U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cutaneous Malignant Melanoma, Dominant

MedGen UID:
893547
•Concept ID:
CN239351
•
Disease or Syndrome

Professional guidelines

PubMed

Longitudinal genomic alternations and clonal dynamics analysis of primary malignant melanoma of the esophagus.
Li J, Guan W, Ren W, Liu Z, Wu H, Chen Y, Liu S, Quan X, Yang Z, Jiang C, He J, Xiao X, Ye Q
Neoplasia 2022 Aug;30:100811. Epub 2022 Jun 1 doi: 10.1016/j.neo.2022.100811. PMID: 35661532Free PMC Article
Histopathological and immunological spectrum in response evaluation of talimogene laherparepvec treatment and correlation with durable response in patients with cutaneous melanoma.
Mulder EEAP, Damman J, Verver D, van der Veldt AAM, Tas S, Khemai-Mehraban T, Heezen KC, Wouters RA, Verhoef C, Verjans GMGM, Langerak AW, Grünhagen DJ, Mooyaart AL
Melanoma Res 2022 Aug 1;32(4):249-259. Epub 2022 Apr 21 doi: 10.1097/CMR.0000000000000824. PMID: 35446267Free PMC Article
Melanoma susceptibility genes and risk assessment.
Marzuka-Alcalá A, Gabree MJ, Tsao H
Methods Mol Biol 2014;1102:381-93. doi: 10.1007/978-1-62703-727-3_20. PMID: 24258989

Recent clinical studies

Etiology

Prognostic Factors and Clinical Outcomes of Clinical Node-Negative Cutaneous Malignant Melanoma Patients: An Asian Single Institute Study.
Chen YF, Ma H, Perng CK, Feng CJ
Ann Plast Surg 2020 Jan;84(1S Suppl 1):S48-S53. doi: 10.1097/SAP.0000000000002173. PMID: 31833887
Melanoma susceptibility genes and risk assessment.
Marzuka-Alcalá A, Gabree MJ, Tsao H
Methods Mol Biol 2014;1102:381-93. doi: 10.1007/978-1-62703-727-3_20. PMID: 24258989
Head and neck mucosal malignant melanoma: clinicopathologic correlation with contemporary review of prognostic indicators.
Kerr EH, Hameed O, Lewis JS Jr, Bartolucci AA, Wang D, Said-Al-Naief N
Int J Surg Pathol 2012 Feb;20(1):37-46. Epub 2011 Aug 23 doi: 10.1177/1066896911417970. PMID: 21862490
Genetics of pigmentation and melanoma predisposition.
Pho LN, Leachman SA
G Ital Dermatol Venereol 2010 Feb;145(1):37-45. PMID: 20197744
A review of hereditary malignant melanoma including biomarkers in familial atypical multiple mole melanoma syndrome.
Lynch HT, Fusaro RM, Danes BS, Kimberling WJ, Lynch JF
Cancer Genet Cytogenet 1983 Apr;8(4):325-58. doi: 10.1016/0165-4608(83)90075-4. PMID: 6403218

Diagnosis

Longitudinal genomic alternations and clonal dynamics analysis of primary malignant melanoma of the esophagus.
Li J, Guan W, Ren W, Liu Z, Wu H, Chen Y, Liu S, Quan X, Yang Z, Jiang C, He J, Xiao X, Ye Q
Neoplasia 2022 Aug;30:100811. Epub 2022 Jun 1 doi: 10.1016/j.neo.2022.100811. PMID: 35661532Free PMC Article
In vivo two-photon-excited cellular fluorescence of melanin, NAD(P)H, and keratin enables an accurate differential diagnosis of seborrheic keratosis and pigmented cutaneous melanoma.
Szyc Ł, Scharlach C, Haenssle H, Fink C
J Biomed Opt 2021 Jul;26(7) doi: 10.1117/1.JBO.26.7.075002. PMID: 34263578Free PMC Article
Prognostic Factors and Clinical Outcomes of Clinical Node-Negative Cutaneous Malignant Melanoma Patients: An Asian Single Institute Study.
Chen YF, Ma H, Perng CK, Feng CJ
Ann Plast Surg 2020 Jan;84(1S Suppl 1):S48-S53. doi: 10.1097/SAP.0000000000002173. PMID: 31833887
BAP1 Syndrome - Predisposition to Malignant Mesothelioma, Skin and Uveal Melanoma, Renal and Other Cancers.
Foretová L, Navrátilová M, Svoboda M, Házová J, Vašíčková P, Sťahlová EH, Fabian P, Schneiderová M, Macháčková E
Klin Onkol 2019 Summer;32(Supplementum2):118-122. doi: 10.14735/amko2019S118. PMID: 31409087
Primary cutaneous malignant melanoma: experience of the British Columbia Cancer Agency from 1972 to 1981.
Carmichael VE, Wilson KS
Can J Surg 1992 Dec;35(6):589-97. PMID: 1458384

Therapy

Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response.
Kasago IS, Chatila WK, Lezcano CM, Febres-Aldana CA, Schultz N, Vanderbilt C, Dogan S, Bartlett EK, D'Angelo SP, Tap WD, Singer S, Ladanyi M, Shoushtari AN, Busam KJ, Hameed M
Mod Pathol 2023 Aug;36(8):100165. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100165. PMID: 36990277Free PMC Article
An integrative pan cancer analysis of RET aberrations and their potential clinical implications.
Zhou L, Li J, Zhang X, Xu Z, Yan Y, Hu K
Sci Rep 2022 Aug 17;12(1):13913. doi: 10.1038/s41598-022-17791-y. PMID: 35978072Free PMC Article
Histopathological and immunological spectrum in response evaluation of talimogene laherparepvec treatment and correlation with durable response in patients with cutaneous melanoma.
Mulder EEAP, Damman J, Verver D, van der Veldt AAM, Tas S, Khemai-Mehraban T, Heezen KC, Wouters RA, Verhoef C, Verjans GMGM, Langerak AW, Grünhagen DJ, Mooyaart AL
Melanoma Res 2022 Aug 1;32(4):249-259. Epub 2022 Apr 21 doi: 10.1097/CMR.0000000000000824. PMID: 35446267Free PMC Article
Genetics of pigmentation and melanoma predisposition.
Pho LN, Leachman SA
G Ital Dermatol Venereol 2010 Feb;145(1):37-45. PMID: 20197744
Management of primary and metastasized melanoma in Germany in the time period 1976-2005: an analysis of the Central Malignant Melanoma Registry of the German Dermatological Society.
Schwager SS, Leiter U, Buettner PG, Voit C, Marsch W, Gutzmer R, Näher H, Gollnick H, Bröcker EB, Garbe C
Melanoma Res 2008 Apr;18(2):112-9. doi: 10.1097/CMR.0b013e3282f623f1. PMID: 18337647

Prognosis

Survival impact of immediate complete lymph node dissection for Chinese acral and cutaneous melanoma with micrometastasis in sentinel nodes: a retrospective study.
Zhong J, Zou Z, Hu T, Sun W, Wang C, Yan W, Luo Z, Liu X, Xu Y, Chen Y
Clin Exp Med 2023 Nov;23(7):4003-4010. Epub 2023 Jun 10 doi: 10.1007/s10238-023-01107-z. PMID: 37300655Free PMC Article
An integrative pan cancer analysis of RET aberrations and their potential clinical implications.
Zhou L, Li J, Zhang X, Xu Z, Yan Y, Hu K
Sci Rep 2022 Aug 17;12(1):13913. doi: 10.1038/s41598-022-17791-y. PMID: 35978072Free PMC Article
Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019. PMID: 34525340Free PMC Article
Prognostic Factors and Clinical Outcomes of Clinical Node-Negative Cutaneous Malignant Melanoma Patients: An Asian Single Institute Study.
Chen YF, Ma H, Perng CK, Feng CJ
Ann Plast Surg 2020 Jan;84(1S Suppl 1):S48-S53. doi: 10.1097/SAP.0000000000002173. PMID: 31833887
Head and neck mucosal malignant melanoma: clinicopathologic correlation with contemporary review of prognostic indicators.
Kerr EH, Hameed O, Lewis JS Jr, Bartolucci AA, Wang D, Said-Al-Naief N
Int J Surg Pathol 2012 Feb;20(1):37-46. Epub 2011 Aug 23 doi: 10.1177/1066896911417970. PMID: 21862490

Clinical prediction guides

Undifferentiated and Dedifferentiated Metastatic Melanomas Masquerading as Soft Tissue Sarcomas: Mutational Signature Analysis and Immunotherapy Response.
Kasago IS, Chatila WK, Lezcano CM, Febres-Aldana CA, Schultz N, Vanderbilt C, Dogan S, Bartlett EK, D'Angelo SP, Tap WD, Singer S, Ladanyi M, Shoushtari AN, Busam KJ, Hameed M
Mod Pathol 2023 Aug;36(8):100165. Epub 2023 Mar 27 doi: 10.1016/j.modpat.2023.100165. PMID: 36990277Free PMC Article
Genomic profiling with whole-exome sequencing revealed distinct mutations and novel pathways in Asian melanoma.
Chiu YJ, Weng HY, Lin YY, Lin YF, Yeh YC, Perng CK, Ma H, Tsai SF, Chou TY
J Dermatol 2022 Dec;49(12):1299-1309. Epub 2022 Oct 2 doi: 10.1111/1346-8138.16579. PMID: 36184893
Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019. PMID: 34525340Free PMC Article
Prognostic Factors and Clinical Outcomes of Clinical Node-Negative Cutaneous Malignant Melanoma Patients: An Asian Single Institute Study.
Chen YF, Ma H, Perng CK, Feng CJ
Ann Plast Surg 2020 Jan;84(1S Suppl 1):S48-S53. doi: 10.1097/SAP.0000000000002173. PMID: 31833887
A review of hereditary malignant melanoma including biomarkers in familial atypical multiple mole melanoma syndrome.
Lynch HT, Fusaro RM, Danes BS, Kimberling WJ, Lynch JF
Cancer Genet Cytogenet 1983 Apr;8(4):325-58. doi: 10.1016/0165-4608(83)90075-4. PMID: 6403218

Recent systematic reviews

Association of Vitamin D Receptor Gene Polymorphisms With Melanoma Risk: A Meta-analysis and Systematic Review.
Birke M, Schöpe J, Wagenpfeil S, Vogt T, Reichrath J
Anticancer Res 2020 Feb;40(2):583-595. doi: 10.21873/anticanres.13988. PMID: 32014899

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...