U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Colorectal cancer, susceptibility to

MedGen UID:
346821
•Concept ID:
C1858438
•
Finding
Synonyms: COLORECTAL CANCER, SUSCEPTIBILITY TO; Susceptibility to colorectal cancer
 
OMIM®: 168461; 603028; 604373

Professional guidelines

PubMed

The Contribution of MMP-7 Genotypes to Colorectal Cancer Susceptibility in Taiwan.
Yueh TC, Wu CN, Hung YW, Chang WS, Fu CK, Pei JS, Wu MH, Lai YL, Lee YM, Yen ST, Li HT, Tsai CW, Bau DT
Cancer Genomics Proteomics 2018 May-Jun;15(3):207-212. doi: 10.21873/cgp.20079. PMID: 29695403Free PMC Article
When and how to perform genetic testing for inherited colorectal cancer syndromes.
Lynch PM
J Natl Compr Canc Netw 2013 Dec 1;11(12):1577-83. doi: 10.6004/jnccn.2013.0181. PMID: 24335689
SULT1A1 genotype and susceptibility to colorectal cancer.
Lilla C, Risch A, Verla-Tebit E, Hoffmeister M, Brenner H, Chang-Claude J
Int J Cancer 2007 Jan 1;120(1):201-6. doi: 10.1002/ijc.22156. PMID: 17013894

Curated

UK NICE Guideline NG151, Colorectal cancer, 2021

Recent clinical studies

Etiology

The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection.
Patel SG, Karlitz JJ, Yen T, Lieu CH, Boland CR
Lancet Gastroenterol Hepatol 2022 Mar;7(3):262-274. Epub 2022 Jan 26 doi: 10.1016/S2468-1253(21)00426-X. PMID: 35090605
Novel Diagnostic Biomarkers in Colorectal Cancer.
Zygulska AL, Pierzchalski P
Int J Mol Sci 2022 Jan 13;23(2) doi: 10.3390/ijms23020852. PMID: 35055034Free PMC Article
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer.
Zhu G, Pei L, Xia H, Tang Q, Bi F
Mol Cancer 2021 Nov 6;20(1):143. doi: 10.1186/s12943-021-01441-4. PMID: 34742312Free PMC Article
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer.
Mármol I, Sánchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ
Int J Mol Sci 2017 Jan 19;18(1) doi: 10.3390/ijms18010197. PMID: 28106826Free PMC Article
Molecular genetic basis of colorectal cancer susceptibility.
Cunningham C, Dunlop MG
Br J Surg 1996 Mar;83(3):321-9. doi: 10.1002/bjs.1800830309. PMID: 8665182

Diagnosis

The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection.
Patel SG, Karlitz JJ, Yen T, Lieu CH, Boland CR
Lancet Gastroenterol Hepatol 2022 Mar;7(3):262-274. Epub 2022 Jan 26 doi: 10.1016/S2468-1253(21)00426-X. PMID: 35090605
Novel Diagnostic Biomarkers in Colorectal Cancer.
Zygulska AL, Pierzchalski P
Int J Mol Sci 2022 Jan 13;23(2) doi: 10.3390/ijms23020852. PMID: 35055034Free PMC Article
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer.
Zhu G, Pei L, Xia H, Tang Q, Bi F
Mol Cancer 2021 Nov 6;20(1):143. doi: 10.1186/s12943-021-01441-4. PMID: 34742312Free PMC Article
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.
Keum N, Giovannucci E
Nat Rev Gastroenterol Hepatol 2019 Dec;16(12):713-732. Epub 2019 Aug 27 doi: 10.1038/s41575-019-0189-8. PMID: 31455888
Early-onset colorectal cancer in young individuals.
Mauri G, Sartore-Bianchi A, Russo AG, Marsoni S, Bardelli A, Siena S
Mol Oncol 2019 Feb;13(2):109-131. Epub 2018 Dec 22 doi: 10.1002/1878-0261.12417. PMID: 30520562Free PMC Article

Therapy

Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer.
Zhu G, Pei L, Xia H, Tang Q, Bi F
Mol Cancer 2021 Nov 6;20(1):143. doi: 10.1186/s12943-021-01441-4. PMID: 34742312Free PMC Article
Rising incidence of early-onset colorectal cancer - a call to action.
Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y, Ng K, Ogino S
Nat Rev Clin Oncol 2021 Apr;18(4):230-243. Epub 2020 Nov 20 doi: 10.1038/s41571-020-00445-1. PMID: 33219329Free PMC Article
Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer.
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.
Keum N, Giovannucci E
Nat Rev Gastroenterol Hepatol 2019 Dec;16(12):713-732. Epub 2019 Aug 27 doi: 10.1038/s41575-019-0189-8. PMID: 31455888
Recent advances in Lynch syndrome.
Biller LH, Syngal S, Yurgelun MB
Fam Cancer 2019 Apr;18(2):211-219. doi: 10.1007/s10689-018-00117-1. PMID: 30627969Free PMC Article

Prognosis

The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection.
Patel SG, Karlitz JJ, Yen T, Lieu CH, Boland CR
Lancet Gastroenterol Hepatol 2022 Mar;7(3):262-274. Epub 2022 Jan 26 doi: 10.1016/S2468-1253(21)00426-X. PMID: 35090605
Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes.
Baidoun F, Elshiwy K, Elkeraie Y, Merjaneh Z, Khoudari G, Sarmini MT, Gad M, Al-Husseini M, Saad A
Curr Drug Targets 2021;22(9):998-1009. doi: 10.2174/1389450121999201117115717. PMID: 33208072
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.
Keum N, Giovannucci E
Nat Rev Gastroenterol Hepatol 2019 Dec;16(12):713-732. Epub 2019 Aug 27 doi: 10.1038/s41575-019-0189-8. PMID: 31455888
Early-onset colorectal cancer in young individuals.
Mauri G, Sartore-Bianchi A, Russo AG, Marsoni S, Bardelli A, Siena S
Mol Oncol 2019 Feb;13(2):109-131. Epub 2018 Dec 22 doi: 10.1002/1878-0261.12417. PMID: 30520562Free PMC Article
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer.
Mármol I, Sánchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ
Int J Mol Sci 2017 Jan 19;18(1) doi: 10.3390/ijms18010197. PMID: 28106826Free PMC Article

Clinical prediction guides

The aging-related risk signature in colorectal cancer.
Yue T, Chen S, Zhu J, Guo S, Huang Z, Wang P, Zuo S, Liu Y
Aging (Albany NY) 2021 Feb 26;13(5):7330-7349. doi: 10.18632/aging.202589. PMID: 33658390Free PMC Article
Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer.
Lin A, Zhang J, Luo P
Front Immunol 2020;11:2039. Epub 2020 Aug 12 doi: 10.3389/fimmu.2020.02039. PMID: 32903444Free PMC Article
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer.
Mármol I, Sánchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ
Int J Mol Sci 2017 Jan 19;18(1) doi: 10.3390/ijms18010197. PMID: 28106826Free PMC Article
Colorectal cancer: from prevention to personalized medicine.
Binefa G, Rodríguez-Moranta F, Teule A, Medina-Hayas M
World J Gastroenterol 2014 Jun 14;20(22):6786-808. doi: 10.3748/wjg.v20.i22.6786. PMID: 24944469Free PMC Article
Hereditary and familial colon cancer.
Jasperson KW, Tuohy TM, Neklason DW, Burt RW
Gastroenterology 2010 Jun;138(6):2044-58. doi: 10.1053/j.gastro.2010.01.054. PMID: 20420945Free PMC Article

Recent systematic reviews

Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis.
Sharzehan MAK, Sito H, Abdullah N, Alexiou A, Papadakis M, Jamal R, Tan SC
Sci Rep 2022 Nov 23;12(1):20149. doi: 10.1038/s41598-022-24398-w. PMID: 36418904Free PMC Article
Microwave Ablation, Radiofrequency Ablation, Irreversible Electroporation, and Stereotactic Ablative Body Radiotherapy for Intermediate Size (3-5 cm) Unresectable Colorectal Liver Metastases: a Systematic Review and Meta-analysis.
Nieuwenhuizen S, Dijkstra M, Puijk RS, Geboers B, Ruarus AH, Schouten EA, Nielsen K, de Vries JJJ, Bruynzeel AME, Scheffer HJ, van den Tol MP, Haasbeek CJA, Meijerink MR
Curr Oncol Rep 2022 Jun;24(6):793-808. Epub 2022 Mar 17 doi: 10.1007/s11912-022-01248-6. PMID: 35298796Free PMC Article
BRCA1 and BRCA2 Gene Mutations and Colorectal Cancer Risk: Systematic Review and Meta-analysis.
Oh M, McBride A, Yun S, Bhattacharjee S, Slack M, Martin JR, Jeter J, Abraham I
J Natl Cancer Inst 2018 Nov 1;110(11):1178-1189. doi: 10.1093/jnci/djy148. PMID: 30380096
Causal inference in obesity research.
Franks PW, Atabaki-Pasdar N
J Intern Med 2017 Mar;281(3):222-232. Epub 2016 Dec 8 doi: 10.1111/joim.12577. PMID: 27933671
Risk of colorectal cancer with hysterectomy and oophorectomy: A systematic review and meta-analysis.
Luo G, Zhang Y, Wang L, Huang Y, Yu Q, Guo P, Li K
Int J Surg 2016 Oct;34:88-95. Epub 2016 Aug 26 doi: 10.1016/j.ijsu.2016.08.518. PMID: 27568653

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG151, Colorectal cancer, 2021

    Consumer resources

    Reviews

    Related information

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...