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Atypical hyperplasia

MedGen UID:: 90732
•Concept ID:: C0333977
•: Pathologic Function

Synonym:	Atypical Hyperplasia
SNOMED CT:	Atypical hyperplasia (32416003)

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAtypical hyperplasia

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Non-Neoplastic Disorder
      - Non-Neoplastic Disorder by Special Category
        Hyperplasia
        Atypical hyperplasia
        Atypical Adenomatous Lung Hyperplasia
        Atypical glandular hyperplasia
        Prostatic Atypical Adenomatous Hyperplasia
        Atypical hyperplasia of breast
        Atypical lobular breast hyperplasia
        Breast Atypical Ductal Hyperplasia
        Breast Atypical Myoepitheliosis
        Breast Columnar Cell Hyperplasia with Atypia
        Atypical Mesothelial Hyperplasia
        Neoplastic C-Cell Hyperplasia

Professional guidelines

PubMed

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.

Uccella S, Zorzato PC, Dababou S, Bosco M, Torella M, Braga A, Frigerio M, Gardella B, Cianci S, Laganà AS, Franchi MP, Garzon S
Medicina (Kaunas) 2022 Sep 11;58(9) doi: 10.3390/medicina58091256. PMID: 36143933 Free PMC Article

Endometrial polyps. An evidence-based diagnosis and management guide.

Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339

Fertility-sparing management for endometrial cancer: review of the literature.

Garzon S, Uccella S, Zorzato PC, Bosco M, Franchi MP, Student V, Mariani A
Minerva Med 2021 Feb;112(1):55-69. Epub 2020 Nov 18 doi: 10.23736/S0026-4806.20.07072-X. PMID: 33205638

See all (131)

Recent clinical studies

Etiology

Endometrial Hyperplasia.

Ring KL, Mills AM, Modesitt SC
Obstet Gynecol 2022 Dec 1;140(6):1061-1075. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004989. PMID: 36357974

Benign Breast Disorders.

Weaver M, Stuckey A
Obstet Gynecol Clin North Am 2022 Mar;49(1):57-72. doi: 10.1016/j.ogc.2021.11.003. PMID: 35168773

Progesterone and endometrial cancer.

Gompel A
Best Pract Res Clin Obstet Gynaecol 2020 Nov;69:95-107. Epub 2020 Jun 9 doi: 10.1016/j.bpobgyn.2020.05.003. PMID: 32732107

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.

Doherty MT, Sanni OB, Coleman HG, Cardwell CR, McCluggage WG, Quinn D, Wylie J, McMenamin ÚC
PLoS One 2020;15(4):e0232231. Epub 2020 Apr 28 doi: 10.1371/journal.pone.0232231. PMID: 32343732 Free PMC Article

New concepts for an old problem: the diagnosis of endometrial hyperplasia.

Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066 Free PMC Article

See all (906)

Diagnosis

Endometrial Hyperplasia.

Ring KL, Mills AM, Modesitt SC
Obstet Gynecol 2022 Dec 1;140(6):1061-1075. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004989. PMID: 36357974

Benign Breast Disorders.

Weaver M, Stuckey A
Obstet Gynecol Clin North Am 2022 Mar;49(1):57-72. doi: 10.1016/j.ogc.2021.11.003. PMID: 35168773

Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.

Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.

New concepts for an old problem: the diagnosis of endometrial hyperplasia.

Sanderson PA, Critchley HO, Williams AR, Arends MJ, Saunders PT
Hum Reprod Update 2017 Mar 1;23(2):232-254. doi: 10.1093/humupd/dmw042. PMID: 27920066 Free PMC Article

See all (808)

Therapy

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.

Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.

De Rocco S, Buca D, Oronzii L, Petrillo M, Fanfani F, Nappi L, Liberati M, D'Antonio F, Scambia G, Leombroni M, Dessole M, Lucidi A
Eur J Obstet Gynecol Reprod Biol 2022 Jun;273:90-97. Epub 2022 Apr 25 doi: 10.1016/j.ejogrb.2022.04.019. PMID: 35526471

Fertility-sparing management for endometrial cancer: review of the literature.

Garzon S, Uccella S, Zorzato PC, Bosco M, Franchi MP, Student V, Mariani A
Minerva Med 2021 Feb;112(1):55-69. Epub 2020 Nov 18 doi: 10.23736/S0026-4806.20.07072-X. PMID: 33205638

Progesterone and endometrial cancer.

Gompel A
Best Pract Res Clin Obstet Gynaecol 2020 Nov;69:95-107. Epub 2020 Jun 9 doi: 10.1016/j.bpobgyn.2020.05.003. PMID: 32732107

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.

See all (322)

Prognosis

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.

Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.

Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.

Reassessing risk models for atypical hyperplasia: age may not matter.

Mazzola E, Coopey SB, Griffin M, Polubriaginof F, Buckley JM, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi A, Hughes KS
Breast Cancer Res Treat 2017 Sep;165(2):285-291. Epub 2017 Jun 6 doi: 10.1007/s10549-017-4320-7. PMID: 28589368 Free PMC Article

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.

Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N
J Natl Cancer Inst 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371. PMID: 9747868

See all (535)

Clinical prediction guides

Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma.

Hao J, Gao X, Wang YP, Liu Q, Zhu H, Zhao SJ, Qin QH, Meng J, Li LL, Lin SC, Song Z, Li H
Anticancer Drugs 2022 Jun 1;33(5):467-477. doi: 10.1097/CAD.0000000000001280. PMID: 35276691

Endometrial hyperplasia in asymptomatic subfertile population.

Aldarazi K, Omran H, Jassim NM
J Gynecol Obstet Hum Reprod 2022 Apr;51(4):102337. Epub 2022 Feb 10 doi: 10.1016/j.jogoh.2022.102337. PMID: 35151930

Effective Surveillance of High-Risk Women.

Lotz M, Ghebremichael M, Chervinsky K, Zorc T, Brenner C, Bousvaros G, Pories SE
Clin Breast Cancer 2022 Apr;22(3):e263-e269. Epub 2021 Jul 27 doi: 10.1016/j.clbc.2021.07.014. PMID: 34429241

Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.

Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D
Ultrasound Obstet Gynecol 2021 Jan;57(1):164-172. doi: 10.1002/uog.22109. PMID: 32484286

Reassessing risk models for atypical hyperplasia: age may not matter.

See all (574)

Recent systematic reviews

Efficacy, tolerability, and endometrial safety of ospemifene compared with current therapies for the treatment of vulvovaginal atrophy: a systematic literature review and network meta-analysis.

Simon JA, Ferenczy A, Black D, Castonguay A, Royer C, Marouf R, Beauchemin C
Menopause 2023 Aug 1;30(8):855-866. Epub 2023 Jun 27 doi: 10.1097/GME.0000000000002211. PMID: 37369079 Free PMC Article

Reproductive and pregnancy outcomes of fertility-sparing treatments for early-stage endometrial cancer or atypical hyperplasia: A systematic review and meta-analysis.

Concurrent and future risk of endometrial cancer in women with endometrial hyperplasia: A systematic review and meta-analysis.

Oral and intrauterine progestogens for atypical endometrial hyperplasia.

Luo L, Luo B, Zheng Y, Zhang H, Li J, Sidell N
Cochrane Database Syst Rev 2018 Dec 4;12(12):CD009458. doi: 10.1002/14651858.CD009458.pub3. PMID: 30521671 Free PMC Article

Prevalence of incidental breast cancer and precursor lesions in autopsy studies: a systematic review and meta-analysis.

Thomas ET, Del Mar C, Glasziou P, Wright G, Barratt A, Bell KJL
BMC Cancer 2017 Dec 2;17(1):808. doi: 10.1186/s12885-017-3808-1. PMID: 29197354 Free PMC Article

See all (21)

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Atypical hyperplasia

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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