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Papillary Neoplasm

MedGen UID:
96902
•Concept ID:
C0476073
•
Neoplastic Process
Synonyms: Papillary neoplasm; Papillary tumor; Papillary Tumor
SNOMED CT: Papillary neoplasm (442172002); Papillary tumor (442172002)

Definition

A benign, intermediate, or malignant neoplasm characterized by the formation of papillary structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPapillary Neoplasm

Professional guidelines

PubMed

Differential Diagnosis of Benign and Malignant Breast Papillary Neoplasms on MRI With Non-mass Enhancement.
Zhou J, Li M, Liu D, Sheng F, Cai J
Acad Radiol 2023 Sep;30 Suppl 2:S127-S132. Epub 2023 Mar 9 doi: 10.1016/j.acra.2023.02.010. PMID: 36906443
Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.
Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790
Primary Liver Cancers-Part 1: Histopathology, Differential Diagnoses, and Risk Stratification.
Jiang K, Al-Diffhala S, Centeno BA
Cancer Control 2018 Jan-Mar;25(1):1073274817744625. doi: 10.1177/1073274817744625. PMID: 29350068Free PMC Article

Recent clinical studies

Etiology

Intraductal neoplasms of the pancreatobiliary tract: navigating the alphabet.
Xue Y, Basturk O
Histopathology 2023 Oct;83(4):499-508. Epub 2023 Jul 16 doi: 10.1111/his.15003. PMID: 37455382
Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features.
Stendahl K, Gilani SM, Basturk O, Hui P, Sigel C, Cai G
Cancer Cytopathol 2023 Jan;131(1):37-49. Epub 2022 Aug 30 doi: 10.1002/cncy.22637. PMID: 36041224Free PMC Article
Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Pathology of intraductal papillary mucinous neoplasms.
Assarzadegan N, Thompson E, Salimian K, Gaida MM, Brosens LAA, Wood L, Ali SZ, Hruban RH
Langenbecks Arch Surg 2021 Dec;406(8):2643-2655. Epub 2021 May 28 doi: 10.1007/s00423-021-02201-0. PMID: 34047827Free PMC Article
Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.
Lendvai G, Szekerczés T, Illyés I, Dóra R, Kontsek E, Gógl A, Kiss A, Werling K, Kovalszky I, Schaff Z, Borka K
Pathol Oncol Res 2020 Jan;26(1):3-15. Epub 2018 Nov 17 doi: 10.1007/s12253-018-0491-8. PMID: 30448973

Diagnosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features.
Stendahl K, Gilani SM, Basturk O, Hui P, Sigel C, Cai G
Cancer Cytopathol 2023 Jan;131(1):37-49. Epub 2022 Aug 30 doi: 10.1002/cncy.22637. PMID: 36041224Free PMC Article
Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D
Surg Pathol Clin 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. PMID: 36049837
Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct.
Sakai Y, Ohtsuka M, Sugiyama H, Mikata R, Yasui S, Ohno I, Iino Y, Kato J, Tsuyuguchi T, Kato N
World J Gastroenterol 2021 Apr 21;27(15):1569-1577. doi: 10.3748/wjg.v27.i15.1569. PMID: 33958844Free PMC Article

Therapy

Precancerous Lesions and Liver Atrophy as Risk Factors for Hepatolithiasis-Related Death after Liver Resection for Hepatolithiasis.
Miyazaki T, Shinkawa H, Takemura S, Tanaka S, Amano R, Kimura K, Ohira G, Nishio K, Kinoshita M, Tsuchi J, Ishihara A, Eguchi S, Shirai D, Yamamoto T, Wakasa K, Kawada N, Kubo S
Asian Pac J Cancer Prev 2020 Dec 1;21(12):3647-3654. doi: 10.31557/APJCP.2020.21.12.3647. PMID: 33369464Free PMC Article
Unusual recurrent metastasizing benign breast papilloma: a case report.
Jain AL, Mullins J, Smith JR, Valasareddy P, Miller E, Chaudhry A, Ryder J, Hare F, Ranganath H, Berry M, Robins D, Schwartzberg L, Vidal GA
J Med Case Rep 2020 Feb 19;14(1):33. doi: 10.1186/s13256-020-2354-7. PMID: 32070435Free PMC Article
Association between Repeated Praziquantel treatment and Papillary, and Intrahepatic Cholangiocarcinoma.
Luvira V, Kamsa-Ard S, Kamsa-Ard S, Luvira V, Srisuk T, Pugkhem A, Pairojkul C, Bhudhisawasdi V
Ann Hepatol 2018 Aug 24;17(5):802-809. doi: 10.5604/01.3001.0012.3140. PMID: 30145559
Intraductal papillary neoplasm of the bile duct : case report and review of the literature.
Apostolopoulos P, Ekmektzoglou KA, Paraskeva K, Dimopoulos K, Paparaskeva K, Alexandrakis G
Acta Gastroenterol Belg 2018 Jan-Mar;81(1):97-99. PMID: 29562383
Outcomes after resection of occupational cholangiocarcinoma.
Kubo S, Takemura S, Tanaka S, Shinkawa H, Kinoshita M, Hamano G, Ito T, Koda M, Aota T, Yamamoto T, Terajima H, Tachiyama G, Yamada T, Nakamori S, Arimoto A, Fujikawa M, Tomimaru Y, Sugawara Y, Nakagawa K, Unno M, Mizuguchi T, Takenaka K, Kimura K, Shirabe K, Saiura A, Uesaka K, Taniguchi H, Fukuda A, Chong JM, Kuwae Y, Ohsawa M, Sato Y, Nakanuma Y
J Hepatobiliary Pancreat Sci 2016 Sep;23(9):556-64. Epub 2016 Aug 1 doi: 10.1002/jhbp.373. PMID: 27363864

Prognosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
Intraductal neoplasms of the pancreatobiliary tract: navigating the alphabet.
Xue Y, Basturk O
Histopathology 2023 Oct;83(4):499-508. Epub 2023 Jul 16 doi: 10.1111/his.15003. PMID: 37455382
The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D
Surg Pathol Clin 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. PMID: 36049837
A Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract.
Ozcan K, Klimstra DS
Arch Pathol Lab Med 2022 Mar 1;146(3):298-311. doi: 10.5858/arpa.2021-0399-RA. PMID: 35192699
Precursor Lesions of Pancreatic Cancer.
Kim JY, Hong SM
Oncol Res Treat 2018;41(10):603-610. Epub 2018 Sep 28 doi: 10.1159/000493554. PMID: 30269131

Clinical prediction guides

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Peribiliary glands: development, dysfunction, related conditions and imaging findings.
Matsubara T, Kozaka K, Matsui O, Nakanuma Y, Uesaka K, Inoue D, Yoneda N, Yoshida K, Kitao A, Yokka A, Koda W, Gabata T, Kobayashi S
Abdom Radiol (NY) 2020 Feb;45(2):416-436. doi: 10.1007/s00261-019-02298-4. PMID: 31707436
"Biliary Diseases with Pancreatic Counterparts": Cross-sectional Imaging Findings.
Katabathina VS, Flaherty EM, Dasyam AK, Menias CO, Riddle ND, Lath N, Kozaka K, Matsui O, Nakanuma Y, Prasad SR
Radiographics 2016 Mar-Apr;36(2):374-92. Epub 2016 Feb 1 doi: 10.1148/rg.2016150071. PMID: 26824512
Intraductal papillary neoplasm of the bile duct.
Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, Zhao HT, Sang XT
World J Gastroenterol 2013 Dec 14;19(46):8595-604. doi: 10.3748/wjg.v19.i46.8595. PMID: 24379576Free PMC Article
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Recent systematic reviews

Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review.
Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458
Intraductal oncocytic papillary neoplasm of the pancreas: A systematic review.
Wang YZ, Lu J, Jiang BL, Guo JC
Pancreatology 2019 Sep;19(6):858-865. Epub 2019 Jul 27 doi: 10.1016/j.pan.2019.07.040. PMID: 31375434
Systematic Review and Meta-analysis of Current Experience in Treating IPNB: Clinical and Pathological Correlates.
Gordon-Weeks AN, Jones K, Harriss E, Smith A, Silva M
Ann Surg 2016 Apr;263(4):656-63. doi: 10.1097/SLA.0000000000001426. PMID: 26501712

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