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Cavernous hemangioma

MedGen UID:
9184
Concept ID:
C0018920
Neoplastic Process
Synonyms: Cavernous Hemangioma; Cavernous Hemangiomas; Hemangioma, Cavernous; Hemangioma, Strawberry; Hemangiomas, Cavernous; Hemangiomas, Strawberry; Strawberry Hemangioma; Strawberry Hemangiomas
SNOMED CT: Cavernous hemangioma (416824008); Cavernous nevus (416824008); Strawberry hemangioma (56975005); Cavernous hemangioma (33377007)
 
HPO: HP:0001048
Monarch Initiative: MONDO:0003155

Definition

The presence of a cavernous hemangioma. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma. [from HPO]

Conditions with this feature

Cardio-facio-cutaneous syndrome
MedGen UID:
266149
Concept ID:
C1275081
Disease or Syndrome
Cardiofaciocutaneous (CFC) syndrome is characterized by cardiac abnormalities (pulmonic stenosis and other valve dysplasias, septal defects, hypertrophic cardiomyopathy, rhythm disturbances), distinctive craniofacial appearance, and cutaneous abnormalities (including xerosis, hyperkeratosis, ichthyosis, keratosis pilaris, ulerythema ophryogenes, eczema, pigmented moles, hemangiomas, and palmoplantar hyperkeratosis). The hair is typically sparse, curly, fine or thick, woolly or brittle; eyelashes and eyebrows may be absent or sparse. Nails may be dystrophic or fast growing. Some form of neurologic and/or cognitive delay (ranging from mild to severe) is seen in all affected individuals. Neoplasia, mostly acute lymphoblastic leukemia, has been reported in some individuals.
Hemangiomas of small intestine
MedGen UID:
331098
Concept ID:
C1841654
Neoplastic Process
A hemangioma that involves the small intestine.
Mucolipidosis type II
MedGen UID:
435914
Concept ID:
C2673377
Disease or Syndrome
GNPTAB-related disorders comprise the phenotypes mucolipidosis II (ML II) and mucolipidosis IIIa/ß (ML IIIa/ß), and phenotypes intermediate between ML II and ML IIIa/ß. ML II is evident at birth and slowly progressive; death most often occurs in early childhood. Orthopedic abnormalities present at birth may include thoracic deformity, kyphosis, clubfeet, deformed long bones, and/or dislocation of the hip(s). Growth often ceases in the second year of life; contractures develop in all large joints. The skin is thickened, facial features are coarse, and gingiva are hypertrophic. All children have cardiac involvement, most commonly thickening and insufficiency of the mitral valve and, less frequently, the aortic valve. Progressive mucosal thickening narrows the airways, and gradual stiffening of the thoracic cage contributes to respiratory insufficiency, the most common cause of death. ML IIIa/ß becomes evident at about age three years with slow growth rate and short stature; joint stiffness and pain initially in the shoulders, hips, and fingers; gradual mild coarsening of facial features; and normal to mildly impaired cognitive development. Pain from osteoporosis becomes more severe during adolescence. Cardiorespiratory complications (restrictive lung disease, thickening and insufficiency of the mitral and aortic valves, left and/or right ventricular hypertrophy) are common causes of death, typically in early to middle adulthood. Phenotypes intermediate between ML II and ML IIIa/ß are characterized by physical growth in infancy that resembles that of ML II and neuromotor and speech development that resemble that of ML IIIa/ß.
Adams-Oliver syndrome 5
MedGen UID:
863407
Concept ID:
C4014970
Disease or Syndrome
Adams-Oliver syndrome (AOS) is characterized by aplasia cutis congenita (ACC) of the scalp and terminal transverse limb defects (TTLD). ACC lesions usually occur in the midline of the parietal or occipital regions, but can also occur on the abdomen or limbs. At birth, an ACC lesion may already have the appearance of a healed scar. ACC lesions less than 5 cm often involve only the skin and almost always heal over a period of months; larger lesions are more likely to involve the skull and possibly the dura, and are at greater risk for complications, which can include infection, hemorrhage, or thrombosis, and can result in death. The limb defects range from mild (unilateral or bilateral short distal phalanges) to severe (complete absence of all toes or fingers, feet or hands, or more, often resembling an amputation). The lower extremities are almost always more severely affected than the upper extremities. Additional major features frequently include cardiovascular malformations/dysfunction (23%), brain anomalies, and less frequently renal, liver, and eye anomalies.
Lymphatic malformation 13
MedGen UID:
1840915
Concept ID:
C5830279
Disease or Syndrome
Lymphatic malformation-13 (LMPHM13) is characterized by the presence of nonimmune hydrops fetalis which often resolves with age. Capillary or cavernous hemangiomas are present in most patients, as are cardiac defects, often mild (Abdelrahman et al., 2018). For a discussion of genetic heterogeneity of lymphatic malformation, see 153100.

Professional guidelines

PubMed

Zou X, Wang L, Xiao L, Wang S, Zhang L
Front Immunol 2022;13:975921. Epub 2022 Oct 31 doi: 10.3389/fimmu.2022.975921. PMID: 36389714Free PMC Article
Muntianu LAS, Mihai G, Bodnar T
J Craniofac Surg 2022 Jul-Aug 01;33(5):e470-e472. Epub 2022 Jun 27 doi: 10.1097/SCS.0000000000008365. PMID: 35758425
Choi BY, Nguyen MH
J Clin Gastroenterol 2005 May-Jun;39(5):401-12. doi: 10.1097/01.mcg.0000159226.63037.a2. PMID: 15815209

Recent clinical studies

Etiology

Ganz JC
Prog Brain Res 2022;268(1):115-132. Epub 2022 Jan 6 doi: 10.1016/bs.pbr.2021.10.029. PMID: 35074077
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
Wang K, Zhou HJ, Wang M
Stroke Vasc Neurol 2019 Jul;4(2):67-70. Epub 2019 Mar 2 doi: 10.1136/svn-2018-000195. PMID: 31338212Free PMC Article
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Diagnosis

Rabelo NN, Chaves PHS, Oliveira MA, Silva LUMAD, Pinto MB
Br J Neurosurg 2024 Apr;38(2):534-535. Epub 2020 Sep 22 doi: 10.1080/02688697.2020.1821868. PMID: 32959687
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Torres G, Kini AT, Al Othman B, Lee AG
J Neuroophthalmol 2020 Jun;40(2):262-264. doi: 10.1097/WNO.0000000000000778. PMID: 30893269
Zhu WD, Huang Q, Li XY, Chen HS, Wang ZY, Wu H
J Neurosurg 2016 Mar;124(3):639-46. Epub 2015 Sep 25 doi: 10.3171/2015.3.JNS142785. PMID: 26406793
Rivera PP, Willinsky RA, Porter PJ
Neuroimaging Clin N Am 2003 Feb;13(1):27-40. doi: 10.1016/s1052-5149(02)00060-6. PMID: 12802939

Therapy

Brichacek M, Naeem A, Filler G, Hammond R, Yazdani A, Ranger A
J Craniofac Surg 2018 Sep;29(6):1625-1628. doi: 10.1097/SCS.0000000000004613. PMID: 29742579
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155
Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML
Nature 2017 May 18;545(7654):305-310. Epub 2017 May 10 doi: 10.1038/nature22075. PMID: 28489816Free PMC Article
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Prognosis

Flemming KD
Methods Mol Biol 2020;2152:27-33. doi: 10.1007/978-1-0716-0640-7_2. PMID: 32524541
Bai Y, Zhao G, Tan Y
World J Surg Oncol 2019 Dec 4;17(1):205. doi: 10.1186/s12957-019-1742-1. PMID: 31801558Free PMC Article
Goldstein HE, Solomon RA
Handb Clin Neurol 2017;143:241-247. doi: 10.1016/B978-0-444-63640-9.00023-0. PMID: 28552146
Wang W, Chen L
Retina 2017 Apr;37(4):611-621. doi: 10.1097/IAE.0000000000001374. PMID: 27820777
Yamada S, Nakase H, Nakagawa I, Nishimura F, Motoyama Y, Park YS
Neurol Med Chir (Tokyo) 2013;53(8):555-60. doi: 10.2176/nmc.53.555. PMID: 23979052

Clinical prediction guides

Jaman E, Abdallah HM, Zhang X, Greene S
J Neurosurg Pediatr 2023 Oct 1;32(4):506-513. Epub 2023 Jul 21 doi: 10.3171/2023.5.PEDS22397. PMID: 37503918
Mirzayev I, Gündüz AK
Turk J Ophthalmol 2022 Dec 28;52(6):421-431. doi: 10.4274/tjo.galenos.2022.25979. PMID: 36578224Free PMC Article
Santos AN, Rauschenbach L, Saban D, Chen B, Darkwah Oppong M, Herten A, Gull HH, Rieß C, Deuschl C, Schmidt B, Jabbarli R, Wrede KH, Zhu Y, Frank B, Sure U, Dammann P
Eur J Neurol 2022 May;29(5):1427-1434. Epub 2022 Feb 3 doi: 10.1111/ene.15253. PMID: 35060255
Hong T, Xiao X, Ren J, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H, Wang Y
Brain 2021 Oct 22;144(9):2648-2658. doi: 10.1093/brain/awab117. PMID: 33729480
Bai Y, Zhao G, Tan Y
World J Surg Oncol 2019 Dec 4;17(1):205. doi: 10.1186/s12957-019-1742-1. PMID: 31801558Free PMC Article

Recent systematic reviews

Koester SW, Rhodenhiser EG, Dabrowski SJ, Benner D, Rumalla K, Scherschinski L, Catapano JS, Graffeo CS, Srinivasan VM, Lawton MT
World Neurosurg 2023 Nov;179:222-232.e2. Epub 2023 Aug 17 doi: 10.1016/j.wneu.2023.08.036. PMID: 37595838
Zou X, Wang L, Xiao L, Wang S, Zhang L
Front Immunol 2022;13:975921. Epub 2022 Oct 31 doi: 10.3389/fimmu.2022.975921. PMID: 36389714Free PMC Article
Aziz H, Brown ZJ, Baghdadi A, Kamel IR, Pawlik TM
J Gastrointest Surg 2022 Sep;26(9):1998-2007. Epub 2022 Jun 15 doi: 10.1007/s11605-022-05382-1. PMID: 35705835
Harris L, Poorthuis MHF, Grover P, Kitchen N, Al-Shahi Salman R
Neurosurg Rev 2022 Feb;45(1):231-241. Epub 2021 Jun 30 doi: 10.1007/s10143-021-01591-5. PMID: 34191202
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

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