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Alzheimer Disease with Early Onset

MedGen UID:
155465
Concept ID:
C0750901
Disease or Syndrome
Synonyms: Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia

Professional guidelines

PubMed

Larner AJ
Arch Neurol 2004 May;61(5):801. doi: 10.1001/archneur.61.5.801-a. PMID: 15148163

Recent clinical studies

Etiology

Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM
Nature 2020 Oct;586(7831):735-740. Epub 2020 Sep 2 doi: 10.1038/s41586-020-2681-2. PMID: 32879487Free PMC Article
Villain N, Dubois B
Semin Neurol 2019 Apr;39(2):213-226. Epub 2019 Mar 29 doi: 10.1055/s-0039-1681041. PMID: 30925614
Mendez MF
Continuum (Minneap Minn) 2019 Feb;25(1):34-51. doi: 10.1212/CON.0000000000000687. PMID: 30707186Free PMC Article
Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G, Dubois B, Dufouil C, Ellis KA, van der Flier WM, Glodzik L, van Harten AC, de Leon MJ, McHugh P, Mielke MM, Molinuevo JL, Mosconi L, Osorio RS, Perrotin A, Petersen RC, Rabin LA, Rami L, Reisberg B, Rentz DM, Sachdev PS, de la Sayette V, Saykin AJ, Scheltens P, Shulman MB, Slavin MJ, Sperling RA, Stewart R, Uspenskaya O, Vellas B, Visser PJ, Wagner M; Subjective Cognitive Decline Initiative (SCD-I) Working Group
Alzheimers Dement 2014 Nov;10(6):844-52. Epub 2014 May 3 doi: 10.1016/j.jalz.2014.01.001. PMID: 24798886Free PMC Article
Armstrong RA
Folia Neuropathol 2013;51(3):169-88. doi: 10.5114/fn.2013.37702. PMID: 24114635

Diagnosis

Graff-Radford J, Yong KXX, Apostolova LG, Bouwman FH, Carrillo M, Dickerson BC, Rabinovici GD, Schott JM, Jones DT, Murray ME
Lancet Neurol 2021 Mar;20(3):222-234. doi: 10.1016/S1474-4422(20)30440-3. PMID: 33609479Free PMC Article
Ayodele T, Rogaeva E, Kurup JT, Beecham G, Reitz C
Curr Neurol Neurosci Rep 2021 Jan 19;21(2):4. doi: 10.1007/s11910-020-01090-y. PMID: 33464407Free PMC Article
Mendez MF
Continuum (Minneap Minn) 2019 Feb;25(1):34-51. doi: 10.1212/CON.0000000000000687. PMID: 30707186Free PMC Article
Mendez MF
Neurol Clin 2017 May;35(2):263-281. doi: 10.1016/j.ncl.2017.01.005. PMID: 28410659Free PMC Article
Wu L, Rosa-Neto P, Hsiung GY, Sadovnick AD, Masellis M, Black SE, Jia J, Gauthier S
Can J Neurol Sci 2012 Jul;39(4):436-45. doi: 10.1017/s0317167100013949. PMID: 22728850

Therapy

Fischer CE, Namasivayam A, Crawford-Holland L, Hakobyan N, Schweizer TA, Munoz DG, Pollock BG
Psychiatr Clin North Am 2022 Dec;45(4):691-705. Epub 2022 Oct 14 doi: 10.1016/j.psc.2022.07.001. PMID: 36396273
Megur A, Baltriukienė D, Bukelskienė V, Burokas A
Nutrients 2020 Dec 24;13(1) doi: 10.3390/nu13010037. PMID: 33374235Free PMC Article
Miller DB, O'Callaghan JP
Metabolism 2015 Mar;64(3 Suppl 1):S40-6. Epub 2014 Oct 31 doi: 10.1016/j.metabol.2014.10.030. PMID: 25510818Free PMC Article
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM
Neuron 2007 Feb 1;53(3):337-51. doi: 10.1016/j.neuron.2007.01.010. PMID: 17270732
Blennow K, de Leon MJ, Zetterberg H
Lancet 2006 Jul 29;368(9533):387-403. doi: 10.1016/S0140-6736(06)69113-7. PMID: 16876668

Prognosis

Zhang XX, Tian Y, Wang ZT, Ma YH, Tan L, Yu JT
J Prev Alzheimers Dis 2021;8(3):313-321. doi: 10.14283/jpad.2021.15. PMID: 34101789
Nikolac Perkovic M, Pivac N
Adv Exp Med Biol 2019;1192:27-52. doi: 10.1007/978-981-32-9721-0_3. PMID: 31705489
Mendez MF
Continuum (Minneap Minn) 2019 Feb;25(1):34-51. doi: 10.1212/CON.0000000000000687. PMID: 30707186Free PMC Article
Mendez MF
Neurol Clin 2017 May;35(2):263-281. doi: 10.1016/j.ncl.2017.01.005. PMID: 28410659Free PMC Article
Wu L, Rosa-Neto P, Hsiung GY, Sadovnick AD, Masellis M, Black SE, Jia J, Gauthier S
Can J Neurol Sci 2012 Jul;39(4):436-45. doi: 10.1017/s0317167100013949. PMID: 22728850

Clinical prediction guides

Ray NR, Ayodele T, Jean-Francois M, Baez P, Fernandez V, Bradley J, Crane PK, Dalgard CL, Kuzma A, Nicaretta H, Sims R, Williams J, Cuccaro ML, Pericak-Vance MA, Mayeux R, Wang LS, Schellenberg GD, Cruchaga C, Beecham GW, Reitz C
Alzheimers Dement 2023 Sep;19(9):4187-4195. Epub 2023 Jun 30 doi: 10.1002/alz.13370. PMID: 37390458Free PMC Article
Haoudy S, Jonveaux T, Puisieux S, Epstein J, Hopes L, Maillard L, Aron O, Tyvaert L
J Alzheimers Dis 2022;85(2):615-626. doi: 10.3233/JAD-210681. PMID: 34864663
Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC
Free Radic Biol Med 2018 Jan;114:110-121. Epub 2017 Sep 5 doi: 10.1016/j.freeradbiomed.2017.08.028. PMID: 28882786Free PMC Article
Tellechea P, Pujol N, Esteve-Belloch P, Echeveste B, García-Eulate MR, Arbizu J, Riverol M
Neurologia (Engl Ed) 2018 May;33(4):244-253. Epub 2015 Nov 3 doi: 10.1016/j.nrl.2015.08.002. PMID: 26546285
Paquet D, Kwart D, Chen A, Sproul A, Jacob S, Teo S, Olsen KM, Gregg A, Noggle S, Tessier-Lavigne M
Nature 2016 May 5;533(7601):125-9. Epub 2016 Apr 27 doi: 10.1038/nature17664. PMID: 27120160

Recent systematic reviews

Zhang Y, Ren R, Yang L, Zhang H, Shi Y, Okhravi HR, Vitiello MV, Sanford LD, Tang X
Transl Psychiatry 2022 Apr 1;12(1):136. doi: 10.1038/s41398-022-01897-y. PMID: 35365609Free PMC Article
Jeremic D, Jiménez-Díaz L, Navarro-López JD
Ageing Res Rev 2021 Dec;72:101496. Epub 2021 Oct 21 doi: 10.1016/j.arr.2021.101496. PMID: 34687956
Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A
Mol Psychiatry 2021 Oct;26(10):5481-5503. Epub 2021 Aug 30 doi: 10.1038/s41380-021-01249-0. PMID: 34456336Free PMC Article
Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E
J Sleep Res 2021 Aug;30(4):e13229. Epub 2020 Dec 2 doi: 10.1111/jsr.13229. PMID: 33289311Free PMC Article
Swarbrick S, Wragg N, Ghosh S, Stolzing A
Mol Neurobiol 2019 Sep;56(9):6156-6167. Epub 2019 Feb 8 doi: 10.1007/s12035-019-1500-y. PMID: 30734227Free PMC Article

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