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Asthma, nasal polyps, and aspirin intolerance

MedGen UID:
347198
Concept ID:
C1859648
Disease or Syndrome
Synonym: ASA TRIAD
 
Genes (locations): PTGER2 (14q22.1); TBX21 (17q21.32)
 
Monarch Initiative: MONDO:0008834
OMIM®: 208550

Clinical features

From HPO
Bronchoconstriction
MedGen UID:
36266
Concept ID:
C0079043
Organ or Tissue Function
Tightening of smooth muscle surrounding the bronchi and bronchioles with consequent wheezing and shortness of breath.
Asthma
MedGen UID:
2109
Concept ID:
C0004096
Disease or Syndrome
Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.
Aspirin-induced asthma
MedGen UID:
230819
Concept ID:
C1319853
Disease or Syndrome
A type of asthma in which aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygen-ase 1 (COX-1) exacerbate bronchoconstriction.
Nasal polyposis
MedGen UID:
6524
Concept ID:
C0027430
Anatomical Abnormality
Polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are freely movable and nontender overgrowths of the mucosa that frequently accompany allergic rhinitis.

Recent clinical studies

Etiology

Candar T, Baklaci D, Kuzucu I, Kayabasi S
Acta Biochim Pol 2020 Aug 31;67(3):367-371. doi: 10.18388/abp.2020_5204. PMID: 32865947
Kim SH, Choi H, Yoon MG, Ye YM, Park HS
Ann Allergy Asthma Immunol 2015 Mar;114(3):208-13. Epub 2015 Jan 13 doi: 10.1016/j.anai.2014.12.003. PMID: 25592153
Mewes T, Riechelmann H, Klimek L
Allergy 1996 Jul;51(7):506-10. doi: 10.1111/j.1398-9995.1996.tb04657.x. PMID: 8863928

Diagnosis

Candar T, Baklaci D, Kuzucu I, Kayabasi S
Acta Biochim Pol 2020 Aug 31;67(3):367-371. doi: 10.18388/abp.2020_5204. PMID: 32865947
Mewes T, Riechelmann H, Klimek L
Allergy 1996 Jul;51(7):506-10. doi: 10.1111/j.1398-9995.1996.tb04657.x. PMID: 8863928

Therapy

Mewes T, Riechelmann H, Klimek L
Allergy 1996 Jul;51(7):506-10. doi: 10.1111/j.1398-9995.1996.tb04657.x. PMID: 8863928

Clinical prediction guides

Candar T, Baklaci D, Kuzucu I, Kayabasi S
Acta Biochim Pol 2020 Aug 31;67(3):367-371. doi: 10.18388/abp.2020_5204. PMID: 32865947
El Fakiri MM, Lakhdar Y, Raji A
BMJ Case Rep 2019 Mar 31;12(3) doi: 10.1136/bcr-2018-229021. PMID: 30936362Free PMC Article

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