U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Complicated malaria

MedGen UID:
923528
Concept ID:
C2747816
Disease or Syndrome
Synonyms: Severe Malaria; Severe malaria
SNOMED CT: Complicated malaria (1141602008); Severe malaria (1141602008)

Definition

Acute malaria with signs of organ dysfunction, severe anemia (hemoglobin less than 5 g/dL or hematocrit less than 15%) and/or hyperparasitemia (greater than 5% of red blood cells infected). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComplicated malaria

Professional guidelines

PubMed

Al Khaja KAJ, Sequeira RP
Malar J 2021 Jan 23;20(1):62. doi: 10.1186/s12936-020-03565-2. PMID: 33485330Free PMC Article
Lalloo DG, Shingadia D, Bell DJ, Beeching NJ, Whitty CJM, Chiodini PL; PHE Advisory Committee on Malaria Prevention in UK Travellers
J Infect 2016 Jun;72(6):635-649. Epub 2016 Feb 12 doi: 10.1016/j.jinf.2016.02.001. PMID: 26880088Free PMC Article
Mishra SK, Mohanty S, Mohanty A, Das BS
J Postgrad Med 2006 Oct-Dec;52(4):281-7. PMID: 17102547

Recent clinical studies

Etiology

Hashmi F, Aqeel S, Zuberi UF, Khan W
Cytokine 2023 Sep;169:156305. Epub 2023 Jul 21 doi: 10.1016/j.cyto.2023.156305. PMID: 37482049
Mikobi TM, Kamuanya NC, Akilimali PZ, Lukusa PT
PLoS One 2022;17(10):e0275115. Epub 2022 Oct 6 doi: 10.1371/journal.pone.0275115. PMID: 36201515Free PMC Article
Kariuki SN, Williams TN
Hum Genet 2020 Jun;139(6-7):801-811. Epub 2020 Mar 4 doi: 10.1007/s00439-020-02142-6. PMID: 32130487Free PMC Article
Basu S, Sahi PK
Indian J Pediatr 2017 Jul;84(7):521-528. Epub 2017 Mar 30 doi: 10.1007/s12098-017-2332-2. PMID: 28357581
Lalloo DG, Shingadia D, Bell DJ, Beeching NJ, Whitty CJM, Chiodini PL; PHE Advisory Committee on Malaria Prevention in UK Travellers
J Infect 2016 Jun;72(6):635-649. Epub 2016 Feb 12 doi: 10.1016/j.jinf.2016.02.001. PMID: 26880088Free PMC Article

Diagnosis

Hashmi F, Aqeel S, Zuberi UF, Khan W
Cytokine 2023 Sep;169:156305. Epub 2023 Jul 21 doi: 10.1016/j.cyto.2023.156305. PMID: 37482049
Mikobi TM, Kamuanya NC, Akilimali PZ, Lukusa PT
PLoS One 2022;17(10):e0275115. Epub 2022 Oct 6 doi: 10.1371/journal.pone.0275115. PMID: 36201515Free PMC Article
Basu S, Sahi PK
Indian J Pediatr 2017 Jul;84(7):521-528. Epub 2017 Mar 30 doi: 10.1007/s12098-017-2332-2. PMID: 28357581
Lalloo DG, Shingadia D, Bell DJ, Beeching NJ, Whitty CJM, Chiodini PL; PHE Advisory Committee on Malaria Prevention in UK Travellers
J Infect 2016 Jun;72(6):635-649. Epub 2016 Feb 12 doi: 10.1016/j.jinf.2016.02.001. PMID: 26880088Free PMC Article
Mishra SK, Mohanty S, Mohanty A, Das BS
J Postgrad Med 2006 Oct-Dec;52(4):281-7. PMID: 17102547

Therapy

Hashmi F, Aqeel S, Zuberi UF, Khan W
Cytokine 2023 Sep;169:156305. Epub 2023 Jul 21 doi: 10.1016/j.cyto.2023.156305. PMID: 37482049
Al Khaja KAJ, Sequeira RP
Malar J 2021 Jan 23;20(1):62. doi: 10.1186/s12936-020-03565-2. PMID: 33485330Free PMC Article
Basu S, Sahi PK
Indian J Pediatr 2017 Jul;84(7):521-528. Epub 2017 Mar 30 doi: 10.1007/s12098-017-2332-2. PMID: 28357581
Lalloo DG, Shingadia D, Bell DJ, Beeching NJ, Whitty CJM, Chiodini PL; PHE Advisory Committee on Malaria Prevention in UK Travellers
J Infect 2016 Jun;72(6):635-649. Epub 2016 Feb 12 doi: 10.1016/j.jinf.2016.02.001. PMID: 26880088Free PMC Article
Amador R, Patarroyo ME
J Clin Immunol 1996 Jul;16(4):183-9. doi: 10.1007/BF01541223. PMID: 8840219

Prognosis

Godara P, Naik B, Meghwal R, Ojha R, Srivastava V, Prajapati VK, Prusty D
Life Sci 2022 Dec 15;311(Pt A):121121. Epub 2022 Oct 23 doi: 10.1016/j.lfs.2022.121121. PMID: 36283456
Trivedi T, Bajaj P, Moulick N, Padwal N
J Assoc Physicians India 2018 Apr;66(4):16-20. PMID: 30347945
Arévalo-Herrera M, Rengifo L, Lopez-Perez M, Arce-Plata MI, García J, Herrera S
PLoS One 2017;12(9):e0185435. Epub 2017 Sep 25 doi: 10.1371/journal.pone.0185435. PMID: 28945797Free PMC Article
Lalloo DG, Shingadia D, Bell DJ, Beeching NJ, Whitty CJM, Chiodini PL; PHE Advisory Committee on Malaria Prevention in UK Travellers
J Infect 2016 Jun;72(6):635-649. Epub 2016 Feb 12 doi: 10.1016/j.jinf.2016.02.001. PMID: 26880088Free PMC Article
Subudhi AK, Boopathi PA, Pandey I, Kohli R, Karwa R, Middha S, Acharya J, Kochar SK, Kochar DK, Das A
Mol Biochem Parasitol 2015 May;201(1):31-46. Epub 2015 May 27 doi: 10.1016/j.molbiopara.2015.05.005. PMID: 26022315

Clinical prediction guides

Fox DJ, Karstaedt A, Menezes CN
S Afr Med J 2021 Sep 2;111(9):862-871. PMID: 34949251
Al Khaja KAJ, Sequeira RP
Malar J 2021 Jan 23;20(1):62. doi: 10.1186/s12936-020-03565-2. PMID: 33485330Free PMC Article
Van Geertruyden JP
Clin Microbiol Infect 2014 Apr;20(4):278-85. doi: 10.1111/1469-0691.12597. PMID: 24528518Free PMC Article
Biryukov S, Stoute JA
Trends Mol Med 2014 May;20(5):293-301. Epub 2014 Feb 6 doi: 10.1016/j.molmed.2014.01.001. PMID: 24508275
Ioannidis LJ, Nie CQ, Hansen DS
Parasitology 2014 Apr;141(5):602-13. Epub 2013 Dec 13 doi: 10.1017/S0031182013001984. PMID: 24476686Free PMC Article

Recent systematic reviews

Hashmi F, Aqeel S, Zuberi UF, Khan W
Cytokine 2023 Sep;169:156305. Epub 2023 Jul 21 doi: 10.1016/j.cyto.2023.156305. PMID: 37482049
Wilairatana P, Kwankaew P, Kotepui KU, Kotepui M
Int J Environ Res Public Health 2022 Jul 30;19(15) doi: 10.3390/ijerph19159345. PMID: 35954703Free PMC Article
Mahittikorn A, Mala W, Srisuphanunt M, Masangkay FR, Kotepui KU, Wilairatana P, Kotepui M
J Travel Med 2022 Jul 14;29(4) doi: 10.1093/jtm/taac053. PMID: 35467747
Mala W, Wilairatana P, Samerjai C, Masangkay FR, Kotepui KU, Kotepui M
Int J Environ Res Public Health 2022 Jan 21;19(3) doi: 10.3390/ijerph19031196. PMID: 35162229Free PMC Article
Saeheng T, Na-Bangchang K
Malar J 2022 Feb 10;21(1):41. doi: 10.1186/s12936-022-04065-1. PMID: 35144612Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...