: 37718465Free PMC Article
Peritumoral T2/FLAIR hyperintense MRI findings of meningiomas are not necessarily edema and may persist permanently: a systematic review.
Laajava J, Korja M
Neurosurg Rev 2023 Aug 5;46(1):193. doi: 10.1007/s10143-023-02094-1. PMID: 37541985Free PMC Article
Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment.
Fiani B, Jarrah R, Bhandarkar AR, De Stefano F, Amare A, Aljameey UA, Reardon T
Clin Transl Oncol 2023 Apr;25(4):866-872. Epub 2022 Nov 24 doi: 10.1007/s12094-022-03009-0. PMID: 36427121
Peritumoral Brain Edema and Surgical Outcome in Secretory Meningiomas: A Matched-Cohort Analysis.
Trivedi MM, Worley S, Raghavan A, Das P, Recinos PF, Barnett GH, Kshettry VR
World Neurosurg 2021 Jan;145:e170-e176. Epub 2020 Oct 3 doi: 10.1016/j.wneu.2020.09.151. PMID: 33022430
Vascularity of meningiomas.
Ansari SF, Shah KJ, Hassaneen W, Cohen-Gadol AA
Handb Clin Neurol 2020;169:153-165. doi: 10.1016/B978-0-12-804280-9.00010-X. PMID: 32553286

Diagnosis

Sphenoid wing meningiomas: peritumoral brain edema as a prognostic factor in surgical outcome.
Nassar A, Smolanka V, Smolanka A, Chaulagain D, Devinyak O
Neurosurg Rev 2022 Aug;45(4):2951-2959. Epub 2022 May 27 doi: 10.1007/s10143-022-01816-1. PMID: 35624342
Predictive Factors of Postoperative Peritumoral Brain Edema after Meningioma Resection.
Li LM, Zheng WJ, Chen YZ, Hu ZH, Liao W, Lin QC, Zhu YH, Huang HT, Lin SH, Gong J
Neurol India 2021 Nov-Dec;69(6):1682-1687. doi: 10.4103/0028-3886.333500. PMID: 34979669
Effect of Piezo1 Overexpression on Peritumoral Brain Edema in Glioblastomas.
Qu S, Hu T, Qiu O, Su Y, Gu J, Xia Z
AJNR Am J Neuroradiol 2020 Aug;41(8):1423-1429. Epub 2020 Jul 16 doi: 10.3174/ajnr.A6638. PMID: 32675337Free PMC Article
Vascularity of meningiomas.
Ansari SF, Shah KJ, Hassaneen W, Cohen-Gadol AA
Handb Clin Neurol 2020;169:153-165. doi: 10.1016/B978-0-12-804280-9.00010-X. PMID: 32553286
Rapid and Accurate MRI Segmentation of Peritumoral Brain Edema in Meningiomas.
Latini F, Larsson EM, Ryttlefors M
Clin Neuroradiol 2017 Jun;27(2):145-152. Epub 2015 Nov 24 doi: 10.1007/s00062-015-0481-0. PMID: 26603998

Therapy

Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy.
Hua YC, Gao DZ, Wang KY, Ding XS, Xu WR, Li YB, Shi WW, Sun SB, Li XY
Thorac Cancer 2023 Nov;14(31):3133-3139. Epub 2023 Sep 17 doi: 10.1111/1759-7714.15106. PMID: 37718465Free PMC Article
Systemic therapy for relapsed/refractory meningioma: Is there potential for antiangiogenic agents?
Dasanu CA, Samara Y, Codreanu I, Limonadi FM, Hamid O, Alvarez-Argote J
J Oncol Pharm Pract 2019 Apr;25(3):638-647. Epub 2018 Sep 26 doi: 10.1177/1078155218799850. PMID: 30253729
Rapid and Accurate MRI Segmentation of Peritumoral Brain Edema in Meningiomas.
Latini F, Larsson EM, Ryttlefors M
Clin Neuroradiol 2017 Jun;27(2):145-152. Epub 2015 Nov 24 doi: 10.1007/s00062-015-0481-0. PMID: 26603998
Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy.
Hou J, Kshettry VR, Selman WR, Bambakidis NC
Neurosurg Focus 2013 Dec;35(6):E2. doi: 10.3171/2013.8.FOCUS13301. PMID: 24289127
Corticorelin acetate injections for the treatment of peritumoral brain edema.
Moliterno JA, Henry E, Pannullo SC
Expert Opin Investig Drugs 2009 Sep;18(9):1413-9. doi: 10.1517/13543780903190689. PMID: 19678803

Prognosis

Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment.
Fiani B, Jarrah R, Bhandarkar AR, De Stefano F, Amare A, Aljameey UA, Reardon T
Clin Transl Oncol 2023 Apr;25(4):866-872. Epub 2022 Nov 24 doi: 10.1007/s12094-022-03009-0. PMID: 36427121
Sphenoid wing meningiomas: peritumoral brain edema as a prognostic factor in surgical outcome.
Nassar A, Smolanka V, Smolanka A, Chaulagain D, Devinyak O
Neurosurg Rev 2022 Aug;45(4):2951-2959. Epub 2022 May 27 doi: 10.1007/s10143-022-01816-1. PMID: 35624342
Predictive Factors of Postoperative Peritumoral Brain Edema after Meningioma Resection.
Li LM, Zheng WJ, Chen YZ, Hu ZH, Liao W, Lin QC, Zhu YH, Huang HT, Lin SH, Gong J
Neurol India 2021 Nov-Dec;69(6):1682-1687. doi: 10.4103/0028-3886.333500. PMID: 34979669
Effect of Piezo1 Overexpression on Peritumoral Brain Edema in Glioblastomas.
Qu S, Hu T, Qiu O, Su Y, Gu J, Xia Z
AJNR Am J Neuroradiol 2020 Aug;41(8):1423-1429. Epub 2020 Jul 16 doi: 10.3174/ajnr.A6638. PMID: 32675337Free PMC Article
Supportive care in neurooncology.
Pace A, Metro G, Fabi A
Curr Opin Oncol 2010 Nov;22(6):621-6. doi: 10.1097/CCO.0b013e32833e078c. PMID: 20706120

Clinical prediction guides

Bevacizumab reduces peritumoral brain edema in lung cancer brain metastases after radiotherapy.
Hua YC, Gao DZ, Wang KY, Ding XS, Xu WR, Li YB, Shi WW, Sun SB, Li XY
Thorac Cancer 2023 Nov;14(31):3133-3139. Epub 2023 Sep 17 doi: 10.1111/1759-7714.15106. PMID: 37718465Free PMC Article
Peritumoral T2/FLAIR hyperintense MRI findings of meningiomas are not necessarily edema and may persist permanently: a systematic review.
Laajava J, Korja M
Neurosurg Rev 2023 Aug 5;46(1):193. doi: 10.1007/s10143-023-02094-1. PMID: 37541985Free PMC Article
Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search.
Schramm MWJ, Currie S, Lee MT, Livermore LJ, Solanki SP, Mathew RK, Wurdak H, Lorger M, Twelves C, Short SC, Chakrabarty A, Chumas P
J Neurooncol 2023 Feb;161(3):451-467. Epub 2023 Feb 9 doi: 10.1007/s11060-023-04246-1. PMID: 36757526Free PMC Article
Peritumoral edema in meningiomas: pathophysiology, predictors, and principles for treatment.
Fiani B, Jarrah R, Bhandarkar AR, De Stefano F, Amare A, Aljameey UA, Reardon T
Clin Transl Oncol 2023 Apr;25(4):866-872. Epub 2022 Nov 24 doi: 10.1007/s12094-022-03009-0. PMID: 36427121
Effect of Piezo1 Overexpression on Peritumoral Brain Edema in Glioblastomas.
Qu S, Hu T, Qiu O, Su Y, Gu J, Xia Z
AJNR Am J Neuroradiol 2020 Aug;41(8):1423-1429. Epub 2020 Jul 16 doi: 10.3174/ajnr.A6638. PMID: 32675337Free PMC Article

Recent systematic reviews

Peritumoral T2/FLAIR hyperintense MRI findings of meningiomas are not necessarily edema and may persist permanently: a systematic review.
Laajava J, Korja M
Neurosurg Rev 2023 Aug 5;46(1):193. doi: 10.1007/s10143-023-02094-1. PMID: 37541985Free PMC Article
Radiological Differentiation Between Intracranial Meningioma and Solitary Fibrous Tumor/Hemangiopericytoma: A Systematic Literature Review.
El-Abtah ME, Murayi R, Lee J, Recinos PF, Kshettry VR
World Neurosurg 2023 Feb;170:68-83. Epub 2022 Nov 18 doi: 10.1016/j.wneu.2022.11.062. PMID: 36403933
Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy.
Hou J, Kshettry VR, Selman WR, Bambakidis NC
Neurosurg Focus 2013 Dec;35(6):E2. doi: 10.3171/2013.8.FOCUS13301. PMID: 24289127

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