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Chronic hepatitis C virus infection

MedGen UID:
964868
•Concept ID:
CN281762
•
Disease or Syndrome
Synonyms: chronic Hepatitis C; chronic hepatitis C virus infection; hepatitis C infection, chronic; hepatitis C, chronic
 
Monarch Initiative: MONDO:0005354

Definition

Chronic form of hepatitis C infection. [from MONDO]

Professional guidelines

PubMed

Viral Hepatitis: Etiology, Epidemiology, Transmission, Diagnostics, Treatment, and Prevention.
Lanini S, Ustianowski A, Pisapia R, Zumla A, Ippolito G
Infect Dis Clin North Am 2019 Dec;33(4):1045-1062. doi: 10.1016/j.idc.2019.08.004. PMID: 31668190
Global Epidemiology, Prevention, and Management of Hepatocellular Carcinoma.
Mak LY, Cruz-Ramón V, Chinchilla-López P, Torres HA, LoConte NK, Rice JP, Foxhall LE, Sturgis EM, Merrill JK, Bailey HH, Méndez-Sánchez N, Yuen MF, Hwang JP
Am Soc Clin Oncol Educ Book 2018 May 23;38:262-279. doi: 10.1200/EDBK_200939. PMID: 30231359
Treatment of early stage chronic hepatitis C virus infection.
Ponziani FR, Miele L, Tortora A, Furnari M, Bodini G, Pompili M, Gasbarrini A, Giannini EG
Expert Rev Clin Pharmacol 2018 May;11(5):519-524. Epub 2018 Mar 9 doi: 10.1080/17512433.2018.1447923. PMID: 29498556

Recent clinical studies

Etiology

Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response.
Montaldo C, Terri M, Riccioni V, Battistelli C, Bordoni V, D'Offizi G, Prado MG, Trionfetti F, Vescovo T, Tartaglia E, Strippoli R, Agrati C, Tripodi M
J Hepatol 2021 Dec;75(6):1301-1311. Epub 2021 Jul 13 doi: 10.1016/j.jhep.2021.07.003. PMID: 34271004
Treatment of early stage chronic hepatitis C virus infection.
Ponziani FR, Miele L, Tortora A, Furnari M, Bodini G, Pompili M, Gasbarrini A, Giannini EG
Expert Rev Clin Pharmacol 2018 May;11(5):519-524. Epub 2018 Mar 9 doi: 10.1080/17512433.2018.1447923. PMID: 29498556
Immunotherapy for Chronic Hepatitis B Virus Infection.
Bertoletti A, Le Bert N
Gut Liver 2018 Sep 15;12(5):497-507. doi: 10.5009/gnl17233. PMID: 29316747Free PMC Article
Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma.
Bandiera S, Billie Bian C, Hoshida Y, Baumert TF, Zeisel MB
Curr Opin Virol 2016 Oct;20:99-105. Epub 2016 Oct 11 doi: 10.1016/j.coviro.2016.09.010. PMID: 27741441Free PMC Article
Immune regulation in chronic hepatitis C virus infection.
Hartling HJ, Ballegaard VC, Nielsen NS, Gaardbo JC, Nielsen SD
Scand J Gastroenterol 2016 Nov;51(11):1387-97. Epub 2016 Jul 19 doi: 10.3109/00365521.2016.1170875. PMID: 27436030

Diagnosis

Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review.
Babiker A, Hassan M, Muhammed S, Taylor G, Poonia B, Shah A, Bagchi S
Clin Cardiol 2020 Mar;43(3):222-234. Epub 2019 Nov 30 doi: 10.1002/clc.23299. PMID: 31785111Free PMC Article
Chronic kidney disease in patients with chronic hepatitis C virus infection.
Shahab O, Golabi P, Younossi ZM
Minerva Gastroenterol Dietol 2018 Dec;64(4):376-382. Epub 2018 Jan 10 doi: 10.23736/S1121-421X.18.02466-2. PMID: 29327821
Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection.
Flores-Chávez A, Carrion JA, Forns X, Ramos-Casals M
Rev Esp Sanid Penit 2017 Dec;19(3):87-97. doi: 10.4321/S1575-06202017000300004. PMID: 29364334Free PMC Article
Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage.
Valva P, Ríos DA, De Matteo E, Preciado MV
World J Gastroenterol 2016 Jan 28;22(4):1367-81. doi: 10.3748/wjg.v22.i4.1367. PMID: 26819506Free PMC Article
Chronic hepatitis C virus infection and lipoprotein metabolism.
Aizawa Y, Seki N, Nagano T, Abe H
World J Gastroenterol 2015 Sep 28;21(36):10299-313. doi: 10.3748/wjg.v21.i36.10299. PMID: 26420957Free PMC Article

Therapy

Hepatitis C Virus Envelope Glycoproteins: A Balancing Act of Order and Disorder.
Yost SA, Wang Y, Marcotrigiano J
Front Immunol 2018;9:1917. Epub 2018 Aug 24 doi: 10.3389/fimmu.2018.01917. PMID: 30197646Free PMC Article
Treatment of early stage chronic hepatitis C virus infection.
Ponziani FR, Miele L, Tortora A, Furnari M, Bodini G, Pompili M, Gasbarrini A, Giannini EG
Expert Rev Clin Pharmacol 2018 May;11(5):519-524. Epub 2018 Mar 9 doi: 10.1080/17512433.2018.1447923. PMID: 29498556
Immunotherapy for Chronic Hepatitis B Virus Infection.
Bertoletti A, Le Bert N
Gut Liver 2018 Sep 15;12(5):497-507. doi: 10.5009/gnl17233. PMID: 29316747Free PMC Article
Chronic Hepatitis C Virus Infection and Depression.
Adinolfi LE, Nevola R, Rinaldi L, Romano C, Giordano M
Clin Liver Dis 2017 Aug;21(3):517-534. Epub 2017 Apr 25 doi: 10.1016/j.cld.2017.03.007. PMID: 28689590
Interferon-lambda and therapy for chronic hepatitis C virus infection.
Donnelly RP, Dickensheets H, O'Brien TR
Trends Immunol 2011 Sep;32(9):443-50. Epub 2011 Aug 5 doi: 10.1016/j.it.2011.07.002. PMID: 21820962Free PMC Article

Prognosis

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.
Mazzaro C, Quartuccio L, Adinolfi LE, Roccatello D, Pozzato G, Nevola R, Tonizzo M, Gitto S, Andreone P, Gattei V
Viruses 2021 Nov 9;13(11) doi: 10.3390/v13112249. PMID: 34835054Free PMC Article
Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review.
Babiker A, Hassan M, Muhammed S, Taylor G, Poonia B, Shah A, Bagchi S
Clin Cardiol 2020 Mar;43(3):222-234. Epub 2019 Nov 30 doi: 10.1002/clc.23299. PMID: 31785111Free PMC Article
Liver stiffness in chronic hepatitis C virus infection.
Mihăilă RG
Rom J Intern Med 2019 Jun 1;57(2):85-98. doi: 10.2478/rjim-2018-0034. PMID: 30447147
Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection.
Flores-Chávez A, Carrion JA, Forns X, Ramos-Casals M
Rev Esp Sanid Penit 2017 Dec;19(3):87-97. doi: 10.4321/S1575-06202017000300004. PMID: 29364334Free PMC Article
Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage.
Valva P, Ríos DA, De Matteo E, Preciado MV
World J Gastroenterol 2016 Jan 28;22(4):1367-81. doi: 10.3748/wjg.v22.i4.1367. PMID: 26819506Free PMC Article

Clinical prediction guides

Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response.
Montaldo C, Terri M, Riccioni V, Battistelli C, Bordoni V, D'Offizi G, Prado MG, Trionfetti F, Vescovo T, Tartaglia E, Strippoli R, Agrati C, Tripodi M
J Hepatol 2021 Dec;75(6):1301-1311. Epub 2021 Jul 13 doi: 10.1016/j.jhep.2021.07.003. PMID: 34271004
Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review.
Babiker A, Hassan M, Muhammed S, Taylor G, Poonia B, Shah A, Bagchi S
Clin Cardiol 2020 Mar;43(3):222-234. Epub 2019 Nov 30 doi: 10.1002/clc.23299. PMID: 31785111Free PMC Article
Liver stiffness in chronic hepatitis C virus infection.
Mihăilă RG
Rom J Intern Med 2019 Jun 1;57(2):85-98. doi: 10.2478/rjim-2018-0034. PMID: 30447147
Chronic Hepatitis C Virus Infection and Depression.
Adinolfi LE, Nevola R, Rinaldi L, Romano C, Giordano M
Clin Liver Dis 2017 Aug;21(3):517-534. Epub 2017 Apr 25 doi: 10.1016/j.cld.2017.03.007. PMID: 28689590
Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage.
Valva P, Ríos DA, De Matteo E, Preciado MV
World J Gastroenterol 2016 Jan 28;22(4):1367-81. doi: 10.3748/wjg.v22.i4.1367. PMID: 26819506Free PMC Article

Recent systematic reviews

Association Between Chronic Hepatitis C Virus Infection and Esophageal Cancer: A Systematic Review and Meta-analysis.
Ponvilawan B, Rittiphairoj T, Charoenngam N, Rujirachun P, Wattanachayakul P, Tornsatitkul S, Ungprasert P
J Clin Gastroenterol 2022 Jan 1;56(1):55-63. doi: 10.1097/MCG.0000000000001532. PMID: 33780211
Global cascade of care for chronic hepatitis C virus infection: A systematic review and meta-analysis.
Yousafzai MT, Bajis S, Alavi M, Grebely J, Dore GJ, Hajarizadeh B
J Viral Hepat 2021 Oct;28(10):1340-1354. Epub 2021 Jul 31 doi: 10.1111/jvh.13574. PMID: 34310812
Chronic Hepatitis C Virus Infection is Associated with an Increased Risk of Lung Cancer: A Systematic Review and Meta-analysis.
Ponvilawan B, Charoenngam N, Rujirachun P, Wattanachayakul P, Tornsatitkul S, Rittiphairoj T, Ungprasert P
Lung 2020 Aug;198(4):705-714. Epub 2020 Jun 4 doi: 10.1007/s00408-020-00365-y. PMID: 32500315
Safety and efficacy of sofosbuvir plus velpatasvir with or without ribavirin for chronic hepatitis C virus infection: A systematic review and meta-analysis.
Ahmed H, Abushouk AI, Attia A, Gadelkarim M, Gabr M, Negida A, Abdel-Daim MM
J Infect Public Health 2018 Mar-Apr;11(2):156-164. Epub 2017 Sep 29 doi: 10.1016/j.jiph.2017.09.004. PMID: 28970099
Nitazoxanide for chronic hepatitis C.
Nikolova K, Gluud C, Grevstad B, Jakobsen JC
Cochrane Database Syst Rev 2014 Apr 6;2014(4):CD009182. doi: 10.1002/14651858.CD009182.pub2. PMID: 24706397Free PMC Article

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