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Corneal keratic precipitates

MedGen UID:
910556
•Concept ID:
C2109272
•
Finding
HPO: HP:0025341

Definition

An inflammatory cellular deposit deposited on the corneal endothelium and visible as spots on the cornea. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorneal keratic precipitates

Professional guidelines

PubMed

Treatment of Cytomegalovirus Anterior Uveitis at a North American Tertiary Center With Oral Valganciclovir.
Bhoopat T, Takhar JS, Oldenburg CE, Keenan JD, Gonzales JA, Margolis TP
Cornea 2020 May;39(5):584-589. doi: 10.1097/ICO.0000000000002251. PMID: 32068609
Topical antibiotics for the management of bacterial keratitis: an evidence-based review of high quality randomised controlled trials.
McDonald EM, Ram FS, Patel DV, McGhee CN
Br J Ophthalmol 2014 Nov;98(11):1470-7. Epub 2014 Apr 12 doi: 10.1136/bjophthalmol-2013-304660. PMID: 24729078
Diagnosis, clinical features and treatment outcome of microsporidial keratoconjunctivitis.
Das S, Sharma S, Sahu SK, Nayak SS, Kar S
Br J Ophthalmol 2012 Jun;96(6):793-5. Epub 2012 Mar 21 doi: 10.1136/bjophthalmol-2011-301227. PMID: 22437900

Recent clinical studies

Etiology

Automated quantification of uveitic keratic precipitates by use of anterior segment optical coherence tomography.
Pichi F, Ometto G, Invernizzi A, Hay S, Chaudhry H, Aljneibi S, Montesano G, Zicarelli F, Neri P
Clin Exp Ophthalmol 2023 Nov;51(8):790-798. Epub 2023 Sep 17 doi: 10.1111/ceo.14296. PMID: 37717946
Floral Pattern of Keratic Precipitates in Vitreoretinal Lymphoma on In Vivo Confocal Microscopy.
Mahendradas P, Srinivasan T, Kawali A, Venkatesh R, Hazarika D, Patil S, Sanjay S, Shetty R
Ocul Immunol Inflamm 2021 Apr 3;29(3):500-506. Epub 2020 Sep 29 doi: 10.1080/09273948.2020.1821895. PMID: 32990493
Cytomegalovirus-positive corneal stromal edema with keratic precipitates after penetrating keratoplasty: a case-control study.
Chee SP, Jap A, Ling EC, Ti SE
Cornea 2013 Aug;32(8):1094-8. doi: 10.1097/ICO.0b013e318283c887. PMID: 23538617
Evaluation of keratic precipitates and corneal endothelium in Fuchs' heterochromic cyclitis by in vivo confocal microscopy.
Labbé A, Dupas B, Offret H, Baudouin C, Labetoulle M
Br J Ophthalmol 2009 May;93(5):673-7. Epub 2008 Dec 17 doi: 10.1136/bjo.2008.146100. PMID: 19091849
Evaluation of corneal endothelium and keratic precipitates by specular microscopy in anterior uveitis.
Pillai CT, Dua HS, Azuara-Blanco A, Sarhan AR
Br J Ophthalmol 2000 Dec;84(12):1367-71. doi: 10.1136/bjo.84.12.1367. PMID: 11090474Free PMC Article

Diagnosis

Monkeypox-Associated Disciform Keratitis.
Alsarhani WK, Chan CC, Boyd SR, Hasso M, Almeer A, Tan DHS
Cornea 2023 May 1;42(5):641-644. Epub 2022 Dec 9 doi: 10.1097/ICO.0000000000003171. PMID: 36729600Free PMC Article
Demystifying viral anterior uveitis: A review.
Chan NS, Chee SP
Clin Exp Ophthalmol 2019 Apr;47(3):320-333. Epub 2018 Nov 13 doi: 10.1111/ceo.13417. PMID: 30345620
Clinical Features of CMV-Associated Anterior Uveitis.
Chan NS, Chee SP, Caspers L, Bodaghi B
Ocul Immunol Inflamm 2018;26(1):107-115. Epub 2017 Nov 27 doi: 10.1080/09273948.2017.1394471. PMID: 29172842
Evaluation of keratic precipitates and corneal endothelium in Fuchs' heterochromic cyclitis by in vivo confocal microscopy.
Labbé A, Dupas B, Offret H, Baudouin C, Labetoulle M
Br J Ophthalmol 2009 May;93(5):673-7. Epub 2008 Dec 17 doi: 10.1136/bjo.2008.146100. PMID: 19091849
Intermediate uveitis.
Bonfioli AA, Damico FM, Curi AL, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):147-54. doi: 10.1080/08820530500232035. PMID: 16282148

Therapy

Monkeypox-Associated Disciform Keratitis.
Alsarhani WK, Chan CC, Boyd SR, Hasso M, Almeer A, Tan DHS
Cornea 2023 May 1;42(5):641-644. Epub 2022 Dec 9 doi: 10.1097/ICO.0000000000003171. PMID: 36729600Free PMC Article
Microsporidia-Associated Anterior Uveitis After Keratoconjunctivitis.
Mohanty A, Kelgaonkar A, Behera HS, Mallick A, Das S, Rekha Priyadarshini S, Chaurasia S, Sahu SK
Cornea 2023 Nov 1;42(11):1439-1445. Epub 2023 Jan 18 doi: 10.1097/ICO.0000000000003230. PMID: 36727968
Cytomegalovirus-positive corneal stromal edema with keratic precipitates after penetrating keratoplasty: a case-control study.
Chee SP, Jap A, Ling EC, Ti SE
Cornea 2013 Aug;32(8):1094-8. doi: 10.1097/ICO.0b013e318283c887. PMID: 23538617
Linear endotheliitis.
Olsen TW, Hardten DR, Meiusi RS, Holland EJ
Am J Ophthalmol 1994 Apr 15;117(4):468-74. doi: 10.1016/s0002-9394(14)70006-6. PMID: 8154528
Presumed autoimmune corneal endotheliopathy.
Paul RH
Am J Ophthalmol 1988 May 15;105(5):519-22. doi: 10.1016/0002-9394(88)90244-9. PMID: 3285693

Prognosis

Toxic anterior segment syndrome (TASS): A review and update.
Verma L, Malik A, Maharana PK, Dada T, Sharma N
Indian J Ophthalmol 2024 Jan 1;72(1):11-18. Epub 2023 Dec 22 doi: 10.4103/IJO.IJO_1796_23. PMID: 38131565Free PMC Article
Long-Term Topical Ganciclovir and Corticosteroids Preserve Corneal Endothelial Function in Cytomegalovirus Corneal Endotheliitis.
Fan NW, Chung YC, Liu YC, Liu CJ, Kuo YS, Lin PY
Cornea 2016 May;35(5):596-601. doi: 10.1097/ICO.0000000000000791. PMID: 26967107
Microsporidia infection of the cornea--a unique and challenging disease.
Garg P
Cornea 2013 Nov;32 Suppl 1:S33-8. doi: 10.1097/ICO.0b013e3182a2c91f. PMID: 24104931
In vivo confocal microscopy of keratic precipitates in infectious versus noninfectious uveitis.
Mahendradas P, Shetty R, Narayana KM, Shetty BK
Ophthalmology 2010 Feb;117(2):373-80. doi: 10.1016/j.ophtha.2009.07.016. PMID: 20022116
Intermediate uveitis.
Bonfioli AA, Damico FM, Curi AL, Orefice F
Semin Ophthalmol 2005 Jul-Sep;20(3):147-54. doi: 10.1080/08820530500232035. PMID: 16282148

Clinical prediction guides

Preliminary clinical report of alternate episodes of Posner-Schlossman syndrome and viral keratitis.
Sun Z, Cao DM, Zhang Y, Zhou HZ
Transpl Immunol 2022 Oct;74:101673. Epub 2022 Jul 18 doi: 10.1016/j.trim.2022.101673. PMID: 35863606
In vivo confocal microscopic evaluation of keratic precipitates and endothelial morphology in Fuchs' uveitis syndrome.
Mocan MC, Kadayifcilar S, Irkeç M
Eye (Lond) 2012 Jan;26(1):119-25. Epub 2011 Nov 4 doi: 10.1038/eye.2011.268. PMID: 22056870Free PMC Article
Evaluation of keratic precipitates and corneal endothelium in Fuchs' heterochromic cyclitis by in vivo confocal microscopy.
Labbé A, Dupas B, Offret H, Baudouin C, Labetoulle M
Br J Ophthalmol 2009 May;93(5):673-7. Epub 2008 Dec 17 doi: 10.1136/bjo.2008.146100. PMID: 19091849
In vivo confocal microscopy of keratic precipitates.
Wertheim MS, Mathers WD, Planck SJ, Martin TM, Suhler EB, Smith JR, Rosenbaum JT
Arch Ophthalmol 2004 Dec;122(12):1773-81. doi: 10.1001/archopht.122.12.1773. PMID: 15596579
Evaluation of corneal endothelium and keratic precipitates by specular microscopy in anterior uveitis.
Pillai CT, Dua HS, Azuara-Blanco A, Sarhan AR
Br J Ophthalmol 2000 Dec;84(12):1367-71. doi: 10.1136/bjo.84.12.1367. PMID: 11090474Free PMC Article

Recent systematic reviews

Topical antibiotics for the management of bacterial keratitis: an evidence-based review of high quality randomised controlled trials.
McDonald EM, Ram FS, Patel DV, McGhee CN
Br J Ophthalmol 2014 Nov;98(11):1470-7. Epub 2014 Apr 12 doi: 10.1136/bjophthalmol-2013-304660. PMID: 24729078

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