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Endometrial Large Cell Neuroendocrine Carcinoma

MedGen UID:
927120
•Concept ID:
C4289588
•
Neoplastic Process

Definition

A high grade neuroendocrine carcinoma that arises from the endometrium. It is composed of large polygonal cells arranged in well-demarcated nests, trabeculae or cords with peripheral palisading. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811

Recent clinical studies

Etiology

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy.
Akgor U, Kuru O, Sakinci M, Boyraz G, Sen S, Cakır I, Turan T, Gokcu M, Gultekin M, Sayhan S, Salman C, Ozgul N
J Gynecol Obstet Hum Reprod 2021 May;50(5):101897. Epub 2020 Aug 19 doi: 10.1016/j.jogoh.2020.101897. PMID: 32827837
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790

Diagnosis

Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy.
Akgor U, Kuru O, Sakinci M, Boyraz G, Sen S, Cakır I, Turan T, Gokcu M, Gultekin M, Sayhan S, Salman C, Ozgul N
J Gynecol Obstet Hum Reprod 2021 May;50(5):101897. Epub 2020 Aug 19 doi: 10.1016/j.jogoh.2020.101897. PMID: 32827837
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review.
Tu YA, Chen YL, Lin MC, Chen CA, Cheng WF
Taiwan J Obstet Gynecol 2018 Feb;57(1):144-149. doi: 10.1016/j.tjog.2017.12.025. PMID: 29458887
Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium.
Mulvany NJ, Allen DG
Int J Gynecol Pathol 2008 Jan;27(1):49-57. doi: 10.1097/pgp.0b013e31806219c5. PMID: 18156975
Immunohistochemistry as a diagnostic aid in cervical pathology.
McCluggage WG
Pathology 2007 Feb;39(1):97-111. doi: 10.1080/00313020601123961. PMID: 17365826

Therapy

Pathological processes and pretreatment cytologic diagnosis of neuroendocrine carcinoma of the endometrium: addendum report of the Kansai Clinical Oncology Group/Intergroup study in Japan.
Matsumoto H, Nasu K, Shikama A, Shiozaki T, Futagami M, Kai K, Mori T, Yano M, Yamada T, Teramoto N
Med Mol Morphol 2021 Sep;54(3):237-244. Epub 2021 May 2 doi: 10.1007/s00795-021-00288-4. PMID: 33934220
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma: A case report and literature review.
Hu R, Jiang J, Song G, Zhu C, Chen L, Wang C, Wang X
Medicine (Baltimore) 2019 Jul;98(29):e16433. doi: 10.1097/MD.0000000000016433. PMID: 31335697Free PMC Article
Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review.
Tu YA, Chen YL, Lin MC, Chen CA, Cheng WF
Taiwan J Obstet Gynecol 2018 Feb;57(1):144-149. doi: 10.1016/j.tjog.2017.12.025. PMID: 29458887
Large cell neuroendocrine carcinoma with sarcomatous changes of the endometrium: a case report with immunohistochemical studies and molecular genetic study of KIT and PDGFRA.
Terada T
Pathol Res Pract 2010 Jun 15;206(6):420-5. Epub 2010 Feb 26 doi: 10.1016/j.prp.2009.12.008. PMID: 20189318

Prognosis

Clinical characteristic and prognostic factors in high-grade endometrial neuroendocrine carcinoma.
Zhang Z, Wang J, Wu X, Liu Y, Xi X
J Obstet Gynaecol Res 2022 Aug;48(8):2180-2188. Epub 2022 Jul 1 doi: 10.1111/jog.15321. PMID: 35778826Free PMC Article
Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy.
Akgor U, Kuru O, Sakinci M, Boyraz G, Sen S, Cakır I, Turan T, Gokcu M, Gultekin M, Sayhan S, Salman C, Ozgul N
J Gynecol Obstet Hum Reprod 2021 May;50(5):101897. Epub 2020 Aug 19 doi: 10.1016/j.jogoh.2020.101897. PMID: 32827837
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Large-cell Neuroendocrine Carcinoma of the Endometrium in Myomatous Uterus.
Shopov ST, Anavi BL, Krastev DK
Folia Med (Plovdiv) 2020 Jun 30;62(2):412-417. doi: 10.3897/folmed.62.e49815. PMID: 32666759
Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium.
Mulvany NJ, Allen DG
Int J Gynecol Pathol 2008 Jan;27(1):49-57. doi: 10.1097/pgp.0b013e31806219c5. PMID: 18156975

Clinical prediction guides

Neuroendocrine carcinoma of the endometrium: A very rare gynecologic malignancy.
Akgor U, Kuru O, Sakinci M, Boyraz G, Sen S, Cakır I, Turan T, Gokcu M, Gultekin M, Sayhan S, Salman C, Ozgul N
J Gynecol Obstet Hum Reprod 2021 May;50(5):101897. Epub 2020 Aug 19 doi: 10.1016/j.jogoh.2020.101897. PMID: 32827837
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Small-cell neuroendocrine carcinoma in directly sampled endometrial cytology: A monocentric retrospective study of six cases.
Ebisu Y, Ishida M, Okano K, Sandoh K, Mizokami T, Kita M, Okada H, Tsuta K
Diagn Cytopathol 2019 Dec;47(12):1297-1301. Epub 2019 Aug 6 doi: 10.1002/dc.24298. PMID: 31386298
CD10 expression in the neuroendocrine carcinoma component of endometrial mixed carcinoma: association with long survival.
Uehara K, Ikehara F, Tanabe Y, Nakazato I, Oshiro M, Inamine M, Kinjo T
Diagn Pathol 2016 Feb 1;11:16. doi: 10.1186/s13000-016-0468-4. PMID: 26830028Free PMC Article
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790

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