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Plasma fibronectin deficiency

MedGen UID:
436433
•Concept ID:
C2675436
•
Finding
Synonym: PLASMA FIBRONECTIN DEFICIENCY
 
Monarch Initiative: MONDO:0013575
OMIM®: 614101

Clinical features

From HPO
Reduced circulating fibronectin level
MedGen UID:
1702486
•Concept ID:
C5139361
•
Finding
A reduction below the normal concentration of fibronectin the the blood circulation.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Cryoprecipitate: an outmoded treatment?
Yang L, Stanworth S, Baglin T
Transfus Med 2012 Oct;22(5):315-20. doi: 10.1111/j.1365-3148.2012.01181.x. PMID: 22994448

Recent clinical studies

Etiology

Plasma fibronectin.
Saba TM
Br J Hosp Med 1986 Nov;36(5):364, 366. PMID: 3790862
Lung vascular permeability after reversal of fibronectin deficiency in septic sheep. Correlation with patient studies.
Saba TM, Niehaus GD, Scovill WA, Blumenstock FA, Newell JC, Holman J Jr, Powers SR Jr
Ann Surg 1983 Nov;198(5):654-62. doi: 10.1097/00000658-198311000-00016. PMID: 6416192Free PMC Article

Therapy

Plasma fibronectin levels during cardiopulmonary bypass.
Charash WE, Foster ED, Saba TM, Dayton C, Cho E
J Appl Physiol (1985) 1990 Nov;69(5):1644-50. doi: 10.1152/jappl.1990.69.5.1644. PMID: 2272956
Reversal of opsonic deficiency in surgical, trauma, and burn patients by infusion of purified human plasma fibronectin. Correlation with experimental observations.
Saba TM, Blumenstock FA, Shah DM, Landaburu RH, Hrinda ME, Deno DC, Holman JM Jr, Cho E, Dayton C, Cardarelli PM
Am J Med 1986 Feb;80(2):229-40. doi: 10.1016/0002-9343(86)90014-8. PMID: 3946437
Reversal of fibronectin and opsonic deficiency in patients. A controlled study.
Saba TM, Blumenstock FA, Shah DM, Kaplan JE, Cho E, Scovill W, Stratton H, Newell J, Gottlieb M, Sedransk N
Ann Surg 1984 Jan;199(1):87-96. doi: 10.1097/00000658-198401000-00015. PMID: 6362585Free PMC Article
Lung vascular permeability after reversal of fibronectin deficiency in septic sheep. Correlation with patient studies.
Saba TM, Niehaus GD, Scovill WA, Blumenstock FA, Newell JC, Holman J Jr, Powers SR Jr
Ann Surg 1983 Nov;198(5):654-62. doi: 10.1097/00000658-198311000-00016. PMID: 6416192Free PMC Article
Reversal of plasma fibronectin deficiency in septic-injured patients by cryoprecipitate infusion.
Saba TM
Prog Clin Biol Res 1982;108:129-50. PMID: 6757957

Prognosis

Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation.
Rohwedder I, Montanez E, Beckmann K, Bengtsson E, Dunér P, Nilsson J, Soehnlein O, Fässler R
EMBO Mol Med 2012 Jul;4(7):564-76. Epub 2012 Apr 19 doi: 10.1002/emmm.201200237. PMID: 22514136Free PMC Article

Clinical prediction guides

Reversal of opsonic deficiency in surgical, trauma, and burn patients by infusion of purified human plasma fibronectin. Correlation with experimental observations.
Saba TM, Blumenstock FA, Shah DM, Landaburu RH, Hrinda ME, Deno DC, Holman JM Jr, Cho E, Dayton C, Cardarelli PM
Am J Med 1986 Feb;80(2):229-40. doi: 10.1016/0002-9343(86)90014-8. PMID: 3946437
Plasma fibronectin.
Saba TM
Br J Hosp Med 1986 Nov;36(5):364, 366. PMID: 3790862
Reversal of fibronectin and opsonic deficiency in patients. A controlled study.
Saba TM, Blumenstock FA, Shah DM, Kaplan JE, Cho E, Scovill W, Stratton H, Newell J, Gottlieb M, Sedransk N
Ann Surg 1984 Jan;199(1):87-96. doi: 10.1097/00000658-198401000-00015. PMID: 6362585Free PMC Article

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