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Ovarian epithelial tumor

MedGen UID:
90969
•Concept ID:
C0341823
•
Neoplastic Process
Synonyms: Epithelial Neoplasm of Ovary; epithelial neoplasm of ovary; Epithelial Neoplasm of the Ovary; epithelial neoplasm of the ovary; Epithelial tumor of ovary; Epithelial Tumor of Ovary; epithelial tumor of ovary; Epithelial Tumor of the Ovary; epithelial tumor of the ovary; epithelial tumour of ovary; epithelial tumour of the ovary; Ovarian Epithelial Tumor; ovarian epithelial tumor; Ovarian Surface Epithelial-Stromal Tumor; ovarian surface epithelial-stromal tumor; ovarian surface epithelial-stromal tumour; Ovarian Surface-Epithelial Stromal Neoplasm; ovarian surface-epithelial stromal neoplasm; ovary epithelial cancer; ovary epithelial neoplasm; OVT
SNOMED CT: Epithelial tumor of ovary (237057005)
 
Monarch Initiative: MONDO:0002229

Definition

A benign, borderline, or malignant tumor that originates from the surface epithelium of the ovary. It is composed of epithelial cells and stroma. Representative examples of benign tumors include serous cystadenoma, mucinous cystadenoma, and benign Brenner tumor. Representative examples of borderline tumors include serous surface papillary tumor, mucinous adenofibroma, and borderline Brenner tumor. Representative examples of malignant tumors include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and malignant Brenner tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian epithelial tumor

Professional guidelines

PubMed

The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.
Tokunaga H, Mikami M, Nagase S, Kobayashi Y, Tabata T, Kaneuchi M, Satoh T, Hirashima Y, Matsumura N, Yokoyama Y, Kawana K, Kyo S, Aoki D, Katabuchi H
J Gynecol Oncol 2021 Mar;32(2):e49. doi: 10.3802/jgo.2021.32.e49. PMID: 33650343Free PMC Article

Recent clinical studies

Etiology

Giant Ovarian Tumor.
Kluz T, Bogaczyk A, Wita-Popów B, Habało P, Kluz-Barłowska M
Medicina (Kaunas) 2023 Oct 15;59(10) doi: 10.3390/medicina59101833. PMID: 37893550Free PMC Article
Clinical and Computed Tomographic Features of Ovarian Lesions in Infants, Children, and Adolescents: A Series of 222 Cases.
Wang Q, Yu D, Wang F
J Pediatr Adolesc Gynecol 2021 Jun;34(3):387-393. Epub 2020 Nov 1 doi: 10.1016/j.jpag.2020.10.007. PMID: 33144230
LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.
Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T
Cancer Res 2018 Jan 15;78(2):516-527. Epub 2017 Nov 29 doi: 10.1158/0008-5472.CAN-17-0910. PMID: 29187404
Expression of inflammatory cytokines in ovarian epithelial cancer and their correlation.
Tang YJ, Dou HT, Zhang QH, Liu JJ, Yang XS
J Biol Regul Homeost Agents 2017 Apr-Jun;31(2):413-418. PMID: 28685546
ELF5 in epithelial ovarian carcinoma tissues and biological behavior in ovarian carcinoma cells.
Yan H, Qiu L, Xie X, Yang H, Liu Y, Lin X, Huang H
Oncol Rep 2017 Mar;37(3):1412-1418. Epub 2017 Feb 2 doi: 10.3892/or.2017.5418. PMID: 28184931Free PMC Article

Diagnosis

Giant Ovarian Tumor.
Kluz T, Bogaczyk A, Wita-Popów B, Habało P, Kluz-Barłowska M
Medicina (Kaunas) 2023 Oct 15;59(10) doi: 10.3390/medicina59101833. PMID: 37893550Free PMC Article
MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
Clinical and Computed Tomographic Features of Ovarian Lesions in Infants, Children, and Adolescents: A Series of 222 Cases.
Wang Q, Yu D, Wang F
J Pediatr Adolesc Gynecol 2021 Jun;34(3):387-393. Epub 2020 Nov 1 doi: 10.1016/j.jpag.2020.10.007. PMID: 33144230
Protein expressions of AIB1, p53 and Bcl-2 in epithelial ovarian cancer and their correlations with the clinical pathological features and prognosis.
Liang M, Zhao J
Eur Rev Med Pharmacol Sci 2018 Aug;22(16):5134-5139. doi: 10.26355/eurrev_201808_15708. PMID: 30178833
Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-β pathways.
El-Etreby NM, Ghazy AA, Rashad R
J Ovarian Res 2017 Apr 20;10(1):28. doi: 10.1186/s13048-017-0325-4. PMID: 28427435Free PMC Article

Therapy

Activation of hedgehog signaling is not a frequent event in ovarian cancers.
Yang L, He J, Huang S, Zhang X, Bian Y, He N, Zhang H, Xie J
Mol Cancer 2009 Nov 27;8:112. doi: 10.1186/1476-4598-8-112. PMID: 19943941Free PMC Article
GnRH agonist therapy in human ovarian epithelial carcinoma (OVCAR-3) heterotransplanted in the nude mouse is characterized by latency and transience.
Peterson CM, Jolles CJ, Carrell DT, Straight RC, Jones KP, Poulson AM Jr, Hatasaka HH
Gynecol Oncol 1994 Jan;52(1):26-30. doi: 10.1006/gyno.1994.1006. PMID: 8307497
Bullatacin--in vivo and in vitro experience in an ovarian cancer model.
Holschneider CH, Johnson MT, Knox RM, Rezai A, Ryan WJ, Montz FJ
Cancer Chemother Pharmacol 1994;34(2):166-70. doi: 10.1007/BF00685935. PMID: 8194168
A newly developed in vitro chemosensitivity test (nuclear damage assay): application to ovarian cancer.
Sekiya S, Iijima N, Oosaki T, Takamizawa H, Tokita H
Gynecol Oncol 1991 Feb;40(2):138-43. doi: 10.1016/0090-8258(91)90105-e. PMID: 2010105
Cystadenocarcinoma of the ovary in a 4-year-old: benign transformation during therapy.
Hong SJ, Lurain JR, Tsukada Y, Piver MS, Humbert JR, Freeman AI
Cancer 1980 Apr 15;45(8):2227-30. doi: 10.1002/1097-0142(19800415)45:8<2227::aid-cncr2820450837>3.0.co;2-#. PMID: 7370965

Prognosis

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.
Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T
Cancer Res 2018 Jan 15;78(2):516-527. Epub 2017 Nov 29 doi: 10.1158/0008-5472.CAN-17-0910. PMID: 29187404
Expression of inflammatory cytokines in ovarian epithelial cancer and their correlation.
Tang YJ, Dou HT, Zhang QH, Liu JJ, Yang XS
J Biol Regul Homeost Agents 2017 Apr-Jun;31(2):413-418. PMID: 28685546
ELF5 in epithelial ovarian carcinoma tissues and biological behavior in ovarian carcinoma cells.
Yan H, Qiu L, Xie X, Yang H, Liu Y, Lin X, Huang H
Oncol Rep 2017 Mar;37(3):1412-1418. Epub 2017 Feb 2 doi: 10.3892/or.2017.5418. PMID: 28184931Free PMC Article
p14 expression differences in ovarian benign, borderline and malignant epithelial tumors.
Cabral VD, Cerski MR, Sa Brito IT, Kliemann LM
J Ovarian Res 2016 Oct 22;9(1):69. doi: 10.1186/s13048-016-0275-2. PMID: 27770808Free PMC Article

Clinical prediction guides

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake.
Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T
Cancer Res 2018 Jan 15;78(2):516-527. Epub 2017 Nov 29 doi: 10.1158/0008-5472.CAN-17-0910. PMID: 29187404
Expression of inflammatory cytokines in ovarian epithelial cancer and their correlation.
Tang YJ, Dou HT, Zhang QH, Liu JJ, Yang XS
J Biol Regul Homeost Agents 2017 Apr-Jun;31(2):413-418. PMID: 28685546
Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-β pathways.
El-Etreby NM, Ghazy AA, Rashad R
J Ovarian Res 2017 Apr 20;10(1):28. doi: 10.1186/s13048-017-0325-4. PMID: 28427435Free PMC Article
p14 expression differences in ovarian benign, borderline and malignant epithelial tumors.
Cabral VD, Cerski MR, Sa Brito IT, Kliemann LM
J Ovarian Res 2016 Oct 22;9(1):69. doi: 10.1186/s13048-016-0275-2. PMID: 27770808Free PMC Article

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