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Abnormality of the submandibular region

MedGen UID:
892856
•Concept ID:
C4073192
•
Anatomical Abnormality
HPO: HP:0410013

Definition

Any abnormality of the submandibular region, the region between the mandible and the hyoid bone contains the submandibular and sublingual glands, suprahyoid muscles, submandibular ganglion, and lingual artery. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the submandibular region

Professional guidelines

PubMed

Appraisal of efficacy and safety of intralesional injection of high concentration of bleomycin A5 for treatment of huge macrocystic lymphatic malformations in cervical region.
Xu DP, Zhai QK, Cheng C, Gong H, Wang HW, Wang XK
J Craniofac Surg 2014 Sep;25(5):1707-9. doi: 10.1097/SCS.0000000000000900. PMID: 25119414
Botulinum toxin assessment, intervention and aftercare for paediatric and adult drooling: international consensus statement.
Reddihough D, Erasmus CE, Johnson H, McKellar GM, Jongerius PH; Cereral Palsy Institute
Eur J Neurol 2010 Aug;17 Suppl 2:109-21. doi: 10.1111/j.1468-1331.2010.03131.x. PMID: 20633182
The management of epiglottitis in a small paediatric intensive care unit.
Henry RL, Bingham AL, Halliday JA
J Qual Clin Pract 1994 Mar;14(1):17-21. PMID: 8199754

Recent clinical studies

Etiology

Ultrasound abnormalities of the major salivary glands in Egyptian patients with systemic sclerosis.
Hafez AE, Taha AM, Moshrif A, Aly HM, Abdel Noor R, Mortada M, Elkhouli R
Clin Rheumatol 2023 Dec;42(12):3351-3360. Epub 2023 Sep 18 doi: 10.1007/s10067-023-06763-w. PMID: 37721645Free PMC Article
Classification specific lymphatic malformations management on head and neck in children.
Jiang Y, Liu Y, Wang X, Chen Z, Shi W, Yu G
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Apr;135(4):e74-e82. Epub 2022 Sep 9 doi: 10.1016/j.oooo.2022.09.001. PMID: 36529676
Genetic landscape of common venous malformations in the head and neck.
Du Z, Liu JL, You YH, Wang LZ, He J, Zheng JW, Zhang ZY, Wang YA
J Vasc Surg Venous Lymphat Disord 2021 Jul;9(4):1007-1016.e7. Epub 2020 Nov 26 doi: 10.1016/j.jvsv.2020.11.016. PMID: 33248299
Submandibular osseous choristoma.
Johann AC, Garcia BG, Nacif TR, de Freitas JB, do Carmo MA, Mesquita RA
J Craniomaxillofac Surg 2006 Jan;34(1):57-9. Epub 2005 Dec 15 doi: 10.1016/j.jcms.2005.08.002. PMID: 16343914
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929

Diagnosis

FDG-PET/CT discriminates between patients with and without lymphomas in primary Sjögren's syndrome.
van Ginkel MS, Arends S, van der Vegt B, Nijland M, Spijkervet FKL, Vissink A, Kroese FGM, Glaudemans AWJM, Bootsma H
Rheumatology (Oxford) 2023 Oct 3;62(10):3323-3331. doi: 10.1093/rheumatology/kead071. PMID: 36759907Free PMC Article
A rare presentation of ectopic thyroid tissue in the submandibular region: a case report.
Obermueller T, von Bernstorff M, Sinn BV, Saadoun R, Gebhardt B, Hofmann VM
Pan Afr Med J 2021;39:217. Epub 2021 Jul 28 doi: 10.11604/pamj.2021.39.217.27390. PMID: 34630829Free PMC Article
Imaging the floor of the mouth and the sublingual space.
La'porte SJ, Juttla JK, Lingam RK
Radiographics 2011 Sep-Oct;31(5):1215-30. doi: 10.1148/rg.315105062. PMID: 21918039
Botulinum toxin assessment, intervention and aftercare for paediatric and adult drooling: international consensus statement.
Reddihough D, Erasmus CE, Johnson H, McKellar GM, Jongerius PH; Cereral Palsy Institute
Eur J Neurol 2010 Aug;17 Suppl 2:109-21. doi: 10.1111/j.1468-1331.2010.03131.x. PMID: 20633182
Submandibular osseous choristoma.
Johann AC, Garcia BG, Nacif TR, de Freitas JB, do Carmo MA, Mesquita RA
J Craniomaxillofac Surg 2006 Jan;34(1):57-9. Epub 2005 Dec 15 doi: 10.1016/j.jcms.2005.08.002. PMID: 16343914

Therapy

Randomized Controlled Trial Comparing Landmark and Ultrasound-Guided Glossopharyngeal Nerve in Eagle Syndrome.
Sundaram S, Punj J
Pain Med 2020 Jun 1;21(6):1208-1215. doi: 10.1093/pm/pnz370. PMID: 32167550
Multidetector computerized tomographic fistulography in the evaluation of congenital branchial cleft fistulae and sinuses.
Sun Z, Fu K, Zhang Z, Zhao Y, Ma X
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 May;113(5):688-94. Epub 2012 Apr 12 doi: 10.1016/j.oooo.2011.08.015. PMID: 22668628
Ectopic, submandibular thyroid causing hyperthyroidism.
Eli SU, Marnane C, Peter R, Winter S
J Laryngol Otol 2011 Oct;125(10):1091-3. Epub 2011 Jul 21 doi: 10.1017/S0022215111000855. PMID: 21774845
Botulinum toxin assessment, intervention and aftercare for paediatric and adult drooling: international consensus statement.
Reddihough D, Erasmus CE, Johnson H, McKellar GM, Jongerius PH; Cereral Palsy Institute
Eur J Neurol 2010 Aug;17 Suppl 2:109-21. doi: 10.1111/j.1468-1331.2010.03131.x. PMID: 20633182
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929

Prognosis

FDG-PET/CT discriminates between patients with and without lymphomas in primary Sjögren's syndrome.
van Ginkel MS, Arends S, van der Vegt B, Nijland M, Spijkervet FKL, Vissink A, Kroese FGM, Glaudemans AWJM, Bootsma H
Rheumatology (Oxford) 2023 Oct 3;62(10):3323-3331. doi: 10.1093/rheumatology/kead071. PMID: 36759907Free PMC Article
Adenomas of cervical maldescended parathyroid glands: pearls and pitfalls.
Lee JC, Mazeh H, Serpell J, Delbridge LW, Chen H, Sidhu S
ANZ J Surg 2015 Dec;85(12):957-61. Epub 2012 Dec 10 doi: 10.1111/ans.12017. PMID: 23216673
Multidetector computerized tomographic fistulography in the evaluation of congenital branchial cleft fistulae and sinuses.
Sun Z, Fu K, Zhang Z, Zhao Y, Ma X
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 May;113(5):688-94. Epub 2012 Apr 12 doi: 10.1016/j.oooo.2011.08.015. PMID: 22668628
Glial choristoma in the oral and maxillofacial region: a clinicopathologic study of 6 cases.
Sun LS, Sun ZP, Ma XC, Li TJ
Arch Pathol Lab Med 2008 Jun;132(6):984-8. doi: 10.5858/2008-132-984-GCITOA. PMID: 18517283
Submandibular osseous choristoma.
Johann AC, Garcia BG, Nacif TR, de Freitas JB, do Carmo MA, Mesquita RA
J Craniomaxillofac Surg 2006 Jan;34(1):57-9. Epub 2005 Dec 15 doi: 10.1016/j.jcms.2005.08.002. PMID: 16343914

Clinical prediction guides

Ultrasound abnormalities of the major salivary glands in Egyptian patients with systemic sclerosis.
Hafez AE, Taha AM, Moshrif A, Aly HM, Abdel Noor R, Mortada M, Elkhouli R
Clin Rheumatol 2023 Dec;42(12):3351-3360. Epub 2023 Sep 18 doi: 10.1007/s10067-023-06763-w. PMID: 37721645Free PMC Article
FDG-PET/CT discriminates between patients with and without lymphomas in primary Sjögren's syndrome.
van Ginkel MS, Arends S, van der Vegt B, Nijland M, Spijkervet FKL, Vissink A, Kroese FGM, Glaudemans AWJM, Bootsma H
Rheumatology (Oxford) 2023 Oct 3;62(10):3323-3331. doi: 10.1093/rheumatology/kead071. PMID: 36759907Free PMC Article
Phleboliths from venous malformations of the head and neck.
Eivazi B, Fasunla AJ, Güldner C, Masberg P, Werner JA, Teymoortash A
Phlebology 2013 Mar;28(2):86-92. Epub 2013 May 6 doi: 10.1258/phleb.2011.011029. PMID: 22302792
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Pediatric lymphangiomas of the head and neck.
Orvidas LJ, Kasperbauer JL
Ann Otol Rhinol Laryngol 2000 Apr;109(4):411-21. doi: 10.1177/000348940010900412. PMID: 10778897

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