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Familial hemiplegic migraine

MedGen UID:
87374
Concept ID:
C0338484
Disease or Syndrome
Synonyms: Familial Hemiplegic Migraine; Familial Hemiplegic Migraines; Hemiplegic Migraine, Familial; Hemiplegic-Ophthalmoplegic Migraine
SNOMED CT: Familial hemiplegic migraine (95656000); Hemiplegic-ophthalmoplegic migraine (95656000)
 
Related genes: SCN1A, CACNA1A, ATP1A2
 
Monarch Initiative: MONDO:0000700
OMIM® Phenotypic series: PS141500

Disease characteristics

Excerpted from the GeneReview: Familial Hemiplegic Migraine
Familial hemiplegic migraine (FHM) falls within the category of migraine with aura. In migraine with aura (including FHM) the neurologic symptoms of aura are unequivocally localizable to the cerebral cortex or brain stem and include visual disturbance (most common), sensory loss (e.g., numbness or paresthesias of the face or an extremity), and dysphasia (difficulty with speech). FHM must include motor involvement, such as hemiparesis (weakness of an extremity). Hemiparesis occurs with at least one other symptom during FHM aura. Neurologic deficits with FHM attacks can be prolonged for hours to days and may outlast the associated migrainous headache. FHM is often earlier in onset than typical migraine, frequently beginning in the first or second decade; the frequency of attacks tends to decrease with age. Approximately 40%-50% of families with CACNA1A-FHM have cerebellar signs ranging from nystagmus to progressive, usually late-onset mild ataxia. [from GeneReviews]
Authors:
Joanna C Jen   view full author information

Additional description

From MedlinePlus Genetics
Familial hemiplegic migraine is a form of migraine headache that runs in families. Migraines usually cause intense, throbbing pain in one area of the head, often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. These recurrent headaches typically begin in childhood or adolescence and can be triggered by certain foods, emotional stress, and minor head trauma. Each headache may last from a few hours to a few days.

Unusually severe migraine episodes have been reported in some people with familial hemiplegic migraine. These episodes have included fever, seizures, prolonged weakness, coma, and, rarely, death. Although most people with familial hemiplegic migraine recover completely between episodes, neurological symptoms such as memory loss and problems with attention can last for weeks or months. About 20 percent of people with this condition develop mild but permanent difficulty coordinating movements (ataxia), which may worsen with time, and rapid, involuntary eye movements called nystagmus.

In some types of migraine, including familial hemiplegic migraine, a pattern of neurological symptoms called an aura precedes the headache. The most common symptoms associated with an aura are temporary visual changes such as blind spots (scotomas), flashing lights, zig-zagging lines, and double vision. In people with familial hemiplegic migraine, auras are also characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness. An aura typically develops gradually over a few minutes and lasts about an hour.  https://medlineplus.gov/genetics/condition/familial-hemiplegic-migraine

Professional guidelines

PubMed

Indelicato E, Boesch S
Handb Exp Pharmacol 2023;279:227-248. doi: 10.1007/164_2022_625. PMID: 36592223
Le Roux M, Barth M, Gueden S, Desbordes de Cepoy P, Aeby A, Vilain C, Hirsch E, de Saint Martin A, Portes VD, Lesca G, Riquet A, Chaton L, Villeneuve N, Villard L, Cances C, Valton L, Renaldo F, Vermersch AI, Altuzarra C, Nguyen-Morel MA, Van Gils J, Angelini C, Biraben A, Arnaud L, Riant F, Van Bogaert P
Eur J Paediatr Neurol 2021 Jul;33:75-85. Epub 2021 May 26 doi: 10.1016/j.ejpn.2021.05.010. PMID: 34102571
Russell MB
Expert Rev Neurother 2010 Mar;10(3):381-7. doi: 10.1586/ern.09.127. PMID: 20187861

Curated

Orphanet, Hemiplegic Migraine (HM), 2013

Recent clinical studies

Etiology

Sanchez Del Rio M, Cutrer FM
Handb Clin Neurol 2023;198:71-83. doi: 10.1016/B978-0-12-823356-6.00016-0. PMID: 38043972
Mangano GD, Capizzi MR, Mantuano E, Veneziano L, Santangelo G, Quatrosi G, Nardello R, Raieli V
Headache 2023 Jul-Aug;63(7):889-898. Epub 2023 Jun 16 doi: 10.1111/head.14582. PMID: 37326332
Grangeon L, Lange KS, Waliszewska-Prosół M, Onan D, Marschollek K, Wiels W, Mikulenka P, Farham F, Gollion C, Ducros A; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2023 Feb 20;24(1):12. doi: 10.1186/s10194-023-01547-8. PMID: 36800925Free PMC Article
Ducros A
Rev Neurol (Paris) 2021 Sep;177(7):801-808. Epub 2021 Jul 23 doi: 10.1016/j.neurol.2021.06.002. PMID: 34304862
Anttila V, Wessman M, Kallela M, Palotie A
Handb Clin Neurol 2018;148:493-503. doi: 10.1016/B978-0-444-64076-5.00031-4. PMID: 29478595

Diagnosis

Mangano GD, Capizzi MR, Mantuano E, Veneziano L, Santangelo G, Quatrosi G, Nardello R, Raieli V
Headache 2023 Jul-Aug;63(7):889-898. Epub 2023 Jun 16 doi: 10.1111/head.14582. PMID: 37326332
Nandyala A, Shah T, Ailani J
Curr Neurol Neurosci Rep 2023 Jul;23(7):381-387. Epub 2023 May 29 doi: 10.1007/s11910-023-01277-z. PMID: 37247170
Indelicato E, Boesch S
Handb Exp Pharmacol 2023;279:227-248. doi: 10.1007/164_2022_625. PMID: 36592223
Brunklaus A, Brünger T, Feng T, Fons C, Lehikoinen A, Panagiotakaki E, Vintan MA, Symonds J, Andrew J, Arzimanoglou A, Delima S, Gallois J, Hanrahan D, Lesca G, MacLeod S, Marjanovic D, McTague A, Nuñez-Enamorado N, Perez-Palma E, Scott Perry M, Pysden K, Russ-Hall SJ, Scheffer IE, Sully K, Syrbe S, Vaher U, Velayutham M, Vogt J, Weiss S, Wirrell E, Zuberi SM, Lal D, Møller RS, Mantegazza M, Cestèle S
Brain 2022 Nov 21;145(11):3816-3831. doi: 10.1093/brain/awac210. PMID: 35696452Free PMC Article
Hommersom MP, van Prooije TH, Pennings M, Schouten MI, van Bokhoven H, Kamsteeg EJ, van de Warrenburg BPC
J Neurol 2022 Jun;269(6):3094-3108. Epub 2021 Nov 22 doi: 10.1007/s00415-021-10897-9. PMID: 34806130

Therapy

Gotra P, Bhardwaj N, Ludhiadch A, Singh G, Munshi A
Mol Neurobiol 2021 Aug;58(8):3874-3883. Epub 2021 Apr 15 doi: 10.1007/s12035-021-02386-x. PMID: 33856647
Russell MB
Expert Rev Neurother 2010 Mar;10(3):381-7. doi: 10.1586/ern.09.127. PMID: 20187861
Hansen JM, Thomsen LL, Olesen J, Ashina M
Neurology 2010 Feb 16;74(7):594-600. doi: 10.1212/WNL.0b013e3181cff79d. PMID: 20157162
Gordon N
Brain Dev 1998 Jan;20(1):9-13. doi: 10.1016/s0387-7604(97)00086-7. PMID: 9533553
Glista GG, Mellinger JF, Rooke ED
Mayo Clin Proc 1975 Jun;50(6):307-11. PMID: 1127995

Prognosis

Mangano GD, Capizzi MR, Mantuano E, Veneziano L, Santangelo G, Quatrosi G, Nardello R, Raieli V
Headache 2023 Jul-Aug;63(7):889-898. Epub 2023 Jun 16 doi: 10.1111/head.14582. PMID: 37326332
Lipman AR, Fan X, Shen Y, Chung WK
Clin Genet 2022 Oct;102(4):288-295. Epub 2022 Jun 26 doi: 10.1111/cge.14180. PMID: 35722745Free PMC Article
Vetro A, Nielsen HN, Holm R, Hevner RF, Parrini E, Powis Z, Møller RS, Bellan C, Simonati A, Lesca G, Helbig KL, Palmer EE, Mei D, Ballardini E, Van Haeringen A, Syrbe S, Leuzzi V, Cioni G, Curry CJ, Costain G, Santucci M, Chong K, Mancini GMS, Clayton-Smith J, Bigoni S, Scheffer IE, Dobyns WB, Vilsen B, Guerrini R; ATP1A2/A3-collaborators
Brain 2021 Jun 22;144(5):1435-1450. doi: 10.1093/brain/awab052. PMID: 33880529
Hasırcı Bayır BR, Tutkavul K, Eser M, Baykan B
Seizure 2021 May;88:87-94. Epub 2021 Mar 31 doi: 10.1016/j.seizure.2021.03.028. PMID: 33839563
De Vries B, Haan J, Frants RR, Van den Maagdenberg AM, Ferrari MD
Headache 2006 Jul-Aug;46(7):1059-68. doi: 10.1111/j.1526-4610.2006.00499.x. PMID: 16866710

Clinical prediction guides

Lipman AR, Fan X, Shen Y, Chung WK
Clin Genet 2022 Oct;102(4):288-295. Epub 2022 Jun 26 doi: 10.1111/cge.14180. PMID: 35722745Free PMC Article
Vetro A, Nielsen HN, Holm R, Hevner RF, Parrini E, Powis Z, Møller RS, Bellan C, Simonati A, Lesca G, Helbig KL, Palmer EE, Mei D, Ballardini E, Van Haeringen A, Syrbe S, Leuzzi V, Cioni G, Curry CJ, Costain G, Santucci M, Chong K, Mancini GMS, Clayton-Smith J, Bigoni S, Scheffer IE, Dobyns WB, Vilsen B, Guerrini R; ATP1A2/A3-collaborators
Brain 2021 Jun 22;144(5):1435-1450. doi: 10.1093/brain/awab052. PMID: 33880529
Coppola G, Di Lorenzo C, Parisi V, Lisicki M, Serrao M, Pierelli F
J Headache Pain 2019 Apr 29;20(1):42. doi: 10.1186/s10194-019-0997-9. PMID: 31035929Free PMC Article
Anttila V, Wessman M, Kallela M, Palotie A
Handb Clin Neurol 2018;148:493-503. doi: 10.1016/B978-0-444-64076-5.00031-4. PMID: 29478595
Vincent M, Hadjikhani N
Headache 2007 Jun;47(6):820-33. doi: 10.1111/j.1526-4610.2006.00715.x. PMID: 17578530Free PMC Article

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