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Isolated GnRH Deficiency

MedGen UID:
893345
Concept ID:
CN239347
Disease or Syndrome

Professional guidelines

PubMed

Stamou MI, Plummer L, Galli-Tsinopoulou A, Stergidou D, Koika V, Georgopoulos NA
Hormones (Athens) 2019 Mar;18(1):103-105. Epub 2018 Sep 25 doi: 10.1007/s42000-018-0061-1. PMID: 30255480Free PMC Article
Au MG, Crowley WF Jr, Buck CL
Mol Cell Endocrinol 2011 Oct 22;346(1-2):102-9. Epub 2011 Jun 1 doi: 10.1016/j.mce.2011.05.041. PMID: 21664415Free PMC Article
Hall JE
Ann Endocrinol (Paris) 1999 Jul;60(2):93-101. PMID: 10456179

Recent clinical studies

Etiology

Shirazi TN, Self H, Dawood K, Cárdenas R, Welling LLM, Rosenfield KA, Ortiz TL, Carré JM, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts DA
Psychoneuroendocrinology 2020 Sep;119:104733. Epub 2020 Jun 6 doi: 10.1016/j.psyneuen.2020.104733. PMID: 32563936Free PMC Article
Stamou MI, Cox KH, Crowley WF Jr
Endocr Rev 2016 Feb;2016(1):4-22. doi: 10.1210/er.2015-1045.2016.1.test. PMID: 27454361Free PMC Article
Stamou MI, Cox KH, Crowley WF Jr
Endocr Rev 2015 Dec;36(6):603-21. Epub 2015 Sep 22 doi: 10.1210/er.2015-1045. PMID: 26394276Free PMC Article
Chan YM
Mol Cell Endocrinol 2011 Oct 22;346(1-2):51-6. Epub 2011 Jun 22 doi: 10.1016/j.mce.2011.06.013. PMID: 21722705Free PMC Article
Au MG, Crowley WF Jr, Buck CL
Mol Cell Endocrinol 2011 Oct 22;346(1-2):102-9. Epub 2011 Jun 1 doi: 10.1016/j.mce.2011.05.041. PMID: 21664415Free PMC Article

Diagnosis

Shirazi TN, Self H, Dawood K, Cárdenas R, Welling LLM, Rosenfield KA, Ortiz TL, Carré JM, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts DA
Psychoneuroendocrinology 2020 Sep;119:104733. Epub 2020 Jun 6 doi: 10.1016/j.psyneuen.2020.104733. PMID: 32563936Free PMC Article
Balasubramanian R, Crowley WF Jr
Am J Med Genet C Semin Med Genet 2017 Dec;175(4):507-515. Epub 2017 Nov 20 doi: 10.1002/ajmg.c.31585. PMID: 29152903Free PMC Article
Au MG, Crowley WF Jr, Buck CL
Mol Cell Endocrinol 2011 Oct 22;346(1-2):102-9. Epub 2011 Jun 1 doi: 10.1016/j.mce.2011.05.041. PMID: 21664415Free PMC Article
Hayes FJ, Seminara SB, Crowley WF Jr
Endocrinol Metab Clin North Am 1998 Dec;27(4):739-63, vii. doi: 10.1016/s0889-8529(05)70039-6. PMID: 9922906
Quinton R, Duke VM, de Zoysa PA, Platts AD, Valentine A, Kendall B, Pickman S, Kirk JM, Besser GM, Jacobs HS, Bouloux PM
J Clin Endocrinol Metab 1996 Aug;81(8):3010-7. doi: 10.1210/jcem.81.8.8768867. PMID: 8768867

Therapy

Hall JE
Ann Endocrinol (Paris) 1999 Jul;60(2):93-101. PMID: 10456179
Nachtigall LB, Boepple PA, Seminara SB, Khoury RH, Sluss PM, Lecain AE, Crowley WF Jr
J Clin Endocrinol Metab 1996 Oct;81(10):3520-5. doi: 10.1210/jcem.81.10.8855795. PMID: 8855795
Finkelstein JS, Klibanski A, Neer RM, Doppelt SH, Rosenthal DI, Segre GV, Crowley WF Jr
J Clin Endocrinol Metab 1989 Oct;69(4):776-83. doi: 10.1210/jcem-69-4-776. PMID: 2674186
Finkelstein JS, Badger TM, O'Dea LS, Spratt DI, Crowley WF
J Clin Invest 1988 Jun;81(6):1725-33. doi: 10.1172/JCI113512. PMID: 3290251Free PMC Article

Prognosis

Shirazi TN, Self H, Dawood K, Cárdenas R, Welling LLM, Rosenfield KA, Ortiz TL, Carré JM, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts DA
Psychoneuroendocrinology 2020 Sep;119:104733. Epub 2020 Jun 6 doi: 10.1016/j.psyneuen.2020.104733. PMID: 32563936Free PMC Article
Shirazi TN, Self H, Cantor J, Dawood K, Cárdenas R, Rosenfield K, Ortiz T, Carré J, McDaniel MA, Blanchard R, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts D
Horm Behav 2020 May;121:104712. Epub 2020 Feb 18 doi: 10.1016/j.yhbeh.2020.104712. PMID: 32059854Free PMC Article
Cox KH, Oliveira LMB, Plummer L, Corbin B, Gardella T, Balasubramanian R, Crowley WF
Hum Mol Genet 2018 Jan 15;27(2):338-350. doi: 10.1093/hmg/ddx404. PMID: 29161432Free PMC Article
Georgopoulos NA, Pralong FP, Seidman CE, Seidman JG, Crowley WF Jr, Vallejo M
J Clin Endocrinol Metab 1997 Jan;82(1):213-7. doi: 10.1210/jcem.82.1.3692. PMID: 8989261
Nachtigall LB, Boepple PA, Seminara SB, Khoury RH, Sluss PM, Lecain AE, Crowley WF Jr
J Clin Endocrinol Metab 1996 Oct;81(10):3520-5. doi: 10.1210/jcem.81.10.8855795. PMID: 8855795

Clinical prediction guides

Shirazi TN, Self H, Dawood K, Cárdenas R, Welling LLM, Rosenfield KA, Ortiz TL, Carré JM, Balasubramanian R, Delaney A, Crowley W, Breedlove SM, Puts DA
Psychoneuroendocrinology 2020 Sep;119:104733. Epub 2020 Jun 6 doi: 10.1016/j.psyneuen.2020.104733. PMID: 32563936Free PMC Article
Dwyer AA, Chavan NR, Lewkowitz-Shpuntoff H, Plummer L, Hayes FJ, Seminara SB, Crowley WF, Pitteloud N, Balasubramanian R
J Clin Endocrinol Metab 2019 Aug 1;104(8):3403-3414. doi: 10.1210/jc.2018-02697. PMID: 31220265Free PMC Article
Balasubramanian R, Crowley WF Jr
Am J Med Genet C Semin Med Genet 2017 Dec;175(4):507-515. Epub 2017 Nov 20 doi: 10.1002/ajmg.c.31585. PMID: 29152903Free PMC Article
Balasubramanian R, Choi JH, Francescatto L, Willer J, Horton ER, Asimacopoulos EP, Stankovic KM, Plummer L, Buck CL, Quinton R, Nebesio TD, Mericq V, Merino PM, Meyer BF, Monies D, Gusella JF, Al Tassan N, Katsanis N, Crowley WF Jr
Proc Natl Acad Sci U S A 2014 Dec 16;111(50):17953-8. Epub 2014 Dec 3 doi: 10.1073/pnas.1417438111. PMID: 25472840Free PMC Article
Martin C, Balasubramanian R, Dwyer AA, Au MG, Sidis Y, Kaiser UB, Seminara SB, Pitteloud N, Zhou QY, Crowley WF Jr
Endocr Rev 2011 Apr;32(2):225-46. Epub 2010 Oct 29 doi: 10.1210/er.2010-0007. PMID: 21037178Free PMC Article

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