U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal fundus autofluorescence imaging

MedGen UID:
892746
Concept ID:
C4073073
Finding
HPO: HP:0030602

Definition

Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Autofluorescent patterns result from the complex interaction of fluorophores such a lipofuscin, which release an autofluorescent signal, and elements such as melanin and rhodopsin, which absorb the excitation beam and attenuate autofluorescence. Other structures such as retinal vessels and the crystalline lens may also influence autofluorescence through blocking and interference. [from HPO]

Professional guidelines

PubMed

Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Sen M, Shields CL, Honavar SG, Shields JA
Indian J Ophthalmol 2019 Jun;67(6):763-771. doi: 10.4103/ijo.IJO_841_19. PMID: 31124484Free PMC Article
Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109Free PMC Article

Recent clinical studies

Etiology

Islam YFK, Khurshid SG
Curr Opin Ophthalmol 2022 Nov 1;33(6):525-531. Epub 2022 Jul 12 doi: 10.1097/ICU.0000000000000863. PMID: 35819905
Shrirao AB, Schloss RS, Fritz Z, Shrirao MV, Rosen R, Yarmush ML
Biotechnol Bioeng 2021 Dec;118(12):4550-4576. Epub 2021 Sep 14 doi: 10.1002/bit.27933. PMID: 34487351
Jin KT, Yao JY, Ying XJ, Lin Y, Chen YF
Curr Top Med Chem 2020;20(30):2737-2761. doi: 10.2174/1568026620666200922112640. PMID: 32962614
Adams SA, Nasrallah HA
Schizophr Res 2018 May;195:3-12. Epub 2017 Jul 27 doi: 10.1016/j.schres.2017.07.018. PMID: 28755877
Pang CE, Freund KB
Retina 2015 Jan;35(1):1-9. doi: 10.1097/IAE.0000000000000331. PMID: 25158945

Diagnosis

Thomas MG, Papageorgiou E, Kuht HJ, Gottlob I
Br J Ophthalmol 2022 May;106(5):593-599. Epub 2020 Nov 4 doi: 10.1136/bjophthalmol-2020-316348. PMID: 33148537
Xu A, Chen C
Int Ophthalmol 2021 Feb;41(2):727-741. Epub 2020 Oct 11 doi: 10.1007/s10792-020-01609-9. PMID: 33040254
Silas MR, Hilkert SM, Reidy JJ, Farooq AV
Br J Ophthalmol 2018 Jul;102(7):863-867. Epub 2017 Nov 9 doi: 10.1136/bjophthalmol-2017-311097. PMID: 29122822
Pichi F, Abboud EB, Ghazi NG, Khan AO
Acta Ophthalmol 2018 Aug;96(5):e549-e561. Epub 2017 Nov 2 doi: 10.1111/aos.13602. PMID: 29098804
Ilginis T, Clarke J, Patel PJ
Br Med Bull 2014 Sep;111(1):77-88. Epub 2014 Aug 18 doi: 10.1093/bmb/ldu022. PMID: 25139430

Therapy

Prince J, Kumar D, Ghosh A, Arevalo JF, Zhang AY
Curr Diab Rep 2023 Jun;23(6):119-125. Epub 2023 Apr 12 doi: 10.1007/s11892-023-01505-3. PMID: 37043090
Alves JN, Westner BU, Højlund A, Weil RS, Dalal SS
J Neurol Neurosurg Psychiatry 2023 Jun;94(6):448-456. Epub 2023 Feb 17 doi: 10.1136/jnnp-2022-329342. PMID: 36806480Free PMC Article
Komatsu H, Onoguchi G, Jerotic S, Kanahara N, Kakuto Y, Ono T, Funakoshi S, Yabana T, Nakazawa T, Tomita H
Mol Psychiatry 2022 Sep;27(9):3592-3616. Epub 2022 May 2 doi: 10.1038/s41380-022-01591-x. PMID: 35501407
Pauleikhoff D, Pauleikhoff L, Chew EY
Eye (Lond) 2022 Feb;36(2):284-293. Epub 2021 Aug 13 doi: 10.1038/s41433-021-01723-7. PMID: 34389818Free PMC Article
Greenstein VC, Lima de Carvalho JR Jr, Parmann R, Amaro-Quireza L, Lee W, Hood DC, Tsang SH, Sparrow JR
Invest Ophthalmol Vis Sci 2020 Sep 1;61(11):41. doi: 10.1167/iovs.61.11.41. PMID: 32976563Free PMC Article

Prognosis

Loewenstein A, Trivizki O
Graefes Arch Clin Exp Ophthalmol 2023 Jun;261(6):1525-1531. Epub 2022 Dec 15 doi: 10.1007/s00417-022-05931-z. PMID: 36520185Free PMC Article
Thomas MG, Papageorgiou E, Kuht HJ, Gottlob I
Br J Ophthalmol 2022 May;106(5):593-599. Epub 2020 Nov 4 doi: 10.1136/bjophthalmol-2020-316348. PMID: 33148537
Fujimoto K, Nagata T, Matsushita I, Oku K, Imagawa M, Kuniyoshi K, Hayashi T, Kimoto K, Ohji M, Kusaka S, Kondo H
Retina 2021 Mar 1;41(3):638-645. doi: 10.1097/IAE.0000000000002879. PMID: 32639332Free PMC Article
Aggarwal S, Peck T, Golen J, Karcioglu ZA
Surv Ophthalmol 2018 Sep-Oct;63(5):609-617. Epub 2018 Mar 28 doi: 10.1016/j.survophthal.2018.03.004. PMID: 29604391
Costa VP, Arcieri ES
Acta Ophthalmol Scand 2007 Sep;85(6):586-97. Epub 2007 Jun 2 doi: 10.1111/j.1600-0420.2007.00910.x. PMID: 17542978

Clinical prediction guides

Loewenstein A, Trivizki O
Graefes Arch Clin Exp Ophthalmol 2023 Jun;261(6):1525-1531. Epub 2022 Dec 15 doi: 10.1007/s00417-022-05931-z. PMID: 36520185Free PMC Article
Thomas MG, Papageorgiou E, Kuht HJ, Gottlob I
Br J Ophthalmol 2022 May;106(5):593-599. Epub 2020 Nov 4 doi: 10.1136/bjophthalmol-2020-316348. PMID: 33148537
Müller PL, Gliem M, McGuinnes M, Birtel J, Holz FG, Charbel Issa P
Am J Ophthalmol 2021 Feb;222:340-350. Epub 2020 Sep 4 doi: 10.1016/j.ajo.2020.08.042. PMID: 32891696
Fujimoto K, Nagata T, Matsushita I, Oku K, Imagawa M, Kuniyoshi K, Hayashi T, Kimoto K, Ohji M, Kusaka S, Kondo H
Retina 2021 Mar 1;41(3):638-645. doi: 10.1097/IAE.0000000000002879. PMID: 32639332Free PMC Article
Pang CE, Freund KB
Retina 2015 Jan;35(1):1-9. doi: 10.1097/IAE.0000000000000331. PMID: 25158945

Recent systematic reviews

Komatsu H, Onoguchi G, Jerotic S, Kanahara N, Kakuto Y, Ono T, Funakoshi S, Yabana T, Nakazawa T, Tomita H
Mol Psychiatry 2022 Sep;27(9):3592-3616. Epub 2022 May 2 doi: 10.1038/s41380-022-01591-x. PMID: 35501407
Xu A, Chen C
Int Ophthalmol 2021 Feb;41(2):727-741. Epub 2020 Oct 11 doi: 10.1007/s10792-020-01609-9. PMID: 33040254
Akkaya S
Int Ophthalmol 2018 Oct;38(5):2239-2246. Epub 2017 Aug 1 doi: 10.1007/s10792-017-0666-4. PMID: 28766279
Zhang Z, Yu M, Wang F, Dai Y, Wu Z
J Glaucoma 2016 May;25(5):e446-54. doi: 10.1097/IJG.0000000000000275. PMID: 25943737
Stefan C, Iliescu DA, Batras M, Timaru CM, De Simone A
Rom J Ophthalmol 2015 Jan-Mar;59(1):14-8. PMID: 27373109Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...