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Dizygotic twins

MedGen UID:
67400
•Concept ID:
C0220761
•
Finding
Synonym: TWINNING, DIZYGOTIC
 
Gene (location): FSHR (2p16.3)
 
OMIM®: 276400

Definition

The development of two genetically distinct EMBRYOS in a single UTERUS at the same time, from two separate OVA fertilized by two separate SPERMATOZOA. [from MeSH]

Professional guidelines

PubMed

Pharmacogenetics of drug oxidation via cytochrome P450 (CYP) in the populations of Denmark, Faroe Islands and Greenland.
Brosen K
Drug Metab Pers Ther 2015 Sep;30(3):147-63. doi: 10.1515/dmdi-2014-0029. PMID: 25719307
Genetic and environmental influences on testosterone in adolescents: evidence for sex differences.
Harden KP, Kretsch N, Tackett JL, Tucker-Drob EM
Dev Psychobiol 2014 Sep;56(6):1278-89. Epub 2014 Feb 13 doi: 10.1002/dev.21207. PMID: 24523135Free PMC Article
Psoriasis--recent advances in understanding its pathogenesis and treatment.
Krueger G, Ellis CN
J Am Acad Dermatol 2005 Jul;53(1 Suppl 1):S94-100. doi: 10.1016/j.jaad.2005.04.035. PMID: 15968269

Recent clinical studies

Etiology

A review of the biology and classification of human chimeras.
Wenk RE
Transfusion 2018 Aug;58(8):2054-2067. Epub 2018 Aug 28 doi: 10.1111/trf.14791. PMID: 30153329
Lessons learned from twins in autoimmune and chronic inflammatory diseases.
Generali E, Ceribelli A, Stazi MA, Selmi C
J Autoimmun 2017 Sep;83:51-61. Epub 2017 Apr 18 doi: 10.1016/j.jaut.2017.04.005. PMID: 28431796
Transplantation tolerance--a historical introduction.
Brent L
Immunology 2016 Mar;147(3):267-8. Epub 2016 Jan 26 doi: 10.1111/imm.12567. PMID: 26694700Free PMC Article
Twinning.
Hall JG
Lancet 2003 Aug 30;362(9385):735-43. doi: 10.1016/S0140-6736(03)14237-7. PMID: 12957099
Hypodontia in twins.
Markovic M
Swed Dent J Suppl 1982;15:153-62. PMID: 6963769

Diagnosis

Evaluation of Birth Weight and Neurodevelopmental Conditions Among Monozygotic and Dizygotic Twins.
Isaksson J, Ruchkin V, Ljungström T, Bölte S
JAMA Netw Open 2023 Jun 1;6(6):e2321165. doi: 10.1001/jamanetworkopen.2023.21165. PMID: 37389871Free PMC Article
A review of the biology and classification of human chimeras.
Wenk RE
Transfusion 2018 Aug;58(8):2054-2067. Epub 2018 Aug 28 doi: 10.1111/trf.14791. PMID: 30153329
Role of ultrasonography in the management of twin gestation.
Smith J, Treadwell MC, Berman DR
Int J Gynaecol Obstet 2018 Jun;141(3):304-314. Epub 2018 Apr 2 doi: 10.1002/ijgo.12483. PMID: 29536536
Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register.
Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, Werge TM, Nordentoft M, Glenthøj B
Biol Psychiatry 2018 Mar 15;83(6):492-498. Epub 2017 Sep 1 doi: 10.1016/j.biopsych.2017.08.017. PMID: 28987712
Heritability of scoliosis.
Grauers A, Rahman I, Gerdhem P
Eur Spine J 2012 Jun;21(6):1069-74. Epub 2011 Nov 18 doi: 10.1007/s00586-011-2074-1. PMID: 22094388Free PMC Article

Therapy

New insights into the (epi)genetics of twinning.
van Dongen J, Hubers N, Boomsma DI
Hum Reprod 2024 Jan 5;39(1):35-42. doi: 10.1093/humrep/dead131. PMID: 38052159Free PMC Article
Handedness in twins: meta-analyses.
Pfeifer LS, Schmitz J, Papadatou-Pastou M, Peterburs J, Paracchini S, Ocklenburg S
BMC Psychol 2022 Jan 15;10(1):11. doi: 10.1186/s40359-021-00695-3. PMID: 35033205Free PMC Article
Fetal reduction and twins.
Evans MI, Curtis J, Evans SM, Britt DW
Am J Obstet Gynecol MFM 2022 Mar;4(2S):100521. Epub 2021 Oct 23 doi: 10.1016/j.ajogmf.2021.100521. PMID: 34700026
Twins as Participants in Randomized Controlled Trials: A Review of Published Literature.
Sumathipala A, Yelland L, Green D, Shepherd T, Jayaweera K, Ferreira P, Craig JM
Twin Res Hum Genet 2018 Feb;21(1):51-56. Epub 2017 Dec 28 doi: 10.1017/thg.2017.67. PMID: 29282159
Genetic differences in response to alcohol.
Matsushita S, Higuchi S
Handb Clin Neurol 2014;125:617-27. doi: 10.1016/B978-0-444-62619-6.00036-7. PMID: 25307600

Prognosis

Serbian Twin Registry.
Smederevac S, Mitrović D, Sadiković S, Milovanović I, Branovački B, Dinić BM, Nikolašević Ž, Kodžopeljić J, Bugarski Ignjatović V, Semnic M, Vujanić Stankov T, Vučinić N, Oljača M, Pajić D, Stojadinović A, Krstić T, Milutinović A
Twin Res Hum Genet 2019 Dec;22(6):660-666. Epub 2019 Dec 26 doi: 10.1017/thg.2019.114. PMID: 31875804
Lifespans of Twins: Does Zygosity Matter?
Hjelmborg J, Larsen P, Kaprio J, McGue M, Scheike T, Hougaard P, Christensen K
Genes (Basel) 2019 Feb 20;10(2) doi: 10.3390/genes10020166. PMID: 30791679Free PMC Article
Heritability of resting heart rate and association with mortality in middle-aged and elderly twins.
Jensen MT, Wod M, Galatius S, Hjelmborg JB, Jensen GB, Christensen K
Heart 2018 Jan;104(1):30-36. Epub 2017 Jun 21 doi: 10.1136/heartjnl-2016-310986. PMID: 28637897Free PMC Article
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article
Neonatal problems in twins.
McCulloch K
Clin Perinatol 1988 Mar;15(1):141-58. PMID: 3286090

Clinical prediction guides

Evaluation of Birth Weight and Neurodevelopmental Conditions Among Monozygotic and Dizygotic Twins.
Isaksson J, Ruchkin V, Ljungström T, Bölte S
JAMA Netw Open 2023 Jun 1;6(6):e2321165. doi: 10.1001/jamanetworkopen.2023.21165. PMID: 37389871Free PMC Article
Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.
Zeng Y, Suo C, Yao S, Lu D, Larsson H, D'Onofrio BM, Lichtenstein P, Fang F, Valdimarsdóttir UA, Song H
Am J Psychiatry 2023 Apr 1;180(4):294-304. doi: 10.1176/appi.ajp.20220364. PMID: 37002690
Handedness in twins: meta-analyses.
Pfeifer LS, Schmitz J, Papadatou-Pastou M, Peterburs J, Paracchini S, Ocklenburg S
BMC Psychol 2022 Jan 15;10(1):11. doi: 10.1186/s40359-021-00695-3. PMID: 35033205Free PMC Article
Vertical growth in mono-and dizygotic twins: A longitudinal cephalometric cohort study.
Hersberger-Zurfluh MA, Papageorgiou SN, Motro M, Kantarci A, Will LA, Eliades T
Orthod Craniofac Res 2020 May;23(2):192-201. Epub 2019 Dec 4 doi: 10.1111/ocr.12358. PMID: 31746097
Lessons learned from twins in autoimmune and chronic inflammatory diseases.
Generali E, Ceribelli A, Stazi MA, Selmi C
J Autoimmun 2017 Sep;83:51-61. Epub 2017 Apr 18 doi: 10.1016/j.jaut.2017.04.005. PMID: 28431796

Recent systematic reviews

Chorionicity and neurodevelopmental outcomes in twin pregnancy: a systematic review and meta-analysis.
Yan S, Wang Y, Chen Z, Zhang F
J Perinatol 2023 Feb;43(2):133-146. Epub 2022 Nov 4 doi: 10.1038/s41372-022-01534-y. PMID: 36333420
Handedness in twins: meta-analyses.
Pfeifer LS, Schmitz J, Papadatou-Pastou M, Peterburs J, Paracchini S, Ocklenburg S
BMC Psychol 2022 Jan 15;10(1):11. doi: 10.1186/s40359-021-00695-3. PMID: 35033205Free PMC Article
Biliary atresia in twins: a systematic review and meta-analysis.
Xu X, Zhan J
Pediatr Surg Int 2020 Aug;36(8):953-958. Epub 2020 Jun 5 doi: 10.1007/s00383-020-04690-4. PMID: 32504124
Unusual Twinning Resulting in Chimerism: A Systematic Review on Monochorionic Dizygotic Twins.
Peters HE, König TE, Verhoeven MO, Schats R, Mijatovic V, Ket JC, Lambalk CB
Twin Res Hum Genet 2017 Apr;20(2):161-168. Epub 2017 Feb 27 doi: 10.1017/thg.2017.4. PMID: 28236812
Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis.
Cheong-See F, Schuit E, Arroyo-Manzano D, Khalil A, Barrett J, Joseph KS, Asztalos E, Hack K, Lewi L, Lim A, Liem S, Norman JE, Morrison J, Combs CA, Garite TJ, Maurel K, Serra V, Perales A, Rode L, Worda K, Nassar A, Aboulghar M, Rouse D, Thom E, Breathnach F, Nakayama S, Russo FM, Robinson JN, Dodd JM, Newman RB, Bhattacharya S, Tang S, Mol BW, Zamora J, Thilaganathan B, Thangaratinam S; Global Obstetrics Network (GONet) Collaboration
BMJ 2016 Sep 6;354:i4353. doi: 10.1136/bmj.i4353. PMID: 27599496Free PMC Article

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