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Loose anagen hair syndrome

MedGen UID:
98351
Concept ID:
C0406468
Disease or Syndrome
Synonym: Loose anagen syndrome
SNOMED CT: Loose anagen hair syndrome (238735005)
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
 
Monarch Initiative: MONDO:0010908
OMIM®: 600628
Orphanet: ORPHA168

Definition

Loose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoose anagen hair syndrome
Follow this link to review classifications for Loose anagen hair syndrome in Orphanet.

Professional guidelines

PubMed

Villani A, Fabbrocini G, Ocampo-Candiani J, Ruggiero A, Ocampo-Garza SS
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1485-1492. Epub 2021 Mar 23 doi: 10.1111/jdv.17216. PMID: 33660357
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136

Recent clinical studies

Etiology

Randolph MJ, Gwillim EC, Nguyen B, Tosti A
Pediatr Dermatol 2022 Jul;39(4):567-569. Epub 2022 Apr 16 doi: 10.1111/pde.15002. PMID: 35429064Free PMC Article
Huckstadt V, Chinton J, Gomez A, Obregon MG, Gravina LP
Am J Med Genet A 2021 Apr;185(4):1256-1260. Epub 2021 Jan 25 doi: 10.1002/ajmg.a.62089. PMID: 33491856
Swink SM, Castelo-Soccio L
Pediatr Dermatol 2016 Sep;33(5):507-10. Epub 2016 Jul 19 doi: 10.1111/pde.12912. PMID: 27436070
Alves R, Grimalt R
Curr Probl Dermatol 2015;47:55-66. Epub 2015 Feb 20 doi: 10.1159/000369405. PMID: 26370644
Abdel-Raouf H, El-Din WH, Awad SS, Esmat A, Al-Khiat M, Abdel-Wahab H, Fakahani H, Al-Domyati M, El-Din Anber T, El-Tonsy MH
J Cosmet Dermatol 2009 Jun;8(2):103-7. doi: 10.1111/j.1473-2165.2009.00434.x. PMID: 19527333

Diagnosis

Alsabbagh MM
Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):49-64. PMID: 35751533
Zarbo A, Shwayder T
J Pediatr 2018 Aug;199:282-282.e1. Epub 2018 Apr 25 doi: 10.1016/j.jpeds.2018.03.005. PMID: 29705113
Alves R, Grimalt R
Curr Probl Dermatol 2015;47:55-66. Epub 2015 Feb 20 doi: 10.1159/000369405. PMID: 26370644
Kanwar AJ, Narang T
Indian J Dermatol Venereol Leprol 2013 Sep-Oct;79(5):604-12. doi: 10.4103/0378-6323.116728. PMID: 23974578
Tartaglia M, Gelb BD, Zenker M
Best Pract Res Clin Endocrinol Metab 2011 Feb;25(1):161-79. doi: 10.1016/j.beem.2010.09.002. PMID: 21396583Free PMC Article

Therapy

Villani A, Fabbrocini G, Ocampo-Candiani J, Ruggiero A, Ocampo-Garza SS
J Eur Acad Dermatol Venereol 2021 Jul;35(7):1485-1492. Epub 2021 Mar 23 doi: 10.1111/jdv.17216. PMID: 33660357
Randolph M, Tosti A
J Am Acad Dermatol 2021 Mar;84(3):737-746. Epub 2020 Jul 2 doi: 10.1016/j.jaad.2020.06.1009. PMID: 32622136
Zhou P, Zhu L, Fan Q, Liu Y, Zhang T, Yang T, Chen J, Cheng Q, Li T, Chen L
Am J Med Genet A 2020 Aug;182(8):1967-1971. Epub 2020 Jun 1 doi: 10.1002/ajmg.a.61638. PMID: 32476286
Alves R, Grimalt R
Curr Probl Dermatol 2015;47:55-66. Epub 2015 Feb 20 doi: 10.1159/000369405. PMID: 26370644
Zmolikova M, Puchmajerova A, Hecht P, Lebl J, Trkova M, Krepelova A
Am J Med Genet A 2014 May;164A(5):1218-21. Epub 2014 Jan 23 doi: 10.1002/ajmg.a.36404. PMID: 24458596

Prognosis

Biard JM, Steenhaut P, Bernard P, Race V, Sznajer Y
Eur J Obstet Gynecol Reprod Biol 2019 Sep;240:232-241. Epub 2019 Jul 16 doi: 10.1016/j.ejogrb.2019.06.035. PMID: 31336229
Swink SM, Castelo-Soccio L
Pediatr Dermatol 2016 Sep;33(5):507-10. Epub 2016 Jul 19 doi: 10.1111/pde.12912. PMID: 27436070
Zmolikova M, Puchmajerova A, Hecht P, Lebl J, Trkova M, Krepelova A
Am J Med Genet A 2014 May;164A(5):1218-21. Epub 2014 Jan 23 doi: 10.1002/ajmg.a.36404. PMID: 24458596
Mirmirani P, Uno H, Price VH
J Am Acad Dermatol 2011 Jan;64(1):129-34. doi: 10.1016/j.jaad.2010.01.026. PMID: 21167408
Cantatore-Francis JL, Orlow SJ
Arch Dermatol 2009 Oct;145(10):1123-8. doi: 10.1001/archdermatol.2009.220. PMID: 19841399

Clinical prediction guides

Alsabbagh MM
Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):49-64. PMID: 35751533
Motta M, Solman M, Bonnard AA, Kuechler A, Pantaleoni F, Priolo M, Chandramouli B, Coppola S, Pizzi S, Zara E, Ferilli M, Kayserili H, Onesimo R, Leoni C, Brinkmann J, Vial Y, Kamphausen SB, Thomas-Teinturier C, Guimier A, Cordeddu V, Mazzanti L, Zampino G, Chillemi G, Zenker M, Cavé H, den Hertog J, Tartaglia M
Hum Mol Genet 2022 Aug 23;31(16):2766-2778. doi: 10.1093/hmg/ddac071. PMID: 35348676Free PMC Article
Alves R, Grimalt R
Curr Probl Dermatol 2015;47:55-66. Epub 2015 Feb 20 doi: 10.1159/000369405. PMID: 26370644
Zmolikova M, Puchmajerova A, Hecht P, Lebl J, Trkova M, Krepelova A
Am J Med Genet A 2014 May;164A(5):1218-21. Epub 2014 Jan 23 doi: 10.1002/ajmg.a.36404. PMID: 24458596
Baden HP, Kvedar JC, Magro CM
Arch Dermatol 1992 Oct;128(10):1349-53. PMID: 1417022

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