U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Microvascular complications of diabetes, susceptibility to, 1(MVCD1)

MedGen UID:
382957
•Concept ID:
C2676832
•
Finding
Synonym: Microvascular complications of diabetes 1
 
Gene (location): VEGFA (6p21.1)
 
Monarch Initiative: MONDO:0011386
OMIM®: 603933

Definition

Any microvascular complications of diabetes, susceptibility in which the cause of the disease is a mutation in the VEGFA gene. [from MONDO]

Professional guidelines

PubMed

The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935
Nitrosative injury and antioxidant therapy in the management of diabetic neuropathy.
Cowell RM, Russell JW
J Investig Med 2004 Jan;52(1):33-44. doi: 10.1136/jim-52-01-24. PMID: 14989368

Recent clinical studies

Etiology

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Genetics of diabetes-associated microvascular complications.
Lyssenko V, Vaag A
Diabetologia 2023 Sep;66(9):1601-1613. Epub 2023 Jul 14 doi: 10.1007/s00125-023-05964-x. PMID: 37452207Free PMC Article
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy.
Dewanjee S, Vallamkondu J, Kalra RS, John A, Reddy PH, Kandimalla R
Ageing Res Rev 2021 Jul;68:101338. Epub 2021 Apr 7 doi: 10.1016/j.arr.2021.101338. PMID: 33838320
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article

Diagnosis

Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.
Mansour A, Mousa M, Abdelmannan D, Tay G, Hassoun A, Alsafar H
Front Endocrinol (Lausanne) 2023;14:1143067. Epub 2023 Mar 23 doi: 10.3389/fendo.2023.1143067. PMID: 37033211Free PMC Article
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Diabetic nephropathy--emerging epigenetic mechanisms.
Kato M, Natarajan R
Nat Rev Nephrol 2014 Sep;10(9):517-30. Epub 2014 Jul 8 doi: 10.1038/nrneph.2014.116. PMID: 25003613Free PMC Article
MicroRNAs and diabetic complications.
Natarajan R, Putta S, Kato M
J Cardiovasc Transl Res 2012 Aug;5(4):413-22. Epub 2012 May 3 doi: 10.1007/s12265-012-9368-5. PMID: 22552970Free PMC Article

Therapy

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes.
Chen R, Ovbiagele B, Feng W
Am J Med Sci 2016 Apr;351(4):380-6. doi: 10.1016/j.amjms.2016.01.011. PMID: 27079344Free PMC Article
Diabetes mellitus: novel insights, analysis and interpretation of pathophysiology and complications management with imidazole-containing peptidomimetic antioxidants.
Babizhayev MA, Lankin VZ, Savel'Yeva EL, Deyev AI, Yegorov YE
Recent Pat Drug Deliv Formul 2013 Dec;7(3):216-56. doi: 10.2174/1872211307666131117121058. PMID: 24236935
Haptoglobin: basic and clinical aspects.
Levy AP, Asleh R, Blum S, Levy NS, Miller-Lotan R, Kalet-Litman S, Anbinder Y, Lache O, Nakhoul FM, Asaf R, Farbstein D, Pollak M, Soloveichik YZ, Strauss M, Alshiek J, Livshits A, Schwartz A, Awad H, Jad K, Goldenstein H
Antioxid Redox Signal 2010 Feb;12(2):293-304. doi: 10.1089/ars.2009.2793. PMID: 19659435

Prognosis

Relationship between circulating metabolites and diabetic retinopathy: a two-sample Mendelian randomization analysis.
Ma L, Dong Y, Li Z, Meng J, Zhao B, Wang Q
Sci Rep 2024 Feb 29;14(1):4964. doi: 10.1038/s41598-024-55704-3. PMID: 38424453Free PMC Article
Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Importance of Identifying Novel Biomarkers of Microvascular Damage in Type 1 Diabetes.
Marcovecchio ML
Mol Diagn Ther 2020 Oct;24(5):507-515. doi: 10.1007/s40291-020-00483-6. PMID: 32613289
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.
Dalan R, Liuh Ling G
Eur J Prev Cardiol 2018 Sep;25(14):1502-1519. Epub 2018 May 25 doi: 10.1177/2047487318776829. PMID: 29799294
The impact of diabetes on corneal nerve morphology and ocular surface integrity.
Markoulli M, Flanagan J, Tummanapalli SS, Wu J, Willcox M
Ocul Surf 2018 Jan;16(1):45-57. Epub 2017 Nov 4 doi: 10.1016/j.jtos.2017.10.006. PMID: 29113918

Clinical prediction guides

Genetics and epigenetics of diabetes and its complications in India.
Priyadarshini A, Madan R, Das S
Hum Genet 2024 Jan;143(1):1-17. Epub 2023 Nov 24 doi: 10.1007/s00439-023-02616-3. PMID: 37999799
Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1(I249/M280)-expressing retina.
Church KA, Rodriguez D, Mendiola AS, Vanegas D, Gutierrez IL, Tamayo I, Amadu A, Velazquez P, Cardona SM, Gyoneva S, Cotleur AC, Ransohoff RM, Kaur T, Cardona AE
Front Immunol 2023;14:1130735. Epub 2023 Mar 22 doi: 10.3389/fimmu.2023.1130735. PMID: 37033925Free PMC Article
The impact of diabetes on corneal nerve morphology and ocular surface integrity.
Markoulli M, Flanagan J, Tummanapalli SS, Wu J, Willcox M
Ocul Surf 2018 Jan;16(1):45-57. Epub 2017 Nov 4 doi: 10.1016/j.jtos.2017.10.006. PMID: 29113918
Diabetic Microvascular Complications: Novel Risk Factors, Biomarkers, and Risk Prediction Models.
McKay GJ, Teo BW, Zheng YF, Sambamoorthi U, Sabanayagam C
J Diabetes Res 2016;2016:2172106. Epub 2015 Dec 8 doi: 10.1155/2016/2172106. PMID: 26779541Free PMC Article
The role of epigenetics in the pathology of diabetic complications.
Villeneuve LM, Natarajan R
Am J Physiol Renal Physiol 2010 Jul;299(1):F14-25. Epub 2010 May 12 doi: 10.1152/ajprenal.00200.2010. PMID: 20462972Free PMC Article

Recent systematic reviews

(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K
Cochrane Database Syst Rev 2020 Nov 9;11(11):CD005613. doi: 10.1002/14651858.CD005613.pub4. PMID: 33166419Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...