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Regressing Melanoma

MedGen UID:: 90781
•Concept ID:: C0334427
•: Neoplastic Process

Synonyms:	Malignant melanoma, regressing; Regressing Malignant Melanoma
SNOMED CT:	Malignant melanoma, regressing (39896009)

Definition

A skin lesion characterized by the disappearance of the melanoma cells from the primary melanoma site. The disappearance of the malignant cells is associated with fibroplasia of the papillary dermis. According to some authors, complete regression of the primary melanoma may occur in 4-8% of patients. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRegressing Melanoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Melanoma
        Regressing Melanoma
        Regressing Cutaneous Melanoma
        Regressing Non-Cutaneous Melanoma

Professional guidelines

PubMed

Diagnosis and treatment of peripheral exudative haemorrhagic chorioretinopathy.

Vandefonteyne S, Caujolle JP, Rosier L, Conrath J, Quentel G, Tadayoni R, Maschi C, Le Mer Y, Dot C, Aknin I, Thariat J, Baillif S
Br J Ophthalmol 2020 Jun;104(6):874-878. Epub 2019 Oct 23 doi: 10.1136/bjophthalmol-2018-313307. PMID: 31645320

Glaucoma secondary to intraocular tumors: mechanisms and management.

Camp DA, Yadav P, Dalvin LA, Shields CL
Curr Opin Ophthalmol 2019 Mar;30(2):71-81. doi: 10.1097/ICU.0000000000000550. PMID: 30562240

Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.

Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414

See all (27)

Recent clinical studies

Etiology

Association between natural killer cells and regression in melanocytic lesions.

McKay K, Moore PC, Smoller BR, Hiatt KM
Hum Pathol 2011 Dec;42(12):1960-4. Epub 2011 Jun 14 doi: 10.1016/j.humpath.2011.02.019. PMID: 21676435

Eruptive multiple blue nevi of the penis: a clinical dermoscopic pathologic case study.

de Giorgi V, Massi D, Brunasso G, Salvini C, Mastrolorenzo A, Zuccati G, Carli P
J Cutan Pathol 2004 Feb;31(2):185-8. doi: 10.1111/j.0303-6987.2004.00153.x. PMID: 14690465

The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.

Prehn RT
Cancer Res 1996 Mar 1;56(5):937-940. PMID: 8640780

Pitfalls in frozen section diagnosis of malignant melanoma.

Shafir R, Hiss J, Tsur H, Bubis JJ
Cancer 1983 Mar 15;51(6):1168-70. doi: 10.1002/1097-0142(19830315)51:6<1168::aid-cncr2820510632>3.0.co;2-p. PMID: 6336989

The thin malignant melanoma: changing patterns of epidemiology and treatment.

Shafir R, Hiss J, Tsur H, Bubis JJ
Cancer 1982 Aug 15;50(4):817-9. doi: 10.1002/1097-0142(19820815)50:4<817::aid-cncr2820500434>3.0.co;2-v. PMID: 7093918

See all (6)

Diagnosis

Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma.

George EV, Kalen JE, Kapil JP, Motaparthi K
Am J Dermatopathol 2019 Jul;41(7):480-487. doi: 10.1097/DAD.0000000000001346. PMID: 30601204

Regressing seborrheic keratosis - clinically and dermoscopically mimicking a regressing melanoma.

Pastar Z, Lipozencić J, Rados J, Stajminger G
Acta Dermatovenerol Croat 2007;15(1):24-6. PMID: 17433176

Seborrheic keratoses, solar lentigines, and lichenoid keratoses. Dermatoscopic features and correlation to histology and clinical signs.

Elgart GW
Dermatol Clin 2001 Apr;19(2):347-57. doi: 10.1016/s0733-8635(05)70272-2. PMID: 11556243

Complete response of melanoma-in-transit metastasis after isolated limb perfusion with tumor necrosis factor alpha and melphalan without massive tumor necrosis: a clinical and histopathological study of the delayed-type reaction pattern.

Nooijen PT, Eggermont AM, Schalkwijk L, Henzen-Logmans S, de Waal RM, Ruiter DJ
Cancer Res 1998 Nov 1;58(21):4880-7. PMID: 9809994

Pitfalls in frozen section diagnosis of malignant melanoma.

Shafir R, Hiss J, Tsur H, Bubis JJ
Cancer 1983 Mar 15;51(6):1168-70. doi: 10.1002/1097-0142(19830315)51:6<1168::aid-cncr2820510632>3.0.co;2-p. PMID: 6336989

See all (10)

Therapy

Melanocytic and pseudomelanocytic nests coexist in interface dermatitis from head-neck sun-exposed skin: A report of three cases.

Ferrara G, Bradamante M, Broglia I, Petrillo G, Stefanato CM
J Cutan Pathol 2020 Jul;47(7):649-653. Epub 2020 Mar 20 doi: 10.1111/cup.13672. PMID: 32109330

PD-1 Blockade Expands Intratumoral Memory T Cells.

Ribas A, Shin DS, Zaretsky J, Frederiksen J, Cornish A, Avramis E, Seja E, Kivork C, Siebert J, Kaplan-Lefko P, Wang X, Chmielowski B, Glaspy JA, Tumeh PC, Chodon T, Pe'er D, Comin-Anduix B
Cancer Immunol Res 2016 Mar;4(3):194-203. Epub 2016 Jan 19 doi: 10.1158/2326-6066.CIR-15-0210. PMID: 26787823 Free PMC Article

Restricted T-cell receptor repertoire in melanoma metastases regressing after cytokine therapy.

Willhauck M, Scheibenbogen C, Pawlita M, Möhler T, Thiel E, Keilholz U
Cancer Res 2003 Jul 1;63(13):3483-5. PMID: 12839930

Nooijen PT, Eggermont AM, Schalkwijk L, Henzen-Logmans S, de Waal RM, Ruiter DJ
Cancer Res 1998 Nov 1;58(21):4880-7. PMID: 9809994

T-cell receptor beta variable region diversity in melanoma metastases after interleukin 2-based immunotherapy.

Willhauck M, Möhler T, Scheibenbogen C, Pawlita M, Brossart P, Schmier JW, Keilholz U
Clin Cancer Res 1996 Apr;2(4):767-72. PMID: 9816229

See all (5)

Prognosis

Comparison of the Inflammatory Infiltrates in Tumoral Melanosis, Regressing Nevi, and Regressing Melanoma.

George EV, Kalen JE, Kapil JP, Motaparthi K
Am J Dermatopathol 2019 Jul;41(7):480-487. doi: 10.1097/DAD.0000000000001346. PMID: 30601204

Sclerosing nevus with pseudomelanomatous features (nevus with regression-like fibrosis): clinical and dermoscopic features of a recently characterized histopathologic entity.

Ferrara G, Giorgio CM, Zalaudek I, Broganelli P, Pellacani G, Tomasini C, Argenziano G
Dermatology 2009;219(3):202-8. Epub 2009 Jul 8 doi: 10.1159/000228317. PMID: 19590167

The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.

Prehn RT
Cancer Res 1996 Mar 1;56(5):937-940. PMID: 8640780

The thin malignant melanoma: changing patterns of epidemiology and treatment.

Shafir R, Hiss J, Tsur H, Bubis JJ
Cancer 1982 Aug 15;50(4):817-9. doi: 10.1002/1097-0142(19820815)50:4<817::aid-cncr2820500434>3.0.co;2-v. PMID: 7093918

See all (4)