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Desipramine response

MedGen UID:
851737
•Concept ID:
CN233052
•
Sign or Symptom
Drug:
desipramine
MedGen UID:
8339
•Concept ID:
C0011685
•
Pharmacologic Substance
An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage. [from NCI]
desipramine
 
Gene (location): CYP2D6 (22q13.2)

Professional guidelines

PubMed

Evaluation and Treatment of Vulvodynia: State of the Science.
Schlaeger JM, Glayzer JE, Villegas-Downs M, Li H, Glayzer EJ, He Y, Takayama M, Yajima H, Takakura N, Kobak WH, McFarlin BL
J Midwifery Womens Health 2023 Jan;68(1):9-34. Epub 2022 Dec 19 doi: 10.1111/jmwh.13456. PMID: 36533637Free PMC Article
Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis.
Zhou X, Teng T, Zhang Y, Del Giovane C, Furukawa TA, Weisz JR, Li X, Cuijpers P, Coghill D, Xiang Y, Hetrick SE, Leucht S, Qin M, Barth J, Ravindran AV, Yang L, Curry J, Fan L, Silva SG, Cipriani A, Xie P
Lancet Psychiatry 2020 Jul;7(7):581-601. doi: 10.1016/S2215-0366(20)30137-1. PMID: 32563306Free PMC Article
Dose equivalents of antidepressants: Evidence-based recommendations from randomized controlled trials.
Hayasaka Y, Purgato M, Magni LR, Ogawa Y, Takeshima N, Cipriani A, Barbui C, Leucht S, Furukawa TA
J Affect Disord 2015 Jul 15;180:179-84. Epub 2015 Mar 31 doi: 10.1016/j.jad.2015.03.021. PMID: 25911132

Suggested Reading

PubMed

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC
Clin Pharmacol Ther 2017 Jul;102(1):37-44. Epub 2017 Feb 13 doi: 10.1002/cpt.597. PMID: 27997040Free PMC Article

Recent clinical studies

Etiology

Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence.
Sofuoglu M, Gonzalez G, Poling J, Kosten TR
Am J Drug Alcohol Abuse 2003;29(4):713-27. doi: 10.1081/ada-120026256. PMID: 14713135
Desipramine versus phenelzine in recurrent unipolar depression: clinical characteristics and treatment response.
Swann AC, Bowden CL, Rush AJ, Rhoades H, Rose R, Kobes R
J Clin Psychopharmacol 1997 Apr;17(2):78-83. doi: 10.1097/00004714-199704000-00002. PMID: 10950467
Cardiac beta-adrenergic sensitivity in depression: relation with endogenous subtype and desipramine response.
Bertschy G, Vandel S, Puech A, Vandel B, Sandoz M, Allers G
Neuropsychobiology 1989;21(4):177-81. doi: 10.1159/000118573. PMID: 2561009

Diagnosis

Cardiac beta-adrenergic sensitivity in depression: relation with endogenous subtype and desipramine response.
Bertschy G, Vandel S, Puech A, Vandel B, Sandoz M, Allers G
Neuropsychobiology 1989;21(4):177-81. doi: 10.1159/000118573. PMID: 2561009

Therapy

Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence.
Sofuoglu M, Gonzalez G, Poling J, Kosten TR
Am J Drug Alcohol Abuse 2003;29(4):713-27. doi: 10.1081/ada-120026256. PMID: 14713135
Desipramine versus phenelzine in recurrent unipolar depression: clinical characteristics and treatment response.
Swann AC, Bowden CL, Rush AJ, Rhoades H, Rose R, Kobes R
J Clin Psychopharmacol 1997 Apr;17(2):78-83. doi: 10.1097/00004714-199704000-00002. PMID: 10950467
Changes in thyroid hormone levels associated with desipramine response in adolescent depression.
Sokolov ST, Kutcher SP, Joffe RT
Prog Neuropsychopharmacol Biol Psychiatry 1996 Aug;20(6):1053-63. doi: 10.1016/0278-5846(96)00083-8. PMID: 8888110
Temperament predicts clomipramine and desipramine response in major depression.
Joyce PR, Mulder RT, Cloninger CR
J Affect Disord 1994 Jan;30(1):35-46. doi: 10.1016/0165-0327(94)90149-x. PMID: 8151047
Dextroamphetamine and dexamethasone suppression test prediction of desipramine response.
Faber R, Williams K, Prescott D, Bassett D, Bixler G
Biol Psychiatry 1989 Mar 1;25(5):657-60. doi: 10.1016/0006-3223(89)90232-1. PMID: 2920200

Prognosis

Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence.
Sofuoglu M, Gonzalez G, Poling J, Kosten TR
Am J Drug Alcohol Abuse 2003;29(4):713-27. doi: 10.1081/ada-120026256. PMID: 14713135
Desipramine versus phenelzine in recurrent unipolar depression: clinical characteristics and treatment response.
Swann AC, Bowden CL, Rush AJ, Rhoades H, Rose R, Kobes R
J Clin Psychopharmacol 1997 Apr;17(2):78-83. doi: 10.1097/00004714-199704000-00002. PMID: 10950467
Exploring the TPQ as a possible predictor of antidepressant response to nefazodone in a large multi-site study.
Nelson E, Cloninger CR
J Affect Disord 1997 Jul;44(2-3):197-200. doi: 10.1016/s0165-0327(97)00047-5. PMID: 9241580
Temperament predicts clomipramine and desipramine response in major depression.
Joyce PR, Mulder RT, Cloninger CR
J Affect Disord 1994 Jan;30(1):35-46. doi: 10.1016/0165-0327(94)90149-x. PMID: 8151047
Dextroamphetamine and dexamethasone suppression test prediction of desipramine response.
Faber R, Williams K, Prescott D, Bassett D, Bixler G
Biol Psychiatry 1989 Mar 1;25(5):657-60. doi: 10.1016/0006-3223(89)90232-1. PMID: 2920200

Clinical prediction guides

Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence.
Sofuoglu M, Gonzalez G, Poling J, Kosten TR
Am J Drug Alcohol Abuse 2003;29(4):713-27. doi: 10.1081/ada-120026256. PMID: 14713135
Desipramine versus phenelzine in recurrent unipolar depression: clinical characteristics and treatment response.
Swann AC, Bowden CL, Rush AJ, Rhoades H, Rose R, Kobes R
J Clin Psychopharmacol 1997 Apr;17(2):78-83. doi: 10.1097/00004714-199704000-00002. PMID: 10950467
Changes in thyroid hormone levels associated with desipramine response in adolescent depression.
Sokolov ST, Kutcher SP, Joffe RT
Prog Neuropsychopharmacol Biol Psychiatry 1996 Aug;20(6):1053-63. doi: 10.1016/0278-5846(96)00083-8. PMID: 8888110
Temperament predicts clomipramine and desipramine response in major depression.
Joyce PR, Mulder RT, Cloninger CR
J Affect Disord 1994 Jan;30(1):35-46. doi: 10.1016/0165-0327(94)90149-x. PMID: 8151047
Dextroamphetamine and dexamethasone suppression test prediction of desipramine response.
Faber R, Williams K, Prescott D, Bassett D, Bixler G
Biol Psychiatry 1989 Mar 1;25(5):657-60. doi: 10.1016/0006-3223(89)90232-1. PMID: 2920200

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