U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hyperintensity of MRI T2 signal of the spinal cord

MedGen UID:
896507
•Concept ID:
C4280684
•
Finding
HPO: HP:0040272

Definition

A region of high intensity (brightness) observed upon magnetic resonance imaging (MRI) scans of the spinal cord. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperintensity of MRI T2 signal of the spinal cord

Conditions with this feature

Posterior column ataxia-retinitis pigmentosa syndrome
MedGen UID:
324636
•Concept ID:
C1836916
•
Disease or Syndrome
Posterior column ataxia with retinitis pigmentosa is an autosomal recessive neurologic disorder characterized by childhood-onset retinitis pigmentosa and later onset of gait ataxia due to sensory loss (summary by Ishiura et al., 2011).
See: Condition Record
Posterior column ataxia-retinitis pigmentosa syndrome

Professional guidelines

PubMed

Abnormal Spinal Cord Magnetic Resonance Signal: Approach to the Differential Diagnosis.
Morales H, Betts A
Semin Ultrasound CT MR 2016 Oct;37(5):372-83. Epub 2016 May 6 doi: 10.1053/j.sult.2016.05.003. PMID: 27616311
Differential diagnosis of T2 hyperintense spinal cord lesions: part B.
Bou-Haidar P, Peduto AJ, Karunaratne N
J Med Imaging Radiat Oncol 2009 Apr;53(2):152-9. doi: 10.1111/j.1754-9485.2009.02067.x. PMID: 19527360
Diagnosis and differential diagnosis of acute transverse myelopathy. The role of neuroradiological investigations and review of the literature.
Scotti G, Gerevini S
Neurol Sci 2001 Nov;22 Suppl 2:S69-73. doi: 10.1007/s100720100038. PMID: 11794482

Recent clinical studies

Etiology

Posterior spinal artery infarct.
Panesar H, Conry A, Finocchi V, Desai C, Bracewell RM
Pract Neurol 2023 Apr;23(2):160-163. Epub 2023 Mar 2 doi: 10.1136/pn-2021-003336. PMID: 36863868
Imaging Patterns Characterizing Mitochondrial Leukodystrophies.
Roosendaal SD, van de Brug T, Alves CAPF, Blaser S, Vanderver A, Wolf NI, van der Knaap MS
AJNR Am J Neuroradiol 2021 Jul;42(7):1334-1340. Epub 2021 Apr 1 doi: 10.3174/ajnr.A7097. PMID: 34255734Free PMC Article
Spinal cord involvement in adult-onset metabolic and genetic diseases.
Marelli C, Salsano E, Politi LS, Labauge P
J Neurol Neurosurg Psychiatry 2019 Feb;90(2):211-218. Epub 2018 Aug 27 doi: 10.1136/jnnp-2018-318666. PMID: 30150321
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Recurrent myelitis.
Pandit L, Rao S
J Neurol Neurosurg Psychiatry 1996 Mar;60(3):336-8. doi: 10.1136/jnnp.60.3.336. PMID: 8609515Free PMC Article

Diagnosis

Neuroimaging of Spinal Cord and Cauda Equina Disorders.
Diehn FE, Krecke KN
Continuum (Minneap Minn) 2021 Feb 1;27(1):225-263. doi: 10.1212/CON.0000000000000926. PMID: 33522744
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Differential diagnosis of T2 hyperintense spinal cord lesions: part B.
Bou-Haidar P, Peduto AJ, Karunaratne N
J Med Imaging Radiat Oncol 2009 Apr;53(2):152-9. doi: 10.1111/j.1754-9485.2009.02067.x. PMID: 19527360

Therapy

Automated signal intensity analysis of the spinal cord for detection of degenerative cervical myelopathy - a matched-pair MRI study.
Hohenhaus M, Klingler JH, Scholz C, Volz F, Hubbe U, Beck J, Reisert M, Würtemberger U, Kremers N, Wolf K
Neuroradiology 2023 Oct;65(10):1545-1554. Epub 2023 Jun 30 doi: 10.1007/s00234-023-03187-w. PMID: 37386202Free PMC Article
Posterior spinal artery infarct.
Panesar H, Conry A, Finocchi V, Desai C, Bracewell RM
Pract Neurol 2023 Apr;23(2):160-163. Epub 2023 Mar 2 doi: 10.1136/pn-2021-003336. PMID: 36863868
Case Report: Post-Chikungunya-Associated Myeloneuropathy.
Patwardhan A, Nalini A, Baishya PP, Kulanthaivelu K, Krishnareddy H, Dutta D, Chawla T, Chowdary RM, Yadav R, Vengalil S
Am J Trop Med Hyg 2021 Aug 23;105(4):942-945. doi: 10.4269/ajtmh.20-1277. PMID: 34614478Free PMC Article
A rare case of spinal epidural sarcoidosis: case report and review of the literature.
Paglia F, D'Angelo L, Armocida D, Sampirisi L, Giangaspero F, De Vincentiis L, Santoro A
Acta Neurol Belg 2021 Apr;121(2):415-420. Epub 2019 Jul 11 doi: 10.1007/s13760-019-01189-1. PMID: 31297669
Recurrent myelitis.
Pandit L, Rao S
J Neurol Neurosurg Psychiatry 1996 Mar;60(3):336-8. doi: 10.1136/jnnp.60.3.336. PMID: 8609515Free PMC Article

Prognosis

Posterior spinal artery infarct.
Panesar H, Conry A, Finocchi V, Desai C, Bracewell RM
Pract Neurol 2023 Apr;23(2):160-163. Epub 2023 Mar 2 doi: 10.1136/pn-2021-003336. PMID: 36863868
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders.
Shahriari M, Sotirchos ES, Newsome SD, Yousem DM
AJR Am J Roentgenol 2021 Apr;216(4):1031-1039. Epub 2021 Feb 17 doi: 10.2214/AJR.20.24061. PMID: 32755221
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Does the type of T2-weighted hyperintensity influence surgical outcome in patients with cervical spondylotic myelopathy? A review.
Vedantam A, Rajshekhar V
Eur Spine J 2013 Jan;22(1):96-106. Epub 2012 Aug 25 doi: 10.1007/s00586-012-2483-9. PMID: 22926434Free PMC Article
Recurrent myelitis.
Pandit L, Rao S
J Neurol Neurosurg Psychiatry 1996 Mar;60(3):336-8. doi: 10.1136/jnnp.60.3.336. PMID: 8609515Free PMC Article

Clinical prediction guides

Genotypic and phenotypic characteristics of juvenile/adult onset vanishing white matter: a series of 14 Chinese patients.
Ren Y, Yu X, Chen B, Tang H, Niu S, Wang X, Pan H, Zhang Z
Neurol Sci 2022 Aug;43(8):4961-4977. Epub 2022 Apr 7 doi: 10.1007/s10072-022-06011-0. PMID: 35389136
Solitary Fibrous Tumor/Hemangiopericytoma of Spinal Cord: A Retrospective Single-Center Study of 16 Cases.
Wang J, Zhao K, Han L, Jiao L, Liu W, Xu Y, Niu H, Ke C, Shu K, Lei T
World Neurosurg 2019 Mar;123:e629-e638. Epub 2018 Dec 13 doi: 10.1016/j.wneu.2018.12.004. PMID: 30554000
Neuroimaging Applications in Chronic Ataxias.
Mascalchi M, Vella A
Int Rev Neurobiol 2018;143:109-162. Epub 2018 Oct 29 doi: 10.1016/bs.irn.2018.09.011. PMID: 30473193
Spinal Cord Infarction: Clinical and Radiological Features.
Yadav N, Pendharkar H, Kulkarni GB
J Stroke Cerebrovasc Dis 2018 Oct;27(10):2810-2821. Epub 2018 Aug 6 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.008. PMID: 30093205
Does the type of T2-weighted hyperintensity influence surgical outcome in patients with cervical spondylotic myelopathy? A review.
Vedantam A, Rajshekhar V
Eur Spine J 2013 Jan;22(1):96-106. Epub 2012 Aug 25 doi: 10.1007/s00586-012-2483-9. PMID: 22926434Free PMC Article

Recent systematic reviews

Surgical Decompression for Cervical Spondylotic Myelopathy in Patients with Associated Hypertension: A Single-Center Retrospective Cohort and Systematic Review of the Literature.
Perdomo-Pantoja A, Chara A, Liu A, Jin Y, Taylor M, El Demerdash N, Ahmed AK, Pennington Z, Cottrill E, Westbroek EM, Bydon A, Theodore N, Witham TF
World Neurosurg 2021 Nov;155:e119-e130. Epub 2021 Aug 13 doi: 10.1016/j.wneu.2021.08.038. PMID: 34400323
Frequency, timing, and predictors of neurological dysfunction in the nonmyelopathic patient with cervical spinal cord compression, canal stenosis, and/or ossification of the posterior longitudinal ligament.
Wilson JR, Barry S, Fischer DJ, Skelly AC, Arnold PM, Riew KD, Shaffrey CI, Traynelis VC, Fehlings MG
Spine (Phila Pa 1976) 2013 Oct 15;38(22 Suppl 1):S37-54. doi: 10.1097/BRS.0b013e3182a7f2e7. PMID: 23963005

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...