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Mixed Failure to Thrive

MedGen UID:: 926262
•Concept ID:: C4288730
•: Finding

Synonym:

Mixed FTT

Definition

Failure to thrive due to both organic and non-organic causes. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMixed Failure to Thrive

Phenotypic abnormality
- Growth abnormality
  - Abnormality of body weight
    - Decreased body weight
      - Failure to thrive
        Mixed Failure to Thrive

Professional guidelines

PubMed

Functional treatment of airway obstruction and feeding problems in infants with Robin sequence.

Buchenau W, Wenzel S, Bacher M, Müller-Hagedorn S, Arand J, Poets CF
Arch Dis Child Fetal Neonatal Ed 2017 Mar;102(2):F142-F146. Epub 2016 Jul 19 doi: 10.1136/archdischild-2016-311407. PMID: 27435577

Newborn screening for cystic fibrosis: evaluation of benefits and risks and recommendations for state newborn screening programs.

Grosse SD, Boyle CA, Botkin JR, Comeau AM, Kharrazi M, Rosenfeld M, Wilfond BS; CDC
MMWR Recomm Rep 2004 Oct 15;53(RR-13):1-36. PMID: 15483524

Management of children with failure to thrive in a rural ambulatory setting. Epidemiology and growth outcomes.

Casey PH, Wortham B, Nelson JY
Clin Pediatr (Phila) 1984 Jun;23(6):325-30. doi: 10.1177/000992288402300604. PMID: 6723176

See all (3)

Recent clinical studies

Etiology

Etiologies of Poor Weight Gain and Ultimate Diagnosis in Children Admitted for Growth Faltering.

Peterson Lu E, Bowen J, Foglia M, Ribar E, Mack M, Sondhi E, Hickey RW
Hosp Pediatr 2023 May 1;13(5):394-402. doi: 10.1542/hpeds.2022-007038. PMID: 37082920

Feeding Interventions for Infants with Growth Failure in the First Six Months of Life: A Systematic Review.

Rana R, McGrath M, Gupta P, Thakur E, Kerac M
Nutrients 2020 Jul 9;12(7) doi: 10.3390/nu12072044. PMID: 32660020 Free PMC Article

Repercussions of inborn errors of immunity on growth.

Goudouris ES, Segundo GRS, Poli C
J Pediatr (Rio J) 2019 Mar-Apr;95 Suppl 1:49-58. Epub 2018 Dec 26 doi: 10.1016/j.jped.2018.11.006. PMID: 30593791

Managing Cardiovascular Risk in Lysosomal Acid Lipase Deficiency.

Maciejko JJ
Am J Cardiovasc Drugs 2017 Jun;17(3):217-231. doi: 10.1007/s40256-017-0216-5. PMID: 28197978

New aspects of vitamin K prophylaxis.

Sutor AH
Semin Thromb Hemost 2003 Aug;29(4):373-6. doi: 10.1055/s-2003-42680. PMID: 14517749

See all (33)

Diagnosis

Ramen noodle neuropathy: an atypical case of partial paralysis from malnutrition.

Lalley A, Bawa S, Harmouche E
Am J Emerg Med 2024 Jan;75:198.e7-198.e10. Epub 2023 Sep 28 doi: 10.1016/j.ajem.2023.09.039. PMID: 37805367

Etiologies of Poor Weight Gain and Ultimate Diagnosis in Children Admitted for Growth Faltering.

Peterson Lu E, Bowen J, Foglia M, Ribar E, Mack M, Sondhi E, Hickey RW
Hosp Pediatr 2023 May 1;13(5):394-402. doi: 10.1542/hpeds.2022-007038. PMID: 37082920

Repercussions of inborn errors of immunity on growth.

Goudouris ES, Segundo GRS, Poli C
J Pediatr (Rio J) 2019 Mar-Apr;95 Suppl 1:49-58. Epub 2018 Dec 26 doi: 10.1016/j.jped.2018.11.006. PMID: 30593791

Managing Cardiovascular Risk in Lysosomal Acid Lipase Deficiency.

Maciejko JJ
Am J Cardiovasc Drugs 2017 Jun;17(3):217-231. doi: 10.1007/s40256-017-0216-5. PMID: 28197978

Corticosterone methyl oxidase type II deficiency: a cause of failure to thrive and recurrent dehydration in early infancy.

Picco P, Garibaldi L, Cotellessa M, DiRocco M, Borrone C
Eur J Pediatr 1992 Mar;151(3):170-3. doi: 10.1007/BF01954376. PMID: 1601005

See all (42)

Therapy

Increased viral load in a hospitalized patient on treatment with crushed bictegravir/emtricitabine/tenofovir alafenamide: A case report and review of the literature.

Rowe SM, Clary JC, Drummond M, Derrick C, Sanasi K, Bookstaver PB
Am J Health Syst Pharm 2022 Aug 5;79(16):1330-1336. doi: 10.1093/ajhp/zxac120. PMID: 35511892

Fludarabine-based Reduced Intensity Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in a Pediatric Patient With Bone Marrow Failure Syndrome Type 3.

Barhoom D, Mohseni R, Behfar M, Hamidieh AA
J Pediatr Hematol Oncol 2022 Nov 1;44(8):e1050-e1052. Epub 2021 Dec 22 doi: 10.1097/MPH.0000000000002374. PMID: 34935734

Poor Weight Recovery Between Stage 1 Palliation and Hospital Discharge for Infants with Single Ventricle Physiology: An Analysis of the National Pediatric Cardiology Quality Improvement Collaborative Phase II Dataset.

Moza R, Truong DT, Lambert LM, Ou Z, Amula V, Eckhauser A, Minich LL, Williams RV
J Pediatr 2021 Jul;234:20-26.e2. Epub 2021 Mar 25 doi: 10.1016/j.jpeds.2021.03.035. PMID: 33774055

Parenteral Nutrition in Very Low Birth Weight Preterm Infants.

Riskin A, Hartman C, Shamir R
Isr Med Assoc J 2015 May;17(5):310-5. PMID: 26137659

New aspects of vitamin K prophylaxis.

Sutor AH
Semin Thromb Hemost 2003 Aug;29(4):373-6. doi: 10.1055/s-2003-42680. PMID: 14517749

See all (13)

Prognosis

Increased viral load in a hospitalized patient on treatment with crushed bictegravir/emtricitabine/tenofovir alafenamide: A case report and review of the literature.

Rowe SM, Clary JC, Drummond M, Derrick C, Sanasi K, Bookstaver PB
Am J Health Syst Pharm 2022 Aug 5;79(16):1330-1336. doi: 10.1093/ajhp/zxac120. PMID: 35511892

Moza R, Truong DT, Lambert LM, Ou Z, Amula V, Eckhauser A, Minich LL, Williams RV
J Pediatr 2021 Jul;234:20-26.e2. Epub 2021 Mar 25 doi: 10.1016/j.jpeds.2021.03.035. PMID: 33774055

Five-parameter evaluation of dysphagia: A novel prognostic scale for assessing neurological decline in Gaucher disease type 2.

Seehra G, Solomon B, Ryan E, Steward AM, Roshan Lal T, Tanima Y, Lopez G, Sidransky E
Mol Genet Metab 2019 Jul;127(3):191-199. Epub 2019 Jun 8 doi: 10.1016/j.ymgme.2019.06.002. PMID: 31256856 Free PMC Article

Food allergy and the gut.

Nowak-Wegrzyn A, Szajewska H, Lack G
Nat Rev Gastroenterol Hepatol 2017 Apr;14(4):241-257. Epub 2016 Dec 21 doi: 10.1038/nrgastro.2016.187. PMID: 27999436

Management of children with failure to thrive in a rural ambulatory setting. Epidemiology and growth outcomes.

Casey PH, Wortham B, Nelson JY
Clin Pediatr (Phila) 1984 Jun;23(6):325-30. doi: 10.1177/000992288402300604. PMID: 6723176

See all (11)

Clinical prediction guides

Clinical, biochemical and molecular characterization of 12 patients with pyruvate carboxylase deficiency treated with triheptanoin.

Lasio MLD, Leshinski AC, Ducich NH, Flore LA, Lehman A, Shur N, Jayakar PB, Hainline BE, Basinger AA, Wilson WG, Diaz GA, Erbe RW, Koeberl DD, Vockley J, Bedoyan JK
Mol Genet Metab 2023 Jun;139(2):107605. Epub 2023 May 9 doi: 10.1016/j.ymgme.2023.107605. PMID: 37207470 Free PMC Article

Moza R, Truong DT, Lambert LM, Ou Z, Amula V, Eckhauser A, Minich LL, Williams RV
J Pediatr 2021 Jul;234:20-26.e2. Epub 2021 Mar 25 doi: 10.1016/j.jpeds.2021.03.035. PMID: 33774055

Functional treatment of airway obstruction and feeding problems in infants with Robin sequence.

A robustified modeling approach to analyze pediatric length of stay.

Lee AH, Gracey M, Wang K, Yau KK
Ann Epidemiol 2005 Oct;15(9):673-7. doi: 10.1016/j.annepidem.2004.10.001. PMID: 16157254

Nonorganic failure to thrive in infancy: an update on nutrition, behavior, and growth.

Powell GF
J Am Coll Nutr 1988 Oct;7(5):345-53. doi: 10.1080/07315724.1988.10720251. PMID: 3053860

See all (16)