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Neoplasm of stomach

MedGen UID:
20958
Concept ID:
C0038356
Neoplastic Process
Synonyms: Gastric neoplasm; Neoplasm of the stomach; Stomach Neoplasms
SNOMED CT: Neoplasm of stomach (126824007); Tumor of stomach (126824007)
 
Related genes: PIK3CA, MUTYH, KRAS, IRF1, IL1RN, IL1B, FGFR2, ERBB2, KLF6, CASP10, APC
 
HPO: HP:0006753
Monarch Initiative: MONDO:0021085

Definition

A tumor (abnormal growth of tissue) of the stomach. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Conditions with this feature

Juvenile polyposis syndrome
MedGen UID:
87518
Concept ID:
C0345893
Neoplastic Process
Juvenile polyposis syndrome (JPS) is characterized by predisposition to hamartomatous polyps in the gastrointestinal (GI) tract, specifically in the stomach, small intestine, colon, and rectum. The term "juvenile" refers to the type of polyp rather than to the age of onset of polyps. Most individuals with JPS have some polyps by age 20 years; some may have only four or five polyps over their lifetime, whereas others in the same family may have more than 100. If the polyps are left untreated, they may cause bleeding and anemia. Most juvenile polyps are benign; however, malignant transformation can occur. Risk for GI cancers ranges from 11% to 86%. Most of this increased risk is attributed to colon cancer, but cancers of the stomach, upper GI tract, and pancreas have also been reported. A combined syndrome of JPS and hereditary hemorrhagic telangiectasia (HHT) is present in most individuals with an SMAD4 pathogenic variant.
Colorectal cancer
MedGen UID:
83428
Concept ID:
C0346629
Neoplastic Process
Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.

Professional guidelines

Recent clinical studies

Etiology

Kagamimori S, Matsubara I, Sokejima S, Sekine M, Matsukura T, Nakagawa H, Naruse Y
Ind Health 1998 Jul;36(3):252-7. doi: 10.2486/indhealth.36.252. PMID: 9701904
Banasiewicz T, Marciniak R, Majewski P, Biczysko M, Drews M
Exp Toxicol Pathol 1998 Mar;50(1):83-8. doi: 10.1016/S0940-2993(98)80077-8. PMID: 9570507

Diagnosis

Barut F, Kandemir NO, Gun BD, Ozdamar SO
J Pak Med Assoc 2016 Jul;66(7):905-7. PMID: 27427148
Banasiewicz T, Marciniak R, Majewski P, Biczysko M, Drews M
Exp Toxicol Pathol 1998 Mar;50(1):83-8. doi: 10.1016/S0940-2993(98)80077-8. PMID: 9570507

Therapy

Li MC, Tsai PC, Chen PC, Hsieh CJ, Leon Guo YL, Rogan WJ
Environ Res 2013 Jan;120:71-5. Epub 2012 Sep 29 doi: 10.1016/j.envres.2012.09.003. PMID: 23026800Free PMC Article
Banasiewicz T, Marciniak R, Majewski P, Biczysko M, Drews M
Exp Toxicol Pathol 1998 Mar;50(1):83-8. doi: 10.1016/S0940-2993(98)80077-8. PMID: 9570507

Prognosis

Barut F, Kandemir NO, Gun BD, Ozdamar SO
J Pak Med Assoc 2016 Jul;66(7):905-7. PMID: 27427148
Kagamimori S, Matsubara I, Sokejima S, Sekine M, Matsukura T, Nakagawa H, Naruse Y
Ind Health 1998 Jul;36(3):252-7. doi: 10.2486/indhealth.36.252. PMID: 9701904
Banasiewicz T, Marciniak R, Majewski P, Biczysko M, Drews M
Exp Toxicol Pathol 1998 Mar;50(1):83-8. doi: 10.1016/S0940-2993(98)80077-8. PMID: 9570507

Clinical prediction guides

Barut F, Kandemir NO, Gun BD, Ozdamar SO
J Pak Med Assoc 2016 Jul;66(7):905-7. PMID: 27427148
Banasiewicz T, Marciniak R, Majewski P, Biczysko M, Drews M
Exp Toxicol Pathol 1998 Mar;50(1):83-8. doi: 10.1016/S0940-2993(98)80077-8. PMID: 9570507

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