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Abnormality of the lymphatic system

MedGen UID:
892707
•Concept ID:
C4021976
•
Anatomical Abnormality
Synonyms: adenopathy; disease of lymphatic part of lymphoid system; disease of lympoid system; disease or disorder of lymphatic part of lymphoid system; disorder of lymph node and lymphatics; disorder of lymphatic part of lymphoid system; disorder of lymphatic system; disorder of lymphoid system; glands, swollen; Lymphatic disease; lymphatic disease; lymphatic disorder; lymphatic part of lymphoid system disease; lymphatic part of lymphoid system disease or disorder; lymphatic system disorder; lympoid system disease; swollen gland; swollen glands
 
HPO: HP:0100763
Monarch Initiative: MONDO:0005833

Definition

An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the lymphatic system

Professional guidelines

PubMed

Updated APSA Guidelines for the Management of Blunt Liver and Spleen Injuries.
Williams RF, Grewal H, Jamshidi R, Naik-Mathuria B, Price M, Russell RT, Vogel A, Notrica DM, Stylianos S, Petty J
J Pediatr Surg 2023 Aug;58(8):1411-1418. Epub 2023 Mar 23 doi: 10.1016/j.jpedsurg.2023.03.012. PMID: 37117078
Comparative pathophysiology and management of protein-losing enteropathy.
Craven MD, Washabau RJ
J Vet Intern Med 2019 Mar;33(2):383-402. Epub 2019 Feb 14 doi: 10.1111/jvim.15406. PMID: 30762910Free PMC Article
Normalization of the vasculature for treatment of cancer and other diseases.
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Physiol Rev 2011 Jul;91(3):1071-121. doi: 10.1152/physrev.00038.2010. PMID: 21742796Free PMC Article

Recent clinical studies

Etiology

Indocyanine green lymphography findings in older patients with lower limb lymphedema.
Yoshida S, Koshima I, Imai H, Sasaki A, Fujioka Y, Nagamatsu S, Yokota K, Harima M, Yamashita S, Tashiro K
J Vasc Surg Venous Lymphat Disord 2020 Mar;8(2):251-258. Epub 2019 Jun 21 doi: 10.1016/j.jvsv.2019.03.021. PMID: 31231056

Diagnosis

Indocyanine green lymphography findings in older patients with lower limb lymphedema.
Yoshida S, Koshima I, Imai H, Sasaki A, Fujioka Y, Nagamatsu S, Yokota K, Harima M, Yamashita S, Tashiro K
J Vasc Surg Venous Lymphat Disord 2020 Mar;8(2):251-258. Epub 2019 Jun 21 doi: 10.1016/j.jvsv.2019.03.021. PMID: 31231056
Variable clinical presentation in primary lymphoedema: report of two cases.
Ozyurt A, Sevinc E, Baykan A, Arslan D, Argun M, Pamukcu O, Uzum K
Clin Dysmorphol 2014 Jul;23(3):83-87. doi: 10.1097/MCD.0000000000000036. PMID: 24619057
Lymphedema tarda after liver transplantation: a case report and review of the literature.
Saab S, Nguyen S, Collins J, Kunder G, Busuttil RW
Exp Clin Transplant 2006 Dec;4(2):567-70. PMID: 17238860
Congenital generalized cystic lymphangiomatosis diagnosed by prenatal ultrasound.
Haeusler MC, Hofmann HM, Hoenigl W, Karpf EF, Rosenkranz W
Prenat Diagn 1990 Sep;10(9):617-21. doi: 10.1002/pd.1970100912. PMID: 2267241

Therapy

Indocyanine green lymphography findings in older patients with lower limb lymphedema.
Yoshida S, Koshima I, Imai H, Sasaki A, Fujioka Y, Nagamatsu S, Yokota K, Harima M, Yamashita S, Tashiro K
J Vasc Surg Venous Lymphat Disord 2020 Mar;8(2):251-258. Epub 2019 Jun 21 doi: 10.1016/j.jvsv.2019.03.021. PMID: 31231056
Primary lymphoedema at an unusual location triggered by nephrotic syndrome.
Tabel Y, Mungan I, Sigirci A, Gungor S
Ann Acad Med Singap 2009 Jul;38(7):636-3. PMID: 19652856
Lymphedema tarda after liver transplantation: a case report and review of the literature.
Saab S, Nguyen S, Collins J, Kunder G, Busuttil RW
Exp Clin Transplant 2006 Dec;4(2):567-70. PMID: 17238860

Prognosis

Indocyanine green lymphography findings in older patients with lower limb lymphedema.
Yoshida S, Koshima I, Imai H, Sasaki A, Fujioka Y, Nagamatsu S, Yokota K, Harima M, Yamashita S, Tashiro K
J Vasc Surg Venous Lymphat Disord 2020 Mar;8(2):251-258. Epub 2019 Jun 21 doi: 10.1016/j.jvsv.2019.03.021. PMID: 31231056
Asymptomatic solitary mediastinal cystic lymphangioma: a rare entity.
Misthos P, Sepsas E, Kokotsakis I, Skottis I
Asian Cardiovasc Thorac Ann 2006 Dec;14(6):476-8. doi: 10.1177/021849230601400607. PMID: 17130322

Clinical prediction guides

Indocyanine green lymphography findings in older patients with lower limb lymphedema.
Yoshida S, Koshima I, Imai H, Sasaki A, Fujioka Y, Nagamatsu S, Yokota K, Harima M, Yamashita S, Tashiro K
J Vasc Surg Venous Lymphat Disord 2020 Mar;8(2):251-258. Epub 2019 Jun 21 doi: 10.1016/j.jvsv.2019.03.021. PMID: 31231056

Supplemental Content

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      Clinical tests in GTR
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