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BLOOD GROUP--LUTHERAN INHIBITOR(INLU)

MedGen UID:
266227
Concept ID:
C1292231
Finding
Synonyms: DOMINANT LU (a-b-) PHENOTYPE; INLU
SNOMED CT: In(Lu) phenotype (115824003); Dominant Lu(a-b-) phenotype (115824003)
 
Gene (location): KLF1 (19p13.13)
 
OMIM®: 111150

Professional guidelines

PubMed

Douketis JD, Spyropoulos AC, Murad MH, Arcelus JI, Dager WE, Dunn AS, Fargo RA, Levy JH, Samama CM, Shah SH, Sherwood MW, Tafur AJ, Tang LV, Moores LK
Chest 2022 Nov;162(5):e207-e243. Epub 2022 Aug 11 doi: 10.1016/j.chest.2022.07.025. PMID: 35964704
Kamada T, Satoh K, Itoh T, Ito M, Iwamoto J, Okimoto T, Kanno T, Sugimoto M, Chiba T, Nomura S, Mieda M, Hiraishi H, Yoshino J, Takagi A, Watanabe S, Koike K
J Gastroenterol 2021 Apr;56(4):303-322. Epub 2021 Feb 23 doi: 10.1007/s00535-021-01769-0. PMID: 33620586Free PMC Article
Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M
Ann Intern Med 2019 Dec 3;171(11):805-822. Epub 2019 Oct 22 doi: 10.7326/M19-1795. PMID: 31634917Free PMC Article

Recent clinical studies

Etiology

Tscharre M, Michelson AD, Gremmel T
J Cardiovasc Pharmacol Ther 2020 May;25(3):191-200. Epub 2020 Jan 21 doi: 10.1177/1074248419899314. PMID: 31960728
Veltkamp R, Purrucker J
Curr Neurol Neurosci Rep 2017 Sep 8;17(10):80. doi: 10.1007/s11910-017-0783-5. PMID: 28887767Free PMC Article
Pabinger I, Fries D, Schöchl H, Streif W, Toller W
Wien Klin Wochenschr 2017 May;129(9-10):303-316. Epub 2017 Apr 21 doi: 10.1007/s00508-017-1194-y. PMID: 28432428Free PMC Article
Hoeper MM, Barst RJ, Bourge RC, Feldman J, Frost AE, Galié N, Gómez-Sánchez MA, Grimminger F, Grünig E, Hassoun PM, Morrell NW, Peacock AJ, Satoh T, Simonneau G, Tapson VF, Torres F, Lawrence D, Quinn DA, Ghofrani HA
Circulation 2013 Mar 12;127(10):1128-38. Epub 2013 Feb 12 doi: 10.1161/CIRCULATIONAHA.112.000765. PMID: 23403476
Rodriguez Merchan EC
Int Orthop 1995;19(4):255-60. doi: 10.1007/BF00185235. PMID: 8557426

Diagnosis

Cuker A, Cataland SR, Coppo P, de la Rubia J, Friedman KD, George JN, Knoebl PN, Kremer Hovinga JA, Lämmle B, Matsumoto M, Pavenski K, Peyvandi F, Sakai K, Sarode R, Thomas MR, Tomiyama Y, Veyradier A, Westwood JP, Scully M
Blood 2021 Apr 8;137(14):1855-1861. doi: 10.1182/blood.2020009150. PMID: 33529333
Schulman S, Gross PL, Ritchie B, Nahirniak S, Lin Y, Lieberman L, Carrier M, Crowther MA, Ghosh I, Lazo-Langner A, Zondag M; Study Investigators
Thromb Haemost 2018 May;118(5):842-851. Epub 2018 Mar 21 doi: 10.1055/s-0038-1636541. PMID: 29564837
Mehta V, Harward SC, Sankey EW, Nayar G, Codd PJ
J Clin Neurosci 2018 Apr;50:7-15. Epub 2018 Feb 7 doi: 10.1016/j.jocn.2018.01.050. PMID: 29428263
Martin K, Beyer-Westendorf J, Davidson BL, Huisman MV, Sandset PM, Moll S
J Thromb Haemost 2016 Jun;14(6):1308-13. Epub 2016 Apr 27 doi: 10.1111/jth.13323. PMID: 27299806Free PMC Article
Kulkarni R, Soucie JM
Semin Thromb Hemost 2011 Oct;37(7):737-44. Epub 2011 Dec 20 doi: 10.1055/s-0031-1297164. PMID: 22187396

Therapy

Li Q, Yakhkind A, Alexandrov AW, Alexandrov AV, Anderson CS, Dowlatshahi D, Frontera JA, Hemphill JC, Ganti L, Kellner C, May C, Morotti A, Parry-Jones A, Sheth KN, Steiner T, Ziai W, Goldstein JN, Mayer SA
Stroke 2024 Feb;55(2):494-505. Epub 2023 Dec 15 doi: 10.1161/STROKEAHA.123.043033. PMID: 38099439
Veltkamp R, Purrucker J
Curr Neurol Neurosci Rep 2017 Sep 8;17(10):80. doi: 10.1007/s11910-017-0783-5. PMID: 28887767Free PMC Article
Roh D, Reznik M, Claassen J
Neurosurg Clin N Am 2017 Apr;28(2):211-217. Epub 2017 Feb 1 doi: 10.1016/j.nec.2016.11.003. PMID: 28325455
Kulkarni R, Soucie JM
Semin Thromb Hemost 2011 Oct;37(7):737-44. Epub 2011 Dec 20 doi: 10.1055/s-0031-1297164. PMID: 22187396
Schulman S, Kearon C; Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis
J Thromb Haemost 2005 Apr;3(4):692-4. doi: 10.1111/j.1538-7836.2005.01204.x. PMID: 15842354

Prognosis

Li Q, Yakhkind A, Alexandrov AW, Alexandrov AV, Anderson CS, Dowlatshahi D, Frontera JA, Hemphill JC, Ganti L, Kellner C, May C, Morotti A, Parry-Jones A, Sheth KN, Steiner T, Ziai W, Goldstein JN, Mayer SA
Stroke 2024 Feb;55(2):494-505. Epub 2023 Dec 15 doi: 10.1161/STROKEAHA.123.043033. PMID: 38099439
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129
McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group
N Engl J Med 2018 Oct 18;379(16):1519-1528. Epub 2018 Sep 16 doi: 10.1056/NEJMoa1803955. PMID: 30221595Free PMC Article
Mehta V, Harward SC, Sankey EW, Nayar G, Codd PJ
J Clin Neurosci 2018 Apr;50:7-15. Epub 2018 Feb 7 doi: 10.1016/j.jocn.2018.01.050. PMID: 29428263
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674

Clinical prediction guides

Harrington J, Piccini JP, Alexander JH, Granger CB, Patel MR
J Am Coll Cardiol 2023 Feb 28;81(8):771-779. doi: 10.1016/j.jacc.2022.11.057. PMID: 36813377
Douxfils J, Adcock DM, Bates SM, Favaloro EJ, Gouin-Thibault I, Guillermo C, Kawai Y, Lindhoff-Last E, Kitchen S, Gosselin RC
Thromb Haemost 2021 Aug;121(8):1008-1020. Epub 2021 May 30 doi: 10.1055/a-1450-8178. [Epub ahead of print] PMID: 33742436
Shi K, Zou M, Jia DM, Shi S, Yang X, Liu Q, Dong JF, Sheth KN, Wang X, Shi FD
Circ Res 2021 Jan 8;128(1):62-75. Epub 2020 Oct 19 doi: 10.1161/CIRCRESAHA.120.317596. PMID: 33070717
Schulman S, Gross PL, Ritchie B, Nahirniak S, Lin Y, Lieberman L, Carrier M, Crowther MA, Ghosh I, Lazo-Langner A, Zondag M; Study Investigators
Thromb Haemost 2018 May;118(5):842-851. Epub 2018 Mar 21 doi: 10.1055/s-0038-1636541. PMID: 29564837
Flaherty ML
Semin Neurol 2010 Nov;30(5):565-72. Epub 2011 Jan 4 doi: 10.1055/s-0030-1268866. PMID: 21207349

Recent systematic reviews

Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, Wong SL, Balaban EP, Flowers CR, Gates LE, Kakkar AK, Tempero MA, Gupta S, Lyman GH, Falanga A
J Clin Oncol 2023 Jun 1;41(16):3063-3071. Epub 2023 Apr 19 doi: 10.1200/JCO.23.00294. PMID: 37075273
Khairani CD, Bejjani A, Piazza G, Jimenez D, Monreal M, Chatterjee S, Pengo V, Woller SC, Cortes-Hernandez J, Connors JM, Kanthi Y, Krumholz HM, Middeldorp S, Falanga A, Cushman M, Goldhaber SZ, Garcia DA, Bikdeli B
J Am Coll Cardiol 2023 Jan 3;81(1):16-30. Epub 2022 Oct 31 doi: 10.1016/j.jacc.2022.10.008. PMID: 36328154Free PMC Article
Kanno T, Yuan Y, Tse F, Howden CW, Moayyedi P, Leontiadis GI
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD005415. doi: 10.1002/14651858.CD005415.pub4. PMID: 34995368Free PMC Article
Stanley AJ, Laine L
BMJ 2019 Mar 25;364:l536. doi: 10.1136/bmj.l536. PMID: 30910853
Sachar H, Vaidya K, Laine L
JAMA Intern Med 2014 Nov;174(11):1755-62. doi: 10.1001/jamainternmed.2014.4056. PMID: 25201154Free PMC Article

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