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Coronary heart disease, susceptibility to, 1

MedGen UID:
375884
•Concept ID:
C1846418
•
Disease or Syndrome
Synonym: Coronary heart disease 1
 
Gene (location): CX3CR1 (3p22.2)
 
Monarch Initiative: MONDO:0011817
OMIM®: 607339

Definition

Any coronary artery disease in which the cause of the disease is a mutation in the CX3CR1 gene. [from MONDO]

Professional guidelines

PubMed

Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association.
Damluji AA, Forman DE, Wang TY, Chikwe J, Kunadian V, Rich MW, Young BA, Page RL 2nd, DeVon HA, Alexander KP; American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Council on Lifestyle and Cardiometabolic Health
Circulation 2023 Jan 17;147(3):e32-e62. Epub 2022 Dec 12 doi: 10.1161/CIR.0000000000001112. PMID: 36503287Free PMC Article
First International Consensus on the diagnosis and management of fibromuscular dysplasia.
Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF
Vasc Med 2019 Apr;24(2):164-189. Epub 2019 Jan 16 doi: 10.1177/1358863X18821816. PMID: 30648921
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article

Recent clinical studies

Etiology

Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.
Luo J, le Cessie S, van Heemst D, Noordam R
J Am Coll Cardiol 2021 Jan 5;77(1):45-54. doi: 10.1016/j.jacc.2020.10.048. PMID: 33413940
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.
Jaiswal S, Natarajan P, Silver AJ, Gibson CJ, Bick AG, Shvartz E, McConkey M, Gupta N, Gabriel S, Ardissino D, Baber U, Mehran R, Fuster V, Danesh J, Frossard P, Saleheen D, Melander O, Sukhova GK, Neuberg D, Libby P, Kathiresan S, Ebert BL
N Engl J Med 2017 Jul 13;377(2):111-121. Epub 2017 Jun 21 doi: 10.1056/NEJMoa1701719. PMID: 28636844Free PMC Article
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality.
Holmes MV, Ala-Korpela M, Smith GD
Nat Rev Cardiol 2017 Oct;14(10):577-590. Epub 2017 Jun 1 doi: 10.1038/nrcardio.2017.78. PMID: 28569269Free PMC Article
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.
Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S
N Engl J Med 2016 Dec 15;375(24):2349-2358. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1605086. PMID: 27959714Free PMC Article
Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction.
Canto JG, Kiefe CI, Rogers WJ, Peterson ED, Frederick PD, French WJ, Gibson CM, Pollack CV Jr, Ornato JP, Zalenski RJ, Penney J, Tiefenbrunn AJ, Greenland P; NRMI Investigators
JAMA 2011 Nov 16;306(19):2120-7. doi: 10.1001/jama.2011.1654. PMID: 22089719Free PMC Article

Diagnosis

Causal Association Between Anemia and Cardiovascular Disease: A 2-Sample Bidirectional Mendelian Randomization Study.
Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y, Lu S, Aledan AKO, Wang Y, Wang Z
J Am Heart Assoc 2023 Jun 20;12(12):e029689. Epub 2023 Jun 10 doi: 10.1161/JAHA.123.029689. PMID: 37301769Free PMC Article
Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study.
Zagkos L, Dib MJ, Pinto R, Gill D, Koskeridis F, Drenos F, Markozannes G, Elliott P, Zuber V, Tsilidis K, Dehghan A, Tzoulaki I
PLoS Med 2022 Dec;19(12):e1004141. Epub 2022 Dec 29 doi: 10.1371/journal.pmed.1004141. PMID: 36580444Free PMC Article
American Heart Association's Life's Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease.
Hasbani NR, Ligthart S, Brown MR, Heath AS, Bebo A, Ashley KE, Boerwinkle E, Morrison AC, Folsom AR, Aguilar D, de Vries PS
Circulation 2022 Mar 15;145(11):808-818. Epub 2022 Jan 31 doi: 10.1161/CIRCULATIONAHA.121.053730. PMID: 35094551Free PMC Article
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.
Richardson TG, Sanderson E, Palmer TM, Ala-Korpela M, Ference BA, Davey Smith G, Holmes MV
PLoS Med 2020 Mar;17(3):e1003062. Epub 2020 Mar 23 doi: 10.1371/journal.pmed.1003062. PMID: 32203549Free PMC Article
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.
Bowden J, Davey Smith G, Haycock PC, Burgess S
Genet Epidemiol 2016 May;40(4):304-14. Epub 2016 Apr 7 doi: 10.1002/gepi.21965. PMID: 27061298Free PMC Article

Therapy

Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.
Luo J, le Cessie S, van Heemst D, Noordam R
J Am Coll Cardiol 2021 Jan 5;77(1):45-54. doi: 10.1016/j.jacc.2020.10.048. PMID: 33413940
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.
Richardson TG, Sanderson E, Palmer TM, Ala-Korpela M, Ference BA, Davey Smith G, Holmes MV
PLoS Med 2020 Mar;17(3):e1003062. Epub 2020 Mar 23 doi: 10.1371/journal.pmed.1003062. PMID: 32203549Free PMC Article
Sarcopenia-related traits and coronary artery disease: a bi-directional Mendelian randomization study.
Liu HM, Zhang Q, Shen WD, Li BY, Lv WQ, Xiao HM, Deng HW
Aging (Albany NY) 2020 Feb 16;12(4):3340-3353. doi: 10.18632/aging.102815. PMID: 32062614Free PMC Article
Sleep Duration and Myocardial Infarction.
Daghlas I, Dashti HS, Lane J, Aragam KG, Rutter MK, Saxena R, Vetter C
J Am Coll Cardiol 2019 Sep 10;74(10):1304-1314. doi: 10.1016/j.jacc.2019.07.022. PMID: 31488267Free PMC Article
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality.
Holmes MV, Ala-Korpela M, Smith GD
Nat Rev Cardiol 2017 Oct;14(10):577-590. Epub 2017 Jun 1 doi: 10.1038/nrcardio.2017.78. PMID: 28569269Free PMC Article

Prognosis

Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.
Luo J, le Cessie S, van Heemst D, Noordam R
J Am Coll Cardiol 2021 Jan 5;77(1):45-54. doi: 10.1016/j.jacc.2020.10.048. PMID: 33413940
Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants.
Fan M, Sun D, Zhou T, Heianza Y, Lv J, Li L, Qi L
Eur Heart J 2020 Mar 14;41(11):1182-1189. doi: 10.1093/eurheartj/ehz849. PMID: 31848595Free PMC Article
Sleep Duration and Myocardial Infarction.
Daghlas I, Dashti HS, Lane J, Aragam KG, Rutter MK, Saxena R, Vetter C
J Am Coll Cardiol 2019 Sep 10;74(10):1304-1314. doi: 10.1016/j.jacc.2019.07.022. PMID: 31488267Free PMC Article
Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study.
Said MA, Verweij N, van der Harst P
JAMA Cardiol 2018 Aug 1;3(8):693-702. doi: 10.1001/jamacardio.2018.1717. PMID: 29955826Free PMC Article
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.
Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S
N Engl J Med 2016 Dec 15;375(24):2349-2358. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1605086. PMID: 27959714Free PMC Article

Clinical prediction guides

Causal Association Between Anemia and Cardiovascular Disease: A 2-Sample Bidirectional Mendelian Randomization Study.
Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y, Lu S, Aledan AKO, Wang Y, Wang Z
J Am Heart Assoc 2023 Jun 20;12(12):e029689. Epub 2023 Jun 10 doi: 10.1161/JAHA.123.029689. PMID: 37301769Free PMC Article
Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study.
Zagkos L, Dib MJ, Pinto R, Gill D, Koskeridis F, Drenos F, Markozannes G, Elliott P, Zuber V, Tsilidis K, Dehghan A, Tzoulaki I
PLoS Med 2022 Dec;19(12):e1004141. Epub 2022 Dec 29 doi: 10.1371/journal.pmed.1004141. PMID: 36580444Free PMC Article
Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.
Luo J, le Cessie S, van Heemst D, Noordam R
J Am Coll Cardiol 2021 Jan 5;77(1):45-54. doi: 10.1016/j.jacc.2020.10.048. PMID: 33413940
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.
Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S
N Engl J Med 2016 Dec 15;375(24):2349-2358. Epub 2016 Nov 13 doi: 10.1056/NEJMoa1605086. PMID: 27959714Free PMC Article
Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction.
Canto JG, Kiefe CI, Rogers WJ, Peterson ED, Frederick PD, French WJ, Gibson CM, Pollack CV Jr, Ornato JP, Zalenski RJ, Penney J, Tiefenbrunn AJ, Greenland P; NRMI Investigators
JAMA 2011 Nov 16;306(19):2120-7. doi: 10.1001/jama.2011.1654. PMID: 22089719Free PMC Article

Recent systematic reviews

Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.
Gill D, Cameron AC, Burgess S, Li X, Doherty DJ, Karhunen V, Abdul-Rahim AH, Taylor-Rowan M, Zuber V, Tsao PS, Klarin D; VA Million Veteran Program, Evangelou E, Elliott P, Damrauer SM, Quinn TJ, Dehghan A, Theodoratou E, Dawson J, Tzoulaki I
Hypertension 2021 Feb;77(2):383-392. Epub 2020 Dec 28 doi: 10.1161/HYPERTENSIONAHA.120.16547. PMID: 33356394Free PMC Article
SCARB1 rs5888 gene polymorphisms in coronary heart disease: A systematic review and a meta-analysis.
Ma R, Zhu X, Yan B
Gene 2018 Dec 15;678:280-287. Epub 2018 Aug 10 doi: 10.1016/j.gene.2018.08.024. PMID: 30103009
Human cytomegalovirus infection and coronary heart disease: a systematic review.
Du Y, Zhang G, Liu Z
Virol J 2018 Feb 6;15(1):31. doi: 10.1186/s12985-018-0937-3. PMID: 29409508Free PMC Article
Association between DNA methylation and coronary heart disease or other atherosclerotic events: A systematic review.
Fernández-Sanlés A, Sayols-Baixeras S, Subirana I, Degano IR, Elosua R
Atherosclerosis 2017 Aug;263:325-333. Epub 2017 May 18 doi: 10.1016/j.atherosclerosis.2017.05.022. PMID: 28577936
TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis.
Lu Y, Boer JM, Barsova RM, Favorova O, Goel A, Müller M, Feskens EJ; PROCARDIS CARDIoGRAM Consortium
BMC Med Genet 2012 May 18;13:39. doi: 10.1186/1471-2350-13-39. PMID: 22607024Free PMC Article

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