U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Progressive spastic paraparesis

MedGen UID:
488935
•Concept ID:
C0747251
•
Sign or Symptom
HPO: HP:0007199

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Progressive spastic paraparesis

Professional guidelines

PubMed

Management of spinal dural arterio-venous fistulas. Report of 12 cases and review of literature.
Rashad S, Abdel-Bary M, Aziz W, Hassan T
Clin Neurol Neurosurg 2014 Oct;125:81-6. Epub 2014 Jul 27 doi: 10.1016/j.clineuro.2014.07.028. PMID: 25108697
Progressive spastic paraparesis: hereditary spastic paraplegia and its relation to primary and amyotrophic lateral sclerosis.
Fink JK
Semin Neurol 2001 Jun;21(2):199-207. doi: 10.1055/s-2001-15265. PMID: 11442328
Differential diagnosis of progressive spastic paraparesis.
Younger DS
Semin Neurol 1993 Dec;13(4):319-21. doi: 10.1055/s-2008-1041141. PMID: 8146480

Recent clinical studies

Etiology

White matter abnormalities in 15 subjects with SPG76.
Alkhalifa A, Chen S, Hasiloglu ZI, Filosto M, Cali E, Houlden H, Sgobbi de Souza P, Alavi A, Goizet C, Stevanin G, Taithe F, Nicita F, Vasco G, Tozza S, Cocozza S, Carboni N, Figus A, Wu J, Basak AN, Brais B, Rouleau G, La Piana R
J Neurol 2023 Dec;270(12):5784-5792. Epub 2023 Aug 14 doi: 10.1007/s00415-023-11918-5. PMID: 37578488
Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Primary Progressive Multiple Sclerosis and Hereditary Spastic Paraplegia Type 4.
Kessler C, Ruschil C, Abdelhak A, Wilke C, Maleska A, Kuhle J, Krumbholz M, Kowarik MC, Schüle R
Int J Mol Sci 2022 Nov 3;23(21) doi: 10.3390/ijms232113466. PMID: 36362248Free PMC Article
Expression of TSLC1 in patients with HAM/TSP.
Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E
J Neurovirol 2020 Jun;26(3):404-414. Epub 2020 Apr 13 doi: 10.1007/s13365-020-00838-z. PMID: 32285300
Acute intermittent porphyria-related leukoencephalopathy.
Kevelam SH, Neeleman RA, Waisfisz Q, Friesema EC, Langendonk JG, van der Knaap MS
Neurology 2016 Sep 20;87(12):1258-65. Epub 2016 Aug 24 doi: 10.1212/WNL.0000000000003129. PMID: 27558376
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412

Diagnosis

GBE1-related disorders: Adult polyglucosan body disease and its neuromuscular phenotypes.
Souza PVS, Badia BML, Farias IB, Pinto WBVR, Oliveira ASB, Akman HO, DiMauro S
J Inherit Metab Dis 2021 May;44(3):534-543. Epub 2020 Nov 13 doi: 10.1002/jimd.12325. PMID: 33141444
Adult-onset spastic paraparesis: an approach to diagnostic work-up.
Zhovtis Ryerson L, Herbert J, Howard J, Kister I
J Neurol Sci 2014 Nov 15;346(1-2):43-50. Epub 2014 Sep 19 doi: 10.1016/j.jns.2014.09.015. PMID: 25263600
Adrenomyeloneuropathy.
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Differential diagnosis of progressive spastic paraparesis.
Younger DS
Semin Neurol 1993 Dec;13(4):319-21. doi: 10.1055/s-2008-1041141. PMID: 8146480
Lathyrism: a neurotoxic disease.
Spencer PS, Schaumburg HH
Neurobehav Toxicol Teratol 1983 Nov-Dec;5(6):625-9. PMID: 6422318

Therapy

Adolescent/Adult-Onset Leukodystrophy with MTHFR Deficiency - A Treatable Cause.
Kumar NH, Mounika KJ, Sundarachary NV
Neurol India 2023 Mar-Apr;71(2):326-328. doi: 10.4103/0028-3886.375409. PMID: 37148062
Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis.
Nozuma S, Kubota R, Jacobson S
J Neurovirol 2020 Oct;26(5):652-663. Epub 2020 Jul 23 doi: 10.1007/s13365-020-00881-w. PMID: 32705480Free PMC Article
Hyperargininemia: 7-month follow-up under sodium benzoate therapy in an Italian child presenting progressive spastic paraparesis, cognitive decline, and novel mutation in ARG1 gene.
Baranello G, Alfei E, Martinelli D, Rizzetto M, Cazzaniga F, Dionisi-Vici C, Gellera C, Castellotti B
Pediatr Neurol 2014 Sep;51(3):430-3. Epub 2014 Jun 4 doi: 10.1016/j.pediatrneurol.2014.05.029. PMID: 24997092
Adrenomyeloneuropathy.
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412

Prognosis

Favorable outcome of hematopoietic stem cell transplantation in late-onset Krabbe disease.
Mitsutake A, Matsukawa T, Iwata A, Ishiura H, Mitsui J, Mori H, Toya T, Honda A, Kurokawa M, Sakai N, Tsuji S, Toda T
Brain Dev 2023 Aug;45(7):408-412. Epub 2023 Apr 18 doi: 10.1016/j.braindev.2023.04.001. PMID: 37080866
Autosomal-dominant early-onset spastic paraparesis with brain calcification due to IFIH1 gain-of-function.
Ruaud L, Rice GI, Cabrol C, Piard J, Rodero M, van Eyk L, Boucher-Brischoux E, de Noordhout AM, Maré R, Scalais E, Pauly F, Debray FG, Dobyns W, Uggenti C, Park JW, Hur S, Livingston JH, Crow YJ, Van Maldergem L
Hum Mutat 2018 Aug;39(8):1076-1080. Epub 2018 Jun 4 doi: 10.1002/humu.23554. PMID: 29782060Free PMC Article
Adrenomyeloneuropathy.
Misra S, Ramesh R, Ramu ChS, Srirangalaxmi G, Radhakrishn H, Vajresware
J Assoc Physicians India 2012 Jul;60:58-61. PMID: 23405547
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
Spastic paraparesis associated with human T-lymphotropic virus type I: a clinical, serological, and genomic study in Iranian-born Mashhadi Jews.
Achiron A, Pinhas-Hamiel O, Doll L, Djaldetti R, Chen A, Ziv I, Avni A, Frankel G, Melamed E, Shohat B
Ann Neurol 1993 Nov;34(5):670-5. doi: 10.1002/ana.410340508. PMID: 8239561

Clinical prediction guides

White matter abnormalities in 15 subjects with SPG76.
Alkhalifa A, Chen S, Hasiloglu ZI, Filosto M, Cali E, Houlden H, Sgobbi de Souza P, Alavi A, Goizet C, Stevanin G, Taithe F, Nicita F, Vasco G, Tozza S, Cocozza S, Carboni N, Figus A, Wu J, Basak AN, Brais B, Rouleau G, La Piana R
J Neurol 2023 Dec;270(12):5784-5792. Epub 2023 Aug 14 doi: 10.1007/s00415-023-11918-5. PMID: 37578488
Expression of TSLC1 in patients with HAM/TSP.
Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E
J Neurovirol 2020 Jun;26(3):404-414. Epub 2020 Apr 13 doi: 10.1007/s13365-020-00838-z. PMID: 32285300
Clinical characteristics of Taiwanese patients with Hereditary spastic paraplegia type 5.
Chou CT, Soong BW, Lin KP, Tsai YS, Jih KY, Liao YC, Lee YC
Ann Clin Transl Neurol 2020 Apr;7(4):486-496. Epub 2020 Mar 22 doi: 10.1002/acn3.51019. PMID: 32202070Free PMC Article
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Contino G, Novelli G
Expert Opin Pharmacother 2006 Oct;7(14):1849-56. doi: 10.1517/14656566.7.14.1849. PMID: 17020412
North American Lyme neuroborreliosis.
Halperin JJ
Scand J Infect Dis Suppl 1991;77:74-80. PMID: 1658921

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...