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Abnormal pyramidal tract morphology

MedGen UID:: 892809
•Concept ID:: C4021761
•: Anatomical Abnormality

Synonyms:	Abnormality of the pyramidal tracts; Morphological abnormality of the pyramidal tract; Pyramidal tract disease

HPO:	HP:0002062

Definition

Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal pyramidal tract morphology

Abnormality of prenatal development or birth
- Fetal anomaly
  - Congenital Systemic Disorder
    - Abnormality of the nervous system
      - Abnormal nervous system morphology
        Morphological central nervous system abnormality
        Abnormal pyramidal tract morphology
        Abnormal corticospinal tract morphology
        Corticospinal tract pallor

Professional guidelines

PubMed

Susac Syndrome: A differential diagnosis of white matter lesions.

Marrodan M, Correale J, Alessandro L, Amaya M, Fracaro ME, Köhler AA, Fiol M
Mult Scler Relat Disord 2017 Jul;15:42-46. Epub 2017 May 3 doi: 10.1016/j.msard.2017.04.007. PMID: 28641772

Brainstem corticospinal tract diffusion tensor imaging in patients with primary posterior fossa neoplasms stratified by tumor type: a study of association with motor weakness and outcome.

Lui YW, Law M, Chacko-Mathew J, Babb JS, Tuvia K, Allen JC, Zagzag D, Johnson G
Neurosurgery 2007 Dec;61(6):1199-207; discussion 1207-8. doi: 10.1227/01.neu.0000306098.38141.81. PMID: 18162899

Surgical treatment of symptomatic cavernous malformations of the brainstem.

Sola RG, Pulido P, Pastor J, Ochoa M, Castedo J
Acta Neurochir (Wien) 2007;149(5):463-70. Epub 2007 Apr 5 doi: 10.1007/s00701-007-1113-5. PMID: 17406781

See all (8)

Recent clinical studies

Etiology

Rezende TJR, Schmitt GS, de Lima FD, de Brito MR, Matos PCAAP, Bonadia LC, Martinez ARM, Cendes F, Pedroso JL, Barsottini OGP, Marques W Jr, França MC Jr
Mov Disord 2022 Oct;37(10):2122-2128. Epub 2022 Jul 25 doi: 10.1002/mds.29169. PMID: 35877029

Neurological manifestations of Erdheim-Chester Disease.

Boyd LC, O'Brien KJ, Ozkaya N, Lehky T, Meoded A, Gochuico BR, Hannah-Shmouni F, Nath A, Toro C, Gahl WA, Estrada-Veras JI, Dave RH
Ann Clin Transl Neurol 2020 Apr;7(4):497-506. Epub 2020 Mar 29 doi: 10.1002/acn3.51014. PMID: 32227455 Free PMC Article

Assessing Corticospinal Tract Asymmetry in Unilateral Polymicrogyria.

Foesleitner O, Nenning KH, Traub-Weidinger T, Feucht M, Bonelli S, Czech T, Dorfer C, Prayer D, Kasprian G
AJNR Am J Neuroradiol 2018 Aug;39(8):1530-1535. Epub 2018 Jun 28 doi: 10.3174/ajnr.A5715. PMID: 29954815 Free PMC Article

Hereditary spastic paraplegia: clinical-genetic characteristics and evolving molecular mechanisms.

Lo Giudice T, Lombardi F, Santorelli FM, Kawarai T, Orlacchio A
Exp Neurol 2014 Nov;261:518-39. Epub 2014 Jun 20 doi: 10.1016/j.expneurol.2014.06.011. PMID: 24954637

Spinocerebellar ataxia type 7.

Martin JJ
Handb Clin Neurol 2012;103:475-91. doi: 10.1016/B978-0-444-51892-7.00030-9. PMID: 21827908

See all (184)

Diagnosis

Hereditary spastic paraplegias proteome: common pathways and pathogenetic mechanisms.

Martinello C, Panza E, Orlacchio A
Expert Rev Proteomics 2023 Jul-Dec;20(7-9):171-188. Epub 2023 Oct 16 doi: 10.1080/14789450.2023.2260952. PMID: 37788157

Neurological manifestations of Erdheim-Chester Disease.

POLR3A variants with striatal involvement and extrapyramidal movement disorder.

Harting I, Al-Saady M, Krägeloh-Mann I, Bley A, Hempel M, Bierhals T, Karch S, Moog U, Bernard G, Huntsman R, van Spaendonk RML, Vreeburg M, Rodríguez-Palmero A, Pujol A, van der Knaap MS, Pouwels PJW, Wolf NI
Neurogenetics 2020 Apr;21(2):121-133. Epub 2020 Jan 15 doi: 10.1007/s10048-019-00602-4. PMID: 31940116 Free PMC Article

White matter anatomy: what the radiologist needs to know.

Wycoco V, Shroff M, Sudhakar S, Lee W
Neuroimaging Clin N Am 2013 May;23(2):197-216. Epub 2013 Jan 20 doi: 10.1016/j.nic.2012.12.002. PMID: 23608685

Spinocerebellar ataxia type 7.

Martin JJ
Handb Clin Neurol 2012;103:475-91. doi: 10.1016/B978-0-444-51892-7.00030-9. PMID: 21827908

See all (244)

Therapy

Corticospinal tract atrophy and motor fMRI predict motor preservation after functional cerebral hemispherectomy.

Wang AC, Ibrahim GM, Poliakov AV, Wang PI, Fallah A, Mathern GW, Buckley RT, Collins K, Weil AG, Shurtleff HA, Warner MH, Perez FA, Shaw DW, Wright JN, Saneto RP, Novotny EJ, Lee A, Browd SR, Ojemann JG
J Neurosurg Pediatr 2018 Jan;21(1):81-89. Epub 2017 Nov 3 doi: 10.3171/2017.7.PEDS17137. PMID: 29099351

Early Antiretroviral Therapy in HIV-Infected Children Is Associated with Diffuse White Matter Structural Abnormality and Corpus Callosum Sparing.

Ackermann C, Andronikou S, Saleh MG, Laughton B, Alhamud AA, van der Kouwe A, Kidd M, Cotton MF, Meintjes EM
AJNR Am J Neuroradiol 2016 Dec;37(12):2363-2369. Epub 2016 Aug 18 doi: 10.3174/ajnr.A4921. PMID: 27538904 Free PMC Article

Quantitative neuroimaging in mucolipidosis type IV.

Schiffmann R, Mayfield J, Swift C, Nestrasil I
Mol Genet Metab 2014 Feb;111(2):147-51. Epub 2013 Nov 21 doi: 10.1016/j.ymgme.2013.11.007. PMID: 24332805 Free PMC Article

Grey and white matter abnormalities in minimal hepatic encephalopathy: a study combining voxel-based morphometry and tract-based spatial statistics.

Qi R, Zhang LJ, Zhong J, Zhu T, Zhang Z, Xu C, Zheng G, Lu GM
Eur Radiol 2013 Dec;23(12):3370-8. Epub 2013 Jul 10 doi: 10.1007/s00330-013-2963-2. PMID: 23839169

Lasting effects of repeated rTMS application in focal hand dystonia.

Borich M, Arora S, Kimberley TJ
Restor Neurol Neurosci 2009;27(1):55-65. doi: 10.3233/RNN-2009-0461. PMID: 19164853 Free PMC Article

See all (38)

Prognosis

Prolonged central motor conduction time and pyramidal tract degeneration in amyotrophic lateral sclerosis.

Takeda T, Iijima M, Seki M, Higuchi E, Shimizu Y, Shibata N, Kitagawa K
Clin Neuropathol 2022 Jul-Aug;41(4):157-161. doi: 10.5414/NP301438. PMID: 35343426

Geometric microstructural damage of white matter with functional compensation in post-stroke.

Zhao H, Cheng J, Jiang J, Zuo L, Zhu W, Wen W, Sachdev P, Wang Y, Liu T, Li Z
Neuropsychologia 2021 Sep 17;160:107980. Epub 2021 Aug 2 doi: 10.1016/j.neuropsychologia.2021.107980. PMID: 34352268

White matter integrity in schizophrenia and bipolar disorder: Tract- and voxel-based analyses of diffusion data from the Connectom scanner.

Mamah D, Ji A, Rutlin J, Shimony JS
Neuroimage Clin 2019;21:101649. Epub 2018 Dec 31 doi: 10.1016/j.nicl.2018.101649. PMID: 30639179 Free PMC Article

Assessing Corticospinal Tract Asymmetry in Unilateral Polymicrogyria.

Senile dementia.

Terry RD
Fed Proc 1978 Dec;37(14):2837-40. PMID: 720637

See all (112)

Clinical prediction guides

Hereditary spastic paraplegias proteome: common pathways and pathogenetic mechanisms.

Martinello C, Panza E, Orlacchio A
Expert Rev Proteomics 2023 Jul-Dec;20(7-9):171-188. Epub 2023 Oct 16 doi: 10.1080/14789450.2023.2260952. PMID: 37788157

Prolonged central motor conduction time and pyramidal tract degeneration in amyotrophic lateral sclerosis.

Takeda T, Iijima M, Seki M, Higuchi E, Shimizu Y, Shibata N, Kitagawa K
Clin Neuropathol 2022 Jul-Aug;41(4):157-161. doi: 10.5414/NP301438. PMID: 35343426

Clinical and neuroimaging findings in patients with lissencephaly/subcortical band heterotopia spectrum: a magnetic resonance conventional and diffusion tensor study.

Chiba E, Kimura Y, Shimizu-Motohashi Y, Miyagawa N, Ota M, Shigemoto Y, Ohnishi M, Nakaya M, Nakagawa E, Sasaki M, Sato N
Neuroradiology 2022 Apr;64(4):825-836. Epub 2021 Oct 25 doi: 10.1007/s00234-021-02836-2. PMID: 34693484

Assessing Corticospinal Tract Asymmetry in Unilateral Polymicrogyria.

Genetic and clinical characteristics of NEFL-related Charcot-Marie-Tooth disease.

Horga A, Laurà M, Jaunmuktane Z, Jerath NU, Gonzalez MA, Polke JM, Poh R, Blake JC, Liu YT, Wiethoff S, Bettencourt C, Lunn MP, Manji H, Hanna MG, Houlden H, Brandner S, Züchner S, Shy M, Reilly MM
J Neurol Neurosurg Psychiatry 2017 Jul;88(7):575-585. Epub 2017 May 13 doi: 10.1136/jnnp-2016-315077. PMID: 28501821 Free PMC Article

See all (192)

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Abnormal pyramidal tract morphology

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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