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Abnormal corticospinal tract morphology

MedGen UID:: 893081
•Concept ID:: C4025704
•: Anatomical Abnormality

Synonyms:	Abnormality of the corticospinal tract; Involvement of the corticospinal pathways; Morphological abnormality of the corticospinal tract

HPO:	HP:0002492

Definition

Abnormality of the corticospinal tract, which is the chief element of the pyramidal system (the principle motor tract) and is the only direct connection between the cerebrum and the spinal cord. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal corticospinal tract morphology

Fetal anomaly
- Congenital Systemic Disorder
  - Abnormality of the nervous system
    - Abnormal nervous system morphology
      - Morphological central nervous system abnormality
        Abnormal pyramidal tract morphology
        Abnormal corticospinal tract morphology
        Corticospinal tract pallor

Professional guidelines

PubMed

Difference of injury of the corticospinal tract according to surgical or conservative treatment in patients with putaminal hemorrhage.

Lee AY, Choi BY, Kim SH, Chang CH, Jung YJ, Jang SH
Int J Neurosci 2016;126(5):429-35. Epub 2015 Jul 28 doi: 10.3109/00207454.2015.1026966. PMID: 26000805

Multiparametric MRI study of ALS stratified for the C9orf72 genotype.

Bede P, Bokde AL, Byrne S, Elamin M, McLaughlin RL, Kenna K, Fagan AJ, Pender N, Bradley DG, Hardiman O
Neurology 2013 Jul 23;81(4):361-9. Epub 2013 Jun 14 doi: 10.1212/WNL.0b013e31829c5eee. PMID: 23771489 Free PMC Article

Brainstem corticospinal tract diffusion tensor imaging in patients with primary posterior fossa neoplasms stratified by tumor type: a study of association with motor weakness and outcome.

Lui YW, Law M, Chacko-Mathew J, Babb JS, Tuvia K, Allen JC, Zagzag D, Johnson G
Neurosurgery 2007 Dec;61(6):1199-207; discussion 1207-8. doi: 10.1227/01.neu.0000306098.38141.81. PMID: 18162899

See all (8)

Recent clinical studies

Etiology

Rezende TJR, Schmitt GS, de Lima FD, de Brito MR, Matos PCAAP, Bonadia LC, Martinez ARM, Cendes F, Pedroso JL, Barsottini OGP, Marques W Jr, França MC Jr
Mov Disord 2022 Oct;37(10):2122-2128. Epub 2022 Jul 25 doi: 10.1002/mds.29169. PMID: 35877029

Assessing Corticospinal Tract Asymmetry in Unilateral Polymicrogyria.

Foesleitner O, Nenning KH, Traub-Weidinger T, Feucht M, Bonelli S, Czech T, Dorfer C, Prayer D, Kasprian G
AJNR Am J Neuroradiol 2018 Aug;39(8):1530-1535. Epub 2018 Jun 28 doi: 10.3174/ajnr.A5715. PMID: 29954815 Free PMC Article

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.

Fink JK
Acta Neuropathol 2013 Sep;126(3):307-28. Epub 2013 Jul 30 doi: 10.1007/s00401-013-1115-8. PMID: 23897027 Free PMC Article

Spinocerebellar ataxia type 7.

Martin JJ
Handb Clin Neurol 2012;103:475-91. doi: 10.1016/B978-0-444-51892-7.00030-9. PMID: 21827908

Hereditary spastic paraplegia.

Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

See all (266)

Diagnosis

Diffusion Magnetic Resonance Imaging Microstructural Abnormalities in Multiple System Atrophy: A Comprehensive Review.

Pasquini J, Firbank MJ, Ceravolo R, Silani V, Pavese N
Mov Disord 2022 Oct;37(10):1963-1984. Epub 2022 Aug 29 doi: 10.1002/mds.29195. PMID: 36036378 Free PMC Article

Diffusion restriction in the corticospinal tract and the corpus callosum of term neonates with hypoxic-ischemic encephalopathy.

Hayakawa K, Tanda K, Nishimura A, Koshino S, Kizaki Z, Ohno K
Pediatr Radiol 2022 Jun;52(7):1356-1369. Epub 2022 Mar 16 doi: 10.1007/s00247-022-05331-9. PMID: 35294621

Incomplete Cord Syndromes: Clinical and Imaging Review.

Kunam VK, Velayudhan V, Chaudhry ZA, Bobinski M, Smoker WRK, Reede DL
Radiographics 2018 Jul-Aug;38(4):1201-1222. doi: 10.1148/rg.2018170178. PMID: 29995620

HIV neuropathology.

Morgello S
Handb Clin Neurol 2018;152:3-19. doi: 10.1016/B978-0-444-63849-6.00002-5. PMID: 29604982

Hereditary spastic paraplegia.

Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

See all (287)

Therapy

Diffusion Magnetic Resonance Imaging Microstructural Abnormalities in Multiple System Atrophy: A Comprehensive Review.

Pasquini J, Firbank MJ, Ceravolo R, Silani V, Pavese N
Mov Disord 2022 Oct;37(10):1963-1984. Epub 2022 Aug 29 doi: 10.1002/mds.29195. PMID: 36036378 Free PMC Article

MRI of Transcallosal White Matter Helps to Predict Motor Impairment in Multiple Sclerosis.

Cordani C, Preziosa P, Valsasina P, Meani A, Pagani E, Morozumi T, Rocca MA, Filippi M
Radiology 2022 Mar;302(3):639-649. Epub 2021 Nov 30 doi: 10.1148/radiol.2021210922. PMID: 34846201

Natural history of neurological abnormalities in cerebrotendinous xanthomatosis.

Wong JC, Walsh K, Hayden D, Eichler FS
J Inherit Metab Dis 2018 Jul;41(4):647-656. Epub 2018 Feb 26 doi: 10.1007/s10545-018-0152-9. PMID: 29484516

Corticospinal tract atrophy and motor fMRI predict motor preservation after functional cerebral hemispherectomy.

Wang AC, Ibrahim GM, Poliakov AV, Wang PI, Fallah A, Mathern GW, Buckley RT, Collins K, Weil AG, Shurtleff HA, Warner MH, Perez FA, Shaw DW, Wright JN, Saneto RP, Novotny EJ, Lee A, Browd SR, Ojemann JG
J Neurosurg Pediatr 2018 Jan;21(1):81-89. Epub 2017 Nov 3 doi: 10.3171/2017.7.PEDS17137. PMID: 29099351

Hallervorden-Spatz syndrome and brain iron metabolism.

Swaiman KF
Arch Neurol 1991 Dec;48(12):1285-93. doi: 10.1001/archneur.1991.00530240091029. PMID: 1845035

See all (53)

Prognosis

Brainstem Biomarkers of Clinical Variant and Pathology in Progressive Supranuclear Palsy.

Grijalva RM, Pham NTT, Huang Q, Martin PR, Ali F, Clark HM, Duffy JR, Utianski RL, Botha H, Machulda MM, Weigand SD, Ahlskog JE, Dickson DW, Josephs KA, Whitwell JL
Mov Disord 2022 Apr;37(4):702-712. Epub 2021 Dec 31 doi: 10.1002/mds.28901. PMID: 34970796 Free PMC Article

White matter integrity in schizophrenia and bipolar disorder: Tract- and voxel-based analyses of diffusion data from the Connectom scanner.

Mamah D, Ji A, Rutlin J, Shimony JS
Neuroimage Clin 2019;21:101649. Epub 2018 Dec 31 doi: 10.1016/j.nicl.2018.101649. PMID: 30639179 Free PMC Article

Incomplete Cord Syndromes: Clinical and Imaging Review.

Kunam VK, Velayudhan V, Chaudhry ZA, Bobinski M, Smoker WRK, Reede DL
Radiographics 2018 Jul-Aug;38(4):1201-1222. doi: 10.1148/rg.2018170178. PMID: 29995620

Assessing Corticospinal Tract Asymmetry in Unilateral Polymicrogyria.

Hereditary spastic paraplegia.

Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

See all (154)

Clinical prediction guides

Diffusion restriction in the corticospinal tract and the corpus callosum of term neonates with hypoxic-ischemic encephalopathy.

Hayakawa K, Tanda K, Nishimura A, Koshino S, Kizaki Z, Ohno K
Pediatr Radiol 2022 Jun;52(7):1356-1369. Epub 2022 Mar 16 doi: 10.1007/s00247-022-05331-9. PMID: 35294621

Brainstem Biomarkers of Clinical Variant and Pathology in Progressive Supranuclear Palsy.

Clinical and neuroimaging findings in patients with lissencephaly/subcortical band heterotopia spectrum: a magnetic resonance conventional and diffusion tensor study.

Chiba E, Kimura Y, Shimizu-Motohashi Y, Miyagawa N, Ota M, Shigemoto Y, Ohnishi M, Nakaya M, Nakagawa E, Sasaki M, Sato N
Neuroradiology 2022 Apr;64(4):825-836. Epub 2021 Oct 25 doi: 10.1007/s00234-021-02836-2. PMID: 34693484

Assessing Corticospinal Tract Asymmetry in Unilateral Polymicrogyria.

Hereditary spastic paraplegia.

Fink JK
Neurol Clin 2002 Aug;20(3):711-26. doi: 10.1016/s0733-8619(02)00007-5. PMID: 12432827

See all (233)

Recent systematic reviews

Drawing connections between white matter and numerical and mathematical cognition: a literature review.

Matejko AA, Ansari D
Neurosci Biobehav Rev 2015 Jan;48:35-52. Epub 2014 Nov 15 doi: 10.1016/j.neubiorev.2014.11.006. PMID: 25446952

The value of novel MRI techniques in Parkinson-plus syndromes: diffusion tensor imaging and anatomical connectivity studies.

Tir M, Delmaire C, Besson P, Defebvre L
Rev Neurol (Paris) 2014 Apr;170(4):266-76. Epub 2014 Mar 20 doi: 10.1016/j.neurol.2013.10.013. PMID: 24656811

Autosomal dominant spastic paraplegias: a review of 89 families resulting from a portuguese survey.

Loureiro JL, Brandão E, Ruano L, Brandão AF, Lopes AM, Thieleke-Matos C, Miller-Fleming L, Cruz VT, Barbosa M, Silveira I, Stevanin G, Pinto-Basto J, Sequeiros J, Alonso I, Coutinho P
JAMA Neurol 2013 Apr;70(4):481-7. doi: 10.1001/jamaneurol.2013.1956. PMID: 23400676

See all (3)

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Abnormal corticospinal tract morphology

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

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Practice guidelines

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