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Focal motor seizure with version

MedGen UID:
98387
•Concept ID:
C0422846
•
Disease or Syndrome
Synonyms: Seizure, Versive; Seizures, Versive; Versive Seizure; Versive Seizures
SNOMED CT: Focal onset motor onset versive epileptic seizure (246530009); Focal onset versive epileptic seizure (246530009); Focal-onset motor-onset versive epileptic seizure (246530009); Focal versive seizure (246530009)
 
HPO: HP:0011175

Definition

A type of focal motor seizure characterized by sustained, forced conjugate ocular, cephalic, and/or truncal rotation or lateral deviation from the midline as the initial semiological manifestation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal motor seizure with version

Professional guidelines

PubMed

Rasmussen's encephalitis: Early diagnostic criteria in children.
Villeneuve N, Lépine A, Girard N, Guedj E, Daquin G
Rev Neurol (Paris) 2022 Sep;178(7):666-674. Epub 2022 May 11 doi: 10.1016/j.neurol.2022.03.012. PMID: 35568516
Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents.
Hon KL, Leung AKC, Torres AR
Recent Pat Inflamm Allergy Drug Discov 2018;12(2):128-135. doi: 10.2174/1872213X12666180508122450. PMID: 29745347
From genotype to phenotype in Dravet disease.
Gataullina S, Dulac O
Seizure 2017 Jan;44:58-64. Epub 2016 Oct 21 doi: 10.1016/j.seizure.2016.10.014. PMID: 27817982

Recent clinical studies

Etiology

Fine motor impairment in children with epilepsy: Relations with seizure severity and lateralizing value.
David CV, MacAllister WS
Epilepsy Behav 2022 Feb;127:108518. Epub 2022 Jan 8 doi: 10.1016/j.yebeh.2021.108518. PMID: 35016052
Epilepsy Surgery in Children.
Bello-Espinosa LE, Olavarria G
Pediatr Clin North Am 2021 Aug;68(4):845-856. doi: 10.1016/j.pcl.2021.04.016. PMID: 34247713
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103
Seizure outcome following primary motor cortex-sparing resective surgery for perirolandic focal cortical dysplasia.
Gopinath S, Roy AG, Vinayan KP, Kumar A, Sarma M, Rajeshkannan R, Pillai A
Int J Surg 2016 Dec;36(Pt B):466-476. Epub 2015 Nov 2 doi: 10.1016/j.ijsu.2015.10.036. PMID: 26542986

Diagnosis

Motor seizure semiology.
Wu S, Nordli DR
Handb Clin Neurol 2023;196:295-304. doi: 10.1016/B978-0-323-98817-9.00014-4. PMID: 37620075
Frontal lobe seizures: overview and update.
McGonigal A
J Neurol 2022 Jun;269(6):3363-3371. Epub 2022 Jan 10 doi: 10.1007/s00415-021-10949-0. PMID: 35006387
Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents.
Hon KL, Leung AKC, Torres AR
Recent Pat Inflamm Allergy Drug Discov 2018;12(2):128-135. doi: 10.2174/1872213X12666180508122450. PMID: 29745347
Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis.
D'Antonio F, Pagani G, Familiari A, Khalil A, Sagies TL, Malinger G, Leibovitz Z, Garel C, Moutard ML, Pilu G, Bhide A, Acharya G, Leombroni M, Manzoli L, Papageorghiou A, Prefumo F
Pediatrics 2016 Sep;138(3) doi: 10.1542/peds.2016-0445. PMID: 27581855
Semiological seizure classification.
Lüders H, Acharya J, Baumgartner C, Benbadis S, Bleasel A, Burgess R, Dinner DS, Ebner A, Foldvary N, Geller E, Hamer H, Holthausen H, Kotagal P, Morris H, Meencke HJ, Noachtar S, Rosenow F, Sakamoto A, Steinhoff BJ, Tuxhorn I, Wyllie E
Epilepsia 1998 Sep;39(9):1006-13. doi: 10.1111/j.1528-1157.1998.tb01452.x. PMID: 9738682

Therapy

Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.
Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485Free PMC Article
Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.
Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103
Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents.
Hon KL, Leung AKC, Torres AR
Recent Pat Inflamm Allergy Drug Discov 2018;12(2):128-135. doi: 10.2174/1872213X12666180508122450. PMID: 29745347
Lacosamide in status epilepticus: Systematic review of current evidence.
Strzelczyk A, Zöllner JP, Willems LM, Jost J, Paule E, Schubert-Bast S, Rosenow F, Bauer S
Epilepsia 2017 Jun;58(6):933-950. Epub 2017 Mar 11 doi: 10.1111/epi.13716. PMID: 28295226
Monitoring neonatal seizures.
Boylan GB, Stevenson NJ, Vanhatalo S
Semin Fetal Neonatal Med 2013 Aug;18(4):202-8. Epub 2013 May 24 doi: 10.1016/j.siny.2013.04.004. PMID: 23707519

Prognosis

Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
Frontal lobe seizures: overview and update.
McGonigal A
J Neurol 2022 Jun;269(6):3363-3371. Epub 2022 Jan 10 doi: 10.1007/s00415-021-10949-0. PMID: 35006387
Adult phenotype of KCNQ2 encephalopathy.
Boets S, Johannesen KM, Destree A, Manti F, Ramantani G, Lesca G, Vercueil L, Koenig MK, Striano P, Møller RS, Cooper E, Weckhuysen S
J Med Genet 2022 Jun;59(6):528-535. Epub 2021 Apr 2 doi: 10.1136/jmedgenet-2020-107449. PMID: 33811133
Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents.
Hon KL, Leung AKC, Torres AR
Recent Pat Inflamm Allergy Drug Discov 2018;12(2):128-135. doi: 10.2174/1872213X12666180508122450. PMID: 29745347
From genotype to phenotype in Dravet disease.
Gataullina S, Dulac O
Seizure 2017 Jan;44:58-64. Epub 2016 Oct 21 doi: 10.1016/j.seizure.2016.10.014. PMID: 27817982

Clinical prediction guides

Motor seizure semiology.
Wu S, Nordli DR
Handb Clin Neurol 2023;196:295-304. doi: 10.1016/B978-0-323-98817-9.00014-4. PMID: 37620075
Relationship Between Epileptic Activity and Developmental Outcome in KCNQ2-Related Epilepsy.
Casas-Alba D, Aguilar A, Alonso I, García MT, Cilio MR, Fons C; BIO-KCNQ2-Spanish Study Group
Pediatr Neurol 2023 Jul;144:11-15. Epub 2023 Mar 9 doi: 10.1016/j.pediatrneurol.2023.03.004. PMID: 37099824
Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
Atypical handedness and its clinicoradiological predictors in children with focal epilepsy.
Sharawat IK, Panda PK, Kasinathan A
Epilepsy Res 2021 Jul;173:106622. Epub 2021 Mar 23 doi: 10.1016/j.eplepsyres.2021.106622. PMID: 33813361
Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis.
D'Antonio F, Pagani G, Familiari A, Khalil A, Sagies TL, Malinger G, Leibovitz Z, Garel C, Moutard ML, Pilu G, Bhide A, Acharya G, Leombroni M, Manzoli L, Papageorghiou A, Prefumo F
Pediatrics 2016 Sep;138(3) doi: 10.1542/peds.2016-0445. PMID: 27581855

Recent systematic reviews

Clinical outcomes of MR-guided laser interstitial thermal therapy corpus callosum ablation in drug-resistant epilepsy: a systematic review and meta-analysis.
Hect JL, Harford E, Maroufi SF, Klem ML, Mansouri A, Abel TJ
J Neurosurg Pediatr 2024 Jan 1;33(1):12-21. Epub 2023 Oct 13 doi: 10.3171/2023.9.PEDS23326. PMID: 37856385
Clinical characterization of non-ketotic hyperglycemia-related seizures: A systematic review and individual participant data meta-analysis.
Licchetta L, Ferri L, Morsillo F, Faustini-Fustini M, Toni F, Pondrelli F, Nonino F, Bisulli F, Tinuper P
Seizure 2023 Mar;106:50-57. Epub 2023 Jan 27 doi: 10.1016/j.seizure.2023.01.018. PMID: 36773573
Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.
Nevitt SJ, Marson AG, Tudur Smith C
Cochrane Database Syst Rev 2018 Oct 24;10(10):CD001904. doi: 10.1002/14651858.CD001904.pub4. PMID: 30353945Free PMC Article
Lacosamide in status epilepticus: Systematic review of current evidence.
Strzelczyk A, Zöllner JP, Willems LM, Jost J, Paule E, Schubert-Bast S, Rosenow F, Bauer S
Epilepsia 2017 Jun;58(6):933-950. Epub 2017 Mar 11 doi: 10.1111/epi.13716. PMID: 28295226
Frontal Lobe Epilepsy: A Primer for Psychiatrists and a Systematic Review of Psychiatric Manifestations.
Gold JA, Sher Y, Maldonado JR
Psychosomatics 2016 Sep-Oct;57(5):445-64. Epub 2016 May 16 doi: 10.1016/j.psym.2016.05.005. PMID: 27494984

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