U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hypervitaminosis A

MedGen UID:
9378
•Concept ID:
C0020579
•
Disease or Syndrome
Synonyms: hypervitaminosis A; hypervitaminosis type A
SNOMED CT: Hypervitaminosis A (64559002)
 
Monarch Initiative: MONDO:0006798

Definition

A symptom complex resulting from ingesting excessive amounts of vitamin A. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypervitaminosis A

Professional guidelines

PubMed

Spectrum of Voriconazole-Induced Periostitis With Review of the Differential Diagnosis.
Tan I, Lomasney L, Stacy GS, Lazarus M, Mar WA
AJR Am J Roentgenol 2019 Jan;212(1):157-165. Epub 2018 Nov 7 doi: 10.2214/AJR.18.19991. PMID: 30403528
Clinical spectrum of the pseudotumor cerebri in children: etiological, clinical features, treatment and prognosis.
Per H, Canpolat M, Gümüş H, Poyrazoğlu HG, Yıkılmaz A, Karaküçük S, Doğan H, Kumandaş S
Brain Dev 2013 Jun;35(6):561-8. Epub 2012 Sep 13 doi: 10.1016/j.braindev.2012.08.008. PMID: 22981259
Isotretinoin (roaccutane) usage--a South African consensus guideline. National Dermatology Working Group.
S Afr Med J 1997 Oct;87(10 Pt 2):1410-3. PMID: 11496385

Recent clinical studies

Etiology

Hypervitaminosis A in Pediatric Patients With Advanced Chronic Kidney Disease.
Harris M, Varnell C, Taylor V, Nehus ST, Zhang B, Erkan E
J Ren Nutr 2022 May;32(3):275-281. Epub 2021 Jun 5 doi: 10.1053/j.jrn.2021.03.010. PMID: 34103212Free PMC Article
Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study.
Melliez H, Prost M, Behal H, Neveux N, Benoist JF, Kim I, Mazzella S, Derdour V, Sauser E, Robineau O, Senneville E, Cynober L, Biekre R, Seguy D
Eur J Clin Microbiol Infect Dis 2020 Nov;39(11):2091-2098. Epub 2020 Jun 30 doi: 10.1007/s10096-020-03954-0. PMID: 32607910
Vitamin A and Wound Healing.
Zinder R, Cooley R, Vlad LG, Molnar JA
Nutr Clin Pract 2019 Dec;34(6):839-849. doi: 10.1002/ncp.10420. PMID: 31697447
Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.
Mawson AR, Croft AM
Int J Environ Res Public Health 2019 Sep 22;16(19) doi: 10.3390/ijerph16193543. PMID: 31546693Free PMC Article
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Diagnosis

Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.
Mawson AR, Croft AM
Int J Environ Res Public Health 2019 Sep 22;16(19) doi: 10.3390/ijerph16193543. PMID: 31546693Free PMC Article
Insights of hypercarotenaemia: A brief review.
Priyadarshani AMB
Clin Nutr ESPEN 2018 Feb;23:19-24. Epub 2017 Dec 19 doi: 10.1016/j.clnesp.2017.12.002. PMID: 29460797
Hypertrophic Osteoarthropathy: Clinical and Imaging Features.
Yap FY, Skalski MR, Patel DB, Schein AJ, White EA, Tomasian A, Masih S, Matcuk GR Jr
Radiographics 2017 Jan-Feb;37(1):157-195. Epub 2016 Dec 9 doi: 10.1148/rg.2017160052. PMID: 27935768
Vitamins.
Sethuraman U
Pediatr Rev 2006 Feb;27(2):44-55. doi: 10.1542/pir.27-2-44. PMID: 16452274
Secondary causes of osteoporosis.
Fitzpatrick LA
Mayo Clin Proc 2002 May;77(5):453-68. doi: 10.4065/77.5.453. PMID: 12004995

Therapy

Vitamin A and Wound Healing.
Zinder R, Cooley R, Vlad LG, Molnar JA
Nutr Clin Pract 2019 Dec;34(6):839-849. doi: 10.1002/ncp.10420. PMID: 31697447
Vitamin A: too much of a good thing?
Duerbeck NB, Dowling DD
Obstet Gynecol Surv 2012 Feb;67(2):122-8. doi: 10.1097/OGX.0b013e318244c52d. PMID: 22325302
Hypervitaminosis A and bone.
Binkley N, Krueger D
Nutr Rev 2000 May;58(5):138-44. doi: 10.1111/j.1753-4887.2000.tb01848.x. PMID: 10860393
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588
Vitamin A.
Schoeff L
Am J Med Technol 1983 Jun;49(6):447-52. PMID: 6349358

Prognosis

Chronic and acute hypervitaminosis A are associated with suboptimal anthropometric measurements in a cohort of South African preschool children.
Sheftel J, van Stuijvenberg ME, Dhansay MA, Suri DJ, Grahn M, Keuler NS, Binkley NC, Tanumihardjo SA
Am J Clin Nutr 2022 Apr 1;115(4):1059-1068. doi: 10.1093/ajcn/nqab422. PMID: 35030234
Hypertrophic Osteoarthropathy: Clinical and Imaging Features.
Yap FY, Skalski MR, Patel DB, Schein AJ, White EA, Tomasian A, Masih S, Matcuk GR Jr
Radiographics 2017 Jan-Feb;37(1):157-195. Epub 2016 Dec 9 doi: 10.1148/rg.2017160052. PMID: 27935768
Hypervitaminosis A is prevalent in children with CKD and contributes to hypercalcemia.
Manickavasagar B, McArdle AJ, Yadav P, Shaw V, Dixon M, Blomhoff R, Connor GO, Rees L, Ledermann S, Van't Hoff W, Shroff R
Pediatr Nephrol 2015 Feb;30(2):317-25. Epub 2014 Aug 15 doi: 10.1007/s00467-014-2916-2. PMID: 25119682Free PMC Article
Idiopathic intracranial hypertension (pseudotumor cerebri).
Wall M
Curr Neurol Neurosci Rep 2008 Mar;8(2):87-93. PMID: 18460275
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Clinical prediction guides

Chronic and acute hypervitaminosis A are associated with suboptimal anthropometric measurements in a cohort of South African preschool children.
Sheftel J, van Stuijvenberg ME, Dhansay MA, Suri DJ, Grahn M, Keuler NS, Binkley NC, Tanumihardjo SA
Am J Clin Nutr 2022 Apr 1;115(4):1059-1068. doi: 10.1093/ajcn/nqab422. PMID: 35030234
The Need to Consider Context in the Evaluation of Anti-infectious and Immunomodulatory Effects of Vitamin A and its Derivatives.
Xavier-Elsas P, Vieira BM, Masid-de-Brito D, Barradas MG, Gaspar-Elsas MIC
Curr Drug Targets 2019;20(8):871-878. doi: 10.2174/1389450120666181217095323. PMID: 30556501
Hypervitaminosis A is prevalent in children with CKD and contributes to hypercalcemia.
Manickavasagar B, McArdle AJ, Yadav P, Shaw V, Dixon M, Blomhoff R, Connor GO, Rees L, Ledermann S, Van't Hoff W, Shroff R
Pediatr Nephrol 2015 Feb;30(2):317-25. Epub 2014 Aug 15 doi: 10.1007/s00467-014-2916-2. PMID: 25119682Free PMC Article
Adverse effects of antioxidative vitamins.
Rutkowski M, Grzegorczyk K
Int J Occup Med Environ Health 2012 Jun;25(2):105-21. Epub 2012 Apr 19 doi: 10.2478/S13382-012-0022-x. PMID: 22528540
Vitamin neurotoxicity.
Snodgrass SR
Mol Neurobiol 1992 Spring;6(1):41-73. doi: 10.1007/BF02935566. PMID: 1463588

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...