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Tolbutamide response

MedGen UID:: 865155
•Concept ID:: C4016718
•: Finding

Synonym:	Tolbutamide poor metabolizer
Drug:	Tolbutamide MedGen UID: 21577 •Concept ID: C0040374 • Pharmacologic Substance A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to cause adverse effects, such as jaundice. This agent is rapidly metabolized by CYPC29. [from NCI] Tolbutamide

Gene (location): Gene(s) directly associated with this condition or phenotype.	G6PD (Xq28)

OMIM®:	601130

Professional guidelines

PubMed

Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method.

Gao J, Zhang Y, Lei X, Xu Y, Sun Z, Wang X
Toxicol In Vitro 2022 Mar;79:105281. Epub 2021 Nov 26 doi: 10.1016/j.tiv.2021.105281. PMID: 34843882

Genetic risk factors for type 2 diabetes mellitus and response to sulfonylurea treatment.

Swen JJ, Guchelaar HJ, Baak-Pablo RF, Assendelft WJ, Wessels JA
Pharmacogenet Genomics 2011 Aug;21(8):461-8. doi: 10.1097/FPC.0b013e3283478173. PMID: 21633322

Metformin: an antihyperglycemic agent for treatment of type II diabetes.

Melchior WR, Jaber LA
Ann Pharmacother 1996 Feb;30(2):158-64. doi: 10.1177/106002809603000210. PMID: 8835050

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Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

Recent clinical studies

Diagnosis

Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.

Pearson ER, Badman MK, Lockwood CR, Clark PM, Ellard S, Bingham C, Hattersley AT
Diabetes Care 2004 May;27(5):1102-7. doi: 10.2337/diacare.27.5.1102. PMID: 15111528

Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.

Lippiat JD, Albinson SL, Ashcroft FM
Diabetes 2002 Dec;51 Suppl 3:S377-80. doi: 10.2337/diabetes.51.2007.s377. PMID: 12475778

Diabetes mellitus--current criteria for laboratory diagnosis.

Alexander RW
Calif Med 1969 Feb;110(2):107-13. PMID: 5805334 Free PMC Article

The intravenous tolbutamide response in the diagnosis of diabetes.

Walker RL
Med J Aust 1968 Jul 27;2(4):164-6. doi: 10.5694/j.1326-5377.1968.tb29380.x. PMID: 5670885

The intravenous tolbutamide response test in the diagnosis of mild diabetes.

UNGER RH, MADISON LL
Ann N Y Acad Sci 1959 Mar 30;74(3):667-71. doi: 10.1111/j.1749-6632.1959.tb39593.x. PMID: 13637606

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Therapy

Effect of tolbutamide on plasma catecholamine in insulin dependent diabetics.

Sato T, Miura Y, Saito T, Ito M, Kokubun M, Sakuma H, Adachi M, Yoshinaga K
Tohoku J Exp Med 1979 Jan;127(1):97-8. doi: 10.1620/tjem.127.97. PMID: 760255

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Clinical prediction guides

Effect of tolbutamide on plasma catecholamine in insulin dependent diabetics.

Sato T, Miura Y, Saito T, Ito M, Kokubun M, Sakuma H, Adachi M, Yoshinaga K
Tohoku J Exp Med 1979 Jan;127(1):97-8. doi: 10.1620/tjem.127.97. PMID: 760255

The intravenous tolbutamide response test. Initial observations.

WHITEHOUSE FW, LOWRIE WL
J Mich State Med Soc 1960 Oct;59:1540-42. PMID: 13784885

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MedGen

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Tolbutamide response

Professional guidelines

PubMed

Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

Recent clinical studies

Diagnosis

Therapy

Clinical prediction guides

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