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Vaginal Large Cell Neuroendocrine Carcinoma

MedGen UID:
925571
•Concept ID:
C4288039
•
Neoplastic Process

Definition

A rare, aggressive neuroendocrine carcinoma that arises from the vagina and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Large Cell Neuroendocrine Carcinoma

Recent clinical studies

Etiology

Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790
Large cell neuroendocrine tumor of the cervix and human papillomavirus 16: a case report.
Powell JL, McKinney CD
J Low Genit Tract Dis 2008 Jul;12(3):242-4. doi: 10.1097/LGT.0b013e3181641b4f. PMID: 18596468
Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases.
Conner MG, Richter H, Moran CA, Hameed A, Albores-Saavedra J
Ann Diagn Pathol 2002 Dec;6(6):345-8. doi: 10.1053/adpa.2002.36661. PMID: 12478483
Large cell neuroendocrine [corrected] carcinoma of the uterine cervix: a clinicopathologic study of 12 cases.
Gilks CB, Young RH, Gersell DJ, Clement PB
Am J Surg Pathol 1997 Aug;21(8):905-14. doi: 10.1097/00000478-199708000-00004. PMID: 9255253

Diagnosis

Small-cell neuroendocrine carcinoma of the cervix accompanied by adenocarcinoma and high-grade squamous intraepithelial lesion.
Okabe A, Ishida M, Noda Y, Okano K, Sandoh K, Fukuda H, Kita M, Okada H, Tsuta K
Diagn Cytopathol 2022 Oct;50(10):E285-E288. Epub 2022 Jun 2 doi: 10.1002/dc.24997. PMID: 35652304
Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract.
Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vlădăreanu EM, Berceanu C, Ducu I, Iordache AM
Medicina (Kaunas) 2021 Dec 7;57(12) doi: 10.3390/medicina57121338. PMID: 34946283Free PMC Article
Large cell neuroendocrine carcinoma of the uterine cervix.
Habeeb A, Habeeb H
BMJ Case Rep 2019 Jan 14;12(1) doi: 10.1136/bcr-2018-225880. PMID: 30642849Free PMC Article
Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Neuroendocrine tumors of the gynecologic tract: select topics.
Rouzbahman M, Clarke B
Semin Diagn Pathol 2013 Aug;30(3):224-33. doi: 10.1053/j.semdp.2013.06.007. PMID: 24144291

Therapy

Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma: A case report and literature review.
Hu R, Jiang J, Song G, Zhu C, Chen L, Wang C, Wang X
Medicine (Baltimore) 2019 Jul;98(29):e16433. doi: 10.1097/MD.0000000000016433. PMID: 31335697Free PMC Article
Atypical carcinoid of the uterine cervix accompanying adenocarcinoma in situ.
Ling C, Shen Y
J Clin Pathol 2018 Nov;71(11):1030. Epub 2018 Aug 28 doi: 10.1136/jclinpath-2018-205081. PMID: 30154130
Large-cell neuroendocrine carcinoma of the uterine cervix complicating pregnancy.
Li WW, Yau TN, Leung CW, Pong WM, Chan MY
Hong Kong Med J 2009 Feb;15(1):69-72. PMID: 19197101

Prognosis

Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract.
Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vlădăreanu EM, Berceanu C, Ducu I, Iordache AM
Medicina (Kaunas) 2021 Dec 7;57(12) doi: 10.3390/medicina57121338. PMID: 34946283Free PMC Article
Large cell neuroendocrine carcinoma of the uterine cervix.
Habeeb A, Habeeb H
BMJ Case Rep 2019 Jan 14;12(1) doi: 10.1136/bcr-2018-225880. PMID: 30642849Free PMC Article
Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790
Neuroendocrine tumors of the genital tract.
Eichhorn JH, Young RH
Am J Clin Pathol 2001 Jun;115 Suppl:S94-112. doi: 10.1309/64CW-WKGK-49EF-BYD1. PMID: 11993694

Clinical prediction guides

Atypical carcinoid of the uterine cervix accompanying adenocarcinoma in situ.
Ling C, Shen Y
J Clin Pathol 2018 Nov;71(11):1030. Epub 2018 Aug 28 doi: 10.1136/jclinpath-2018-205081. PMID: 30154130
Adenocarcinoma in situ admixed with small cell neuroendocrine carcinoma of the cervix: A case report with cytological features.
Nishiumi Y, Nishimura T, Kashu I, Aoki T, Itoh R, Tsuta K, Ishida M
Diagn Cytopathol 2018 Sep;46(9):752-755. Epub 2018 Apr 15 doi: 10.1002/dc.23940. PMID: 29656585
Neuroendocrine Carcinoma of the Endometrium: A Clinicopathologic Study of 25 Cases.
Pocrnich CE, Ramalingam P, Euscher ED, Malpica A
Am J Surg Pathol 2016 May;40(5):577-86. doi: 10.1097/PAS.0000000000000633. PMID: 26945341Free PMC Article
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790
Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis.
Albores-Saavedra J, Martinez-Benitez B, Luevano E
Int J Gynecol Pathol 2008 Jul;27(3):333-9. doi: 10.1097/PGP.0b013e31815de006. PMID: 18580310

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