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Miscarriage

MedGen UID:
1631411
Concept ID:
C4552766
Pathologic Function
Synonym: Spontaneous abortion
SNOMED CT: Vaginal expulsion of product of conception (17369002); Vaginal expulsion of fetus (17369002); Spontaneous abortion (17369002); Miscarriage (17369002); Vaginal expulsion of foetus (17369002)
 
HPO: HP:0005268

Definition

A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 22th week of pregnancy. [from HPO]

Professional guidelines

PubMed

Dason ES, Maxim M, Sanders A, Papillon-Smith J, Ng D, Chan C, Sobel M
J Obstet Gynaecol Can 2023 Jun;45(6):417-429.e1. doi: 10.1016/j.jogc.2023.04.008. PMID: 37244746
Pesch MH, Saunders NA, Abdelnabi S
J Midwifery Womens Health 2021 May;66(3):397-402. Epub 2021 May 24 doi: 10.1111/jmwh.13228. PMID: 34031974
Passos IMPE, Britto RL
Taiwan J Obstet Gynecol 2020 Mar;59(2):183-188. doi: 10.1016/j.tjog.2020.01.003. PMID: 32127135

Curated

UK NICE Guideline NG126, Ectopic pregnancy and miscarriage: diagnosis and initial management, 2023

Recent clinical studies

Etiology

Tamblyn JA, Pilarski NSP, Markland AD, Marson EJ, Devall A, Hewison M, Morris RK, Coomarasamy A
Fertil Steril 2022 Jul;118(1):111-122. Epub 2022 May 28 doi: 10.1016/j.fertnstert.2022.04.017. PMID: 35637024
Sundermann AC, Zhao S, Young CL, Lam L, Jones SH, Velez Edwards DR, Hartmann KE
Alcohol Clin Exp Res 2019 Aug;43(8):1606-1616. Epub 2019 Jul 3 doi: 10.1111/acer.14124. PMID: 31194258Free PMC Article
Mirza FG, Patki A, Pexman-Fieth C
Gynecol Endocrinol 2016;32(2):97-106. Epub 2016 Jan 22 doi: 10.3109/09513590.2015.1121982. PMID: 26800266
Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SE, Horne AW
Hum Reprod Update 2016 Jan-Feb;22(1):116-33. Epub 2015 Sep 19 doi: 10.1093/humupd/dmv041. PMID: 26386469Free PMC Article
Rai R, Regan L
Lancet 2006 Aug 12;368(9535):601-11. doi: 10.1016/S0140-6736(06)69204-0. PMID: 16905025

Diagnosis

Regan L, Rai R, Saravelos S, Li TC; Royal College of Obstetricians and Gynaecologists
BJOG 2023 Nov;130(12):e9-e39. Epub 2023 Jun 19 doi: 10.1111/1471-0528.17515. PMID: 37334488
McNestry C, Killeen SL, Crowley RK, McAuliffe FM
Acta Obstet Gynecol Scand 2023 May;102(5):523-531. Epub 2023 Feb 17 doi: 10.1111/aogs.14523. PMID: 36799269Free PMC Article
Tamblyn JA, Pilarski NSP, Markland AD, Marson EJ, Devall A, Hewison M, Morris RK, Coomarasamy A
Fertil Steril 2022 Jul;118(1):111-122. Epub 2022 May 28 doi: 10.1016/j.fertnstert.2022.04.017. PMID: 35637024
Beaman J, Prifti C, Schwarz EB, Sobota M
J Gen Intern Med 2020 Aug;35(8):2398-2405. Epub 2020 May 14 doi: 10.1007/s11606-020-05836-9. PMID: 32410127Free PMC Article
Larsen EC, Christiansen OB, Kolte AM, Macklon N
BMC Med 2013 Jun 26;11:154. doi: 10.1186/1741-7015-11-154. PMID: 23803387Free PMC Article

Therapy

Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
Bafort C, Beebeejaun Y, Tomassetti C, Bosteels J, Duffy JM
Cochrane Database Syst Rev 2020 Oct 23;10(10):CD011031. doi: 10.1002/14651858.CD011031.pub3. PMID: 33095458Free PMC Article
Coomarasamy A, Devall AJ, Brosens JJ, Quenby S, Stephenson MD, Sierra S, Christiansen OB, Small R, Brewin J, Roberts TE, Dhillon-Smith R, Harb H, Noordali H, Papadopoulou A, Eapen A, Prior M, Di Renzo GC, Hinshaw K, Mol BW, Lumsden MA, Khalaf Y, Shennan A, Goddijn M, van Wely M, Al-Memar M, Bennett P, Bourne T, Rai R, Regan L, Gallos ID
Am J Obstet Gynecol 2020 Aug;223(2):167-176. Epub 2020 Jan 31 doi: 10.1016/j.ajog.2019.12.006. PMID: 32008730Free PMC Article
Lim SS, Hutchison SK, Van Ryswyk E, Norman RJ, Teede HJ, Moran LJ
Cochrane Database Syst Rev 2019 Mar 28;3(3):CD007506. doi: 10.1002/14651858.CD007506.pub4. PMID: 30921477Free PMC Article
Ghobara T, Gelbaya TA, Ayeleke RO
Cochrane Database Syst Rev 2017 Jul 5;7(7):CD003414. doi: 10.1002/14651858.CD003414.pub3. PMID: 28675921Free PMC Article

Prognosis

Rathore SS, Oberoi S, Hilliard J, Raja R, Ahmed NK, Vishwakarma Y, Iqbal K, Kumari C, Velasquez-Botero F, Nieto-Salazar MA, Cortes GAM, Akomaning E, Musa IEM
Trop Med Int Health 2022 Jul;27(7):619-629. Epub 2022 Jun 11 doi: 10.1111/tmi.13783. PMID: 35689528
Capalbo A, Poli M, Rienzi L, Girardi L, Patassini C, Fabiani M, Cimadomo D, Benini F, Farcomeni A, Cuzzi J, Rubio C, Albani E, Sacchi L, Vaiarelli A, Figliuzzi M, Findikli N, Coban O, Boynukalin FK, Vogel I, Hoffmann E, Livi C, Levi-Setti PE, Ubaldi FM, Simón C
Am J Hum Genet 2021 Dec 2;108(12):2238-2247. Epub 2021 Nov 18 doi: 10.1016/j.ajhg.2021.11.002. PMID: 34798051Free PMC Article
Farren J, Jalmbrant M, Falconieri N, Mitchell-Jones N, Bobdiwala S, Al-Memar M, Tapp S, Van Calster B, Wynants L, Timmerman D, Bourne T
Am J Obstet Gynecol 2020 Apr;222(4):367.e1-367.e22. Epub 2019 Dec 13 doi: 10.1016/j.ajog.2019.10.102. PMID: 31953115
Glasier A, Bhattacharya S, Evers H, Gemzell-Danielsson K, Hardman S, Heikinheimo O, La Vecchia C, Somigliana E; Annual Capri Workshop Group
Acta Obstet Gynecol Scand 2019 Nov;98(11):1378-1385. Epub 2019 May 13 doi: 10.1111/aogs.13627. PMID: 31001809
Phillips J, Millum J
Bioethics 2015 Jul;29(6):413-23. Epub 2014 Nov 14 doi: 10.1111/bioe.12120. PMID: 25395144Free PMC Article

Clinical prediction guides

Meng LC, Lin CW, Chuang HM, Chen LK, Hsiao FY
JAMA Psychiatry 2024 Apr 1;81(4):366-373. doi: 10.1001/jamapsychiatry.2023.4912. PMID: 38150230Free PMC Article
Tamblyn JA, Pilarski NSP, Markland AD, Marson EJ, Devall A, Hewison M, Morris RK, Coomarasamy A
Fertil Steril 2022 Jul;118(1):111-122. Epub 2022 May 28 doi: 10.1016/j.fertnstert.2022.04.017. PMID: 35637024
du Fossé NA, van der Hoorn MP, van Lith JMM, le Cessie S, Lashley EELO
Hum Reprod Update 2020 Sep 1;26(5):650-669. doi: 10.1093/humupd/dmaa010. PMID: 32358607Free PMC Article
Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Sep 1;106(3):530-40. Epub 2016 May 25 doi: 10.1016/j.fertnstert.2016.05.014. PMID: 27235766
Bottomley C, Bourne T
Best Pract Res Clin Obstet Gynaecol 2009 Aug;23(4):463-77. Epub 2009 Jun 6 doi: 10.1016/j.bpobgyn.2009.02.004. PMID: 19502113

Recent systematic reviews

Zhang S, Han X, Liu W, Wen Q, Wang J
Arch Gynecol Obstet 2023 Jul;308(1):63-71. Epub 2022 Aug 1 doi: 10.1007/s00404-022-06718-7. PMID: 35913558
Tamblyn JA, Pilarski NSP, Markland AD, Marson EJ, Devall A, Hewison M, Morris RK, Coomarasamy A
Fertil Steril 2022 Jul;118(1):111-122. Epub 2022 May 28 doi: 10.1016/j.fertnstert.2022.04.017. PMID: 35637024
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
Bafort C, Beebeejaun Y, Tomassetti C, Bosteels J, Duffy JM
Cochrane Database Syst Rev 2020 Oct 23;10(10):CD011031. doi: 10.1002/14651858.CD011031.pub3. PMID: 33095458Free PMC Article
Sundermann AC, Zhao S, Young CL, Lam L, Jones SH, Velez Edwards DR, Hartmann KE
Alcohol Clin Exp Res 2019 Aug;43(8):1606-1616. Epub 2019 Jul 3 doi: 10.1111/acer.14124. PMID: 31194258Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG126, Ectopic pregnancy and miscarriage: diagnosis and initial management, 2023

    Consumer resources

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