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Nesiritide response

MedGen UID:
983160
Concept ID:
CN298373
Sign or Symptom
Drug:
nesiritide
MedGen UID:
27614
Concept ID:
C0054015
Pharmacologic Substance
A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation. [from NCI]

Professional guidelines

PubMed

Tsutsui H, Albert NM, Coats AJS, Anker SD, Bayes-Genis A, Butler J, Chioncel O, Defilippi CR, Drazner MH, Felker GM, Filippatos G, Fiuzat M, Ide T, Januzzi JL Jr, Kinugawa K, Kuwahara K, Matsue Y, Mentz RJ, Metra M, Pandey A, Rosano G, Saito Y, Sakata Y, Sato N, Seferovic PM, Teerlink J, Yamamoto K, Yoshimura M
J Card Fail 2023 May;29(5):787-804. Epub 2023 Apr 17 doi: 10.1016/j.cardfail.2023.02.009. PMID: 37117140
Tsutsui H, Albert NM, Coats AJS, Anker SD, Bayes-Genis A, Butler J, Chioncel O, Defilippi CR, Drazner MH, Felker GM, Filippatos G, Fiuzat M, Ide T, Januzzi JL Jr, Kinugawa K, Kuwahara K, Matsue Y, Mentz RJ, Metra M, Pandey A, Rosano G, Saito Y, Sakata Y, Sato N, Seferovic PM, Teerlink J, Yamamoto K, Yoshimura M
Eur J Heart Fail 2023 May;25(5):616-631. Epub 2023 Apr 26 doi: 10.1002/ejhf.2848. PMID: 37098791
Ingbar DH
Curr Opin Crit Care 2019 Aug;25(4):371-378. doi: 10.1097/MCC.0000000000000626. PMID: 31116110

Curated

DailyMed Drug Label, nesiritide, 2019

Recent clinical studies

Etiology

Mohebi R, Liu Y, Piña IL, Prescott MF, Butler J, Felker GM, Ward JH, Solomon SD, Januzzi JL Jr
J Am Coll Cardiol 2022 Oct 18;80(16):1529-1541. doi: 10.1016/j.jacc.2022.08.737. PMID: 36229089
Myhre PL, Vaduganathan M, Claggett BL, Miao ZM, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Lindholm D, Petersson M, Langkilde AM, McMurray JJV, Solomon SD
JACC Heart Fail 2022 Dec;10(12):902-913. Epub 2022 Aug 27 doi: 10.1016/j.jchf.2022.08.007. PMID: 36114137
Senni M, Lopez-Sendon J, Cohen-Solal A, Ponikowski P, Nkulikiyinka R, Freitas C, Vlajnic VM, Roessig L, Pieske B
ESC Heart Fail 2022 Dec;9(6):3791-3803. Epub 2022 Jul 26 doi: 10.1002/ehf2.14050. PMID: 35880474Free PMC Article
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article
Damman K, Beusekamp JC, Boorsma EM, Swart HP, Smilde TDJ, Elvan A, van Eck JWM, Heerspink HJL, Voors AA
Eur J Heart Fail 2020 Apr;22(4):713-722. Epub 2020 Jan 7 doi: 10.1002/ejhf.1713. PMID: 31912605

Diagnosis

Martens P, Dauw J, Verbrugge FH, Nijst P, Meekers E, Augusto SN Jr, Ter Maaten JM, Damman K, Mebazaa A, Filippatos G, Ruschitzka F, Tang WHW, Dupont M, Mullens W
Circulation 2023 Jan 17;147(3):201-211. Epub 2022 Nov 6 doi: 10.1161/CIRCULATIONAHA.122.062486. PMID: 36335479
Rosenkranz S, Pausch C, Coghlan JG, Huscher D, Pittrow D, Grünig E, Staehler G, Vizza CD, Gall H, Distler O, Delcroix M, Ghofrani HA, Ewert R, Kabitz HJ, Skowasch D, Behr J, Milger K, Halank M, Wilkens H, Seyfarth HJ, Held M, Scelsi L, Neurohr C, Vonk-Noordegraaf A, Ulrich S, Klose H, Claussen M, Eisenmann S, Schmidt KH, Remppis BA, Skride A, Jureviciene E, Gumbiene L, Miliauskas S, Löffler-Ragg J, Lange TJ, Olsson KM, Hoeper MM, Opitz C
J Heart Lung Transplant 2023 Jan;42(1):102-114. Epub 2022 Oct 13 doi: 10.1016/j.healun.2022.10.003. PMID: 36333206
Mohebi R, Liu Y, Piña IL, Prescott MF, Butler J, Felker GM, Ward JH, Solomon SD, Januzzi JL Jr
J Am Coll Cardiol 2022 Oct 18;80(16):1529-1541. doi: 10.1016/j.jacc.2022.08.737. PMID: 36229089
Garatti L, Frea S, Bocchino PP, Angelini F, Cingolani M, Sacco A, Rondinara GM, Bagnardi V, Sala IM, Kapur NK, Colombo PC, De Ferrari GM, Morici N
Int J Cardiol 2022 Dec 15;369:37-44. Epub 2022 Aug 6 doi: 10.1016/j.ijcard.2022.08.009. PMID: 35944767Free PMC Article
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article

Therapy

Humbert M, McLaughlin V, Gibbs JSR, Gomberg-Maitland M, Hoeper MM, Preston IR, Souza R, Waxman A, Escribano Subias P, Feldman J, Meyer G, Montani D, Olsson KM, Manimaran S, Barnes J, Linde PG, de Oliveira Pena J, Badesch DB; PULSAR Trial Investigators
N Engl J Med 2021 Apr 1;384(13):1204-1215. doi: 10.1056/NEJMoa2024277. PMID: 33789009
Cox ZL, Collins SP, Aaron M, Hernandez GA, Iii ATM, Davidson BT, Fowler M, Lindsell CJ, Jr FEH, Jenkins CA, Kampe C, Miller KF, Stubblefield WB, Lindenfeld J
Am Heart J 2021 Feb;232:116-124. Epub 2020 Nov 2 doi: 10.1016/j.ahj.2020.10.071. PMID: 33144086
Damman K, Beusekamp JC, Boorsma EM, Swart HP, Smilde TDJ, Elvan A, van Eck JWM, Heerspink HJL, Voors AA
Eur J Heart Fail 2020 Apr;22(4):713-722. Epub 2020 Jan 7 doi: 10.1002/ejhf.1713. PMID: 31912605
Velazquez EJ, Morrow DA, DeVore AD, Duffy CI, Ambrosy AP, McCague K, Rocha R, Braunwald E; PIONEER-HF Investigators
N Engl J Med 2019 Feb 7;380(6):539-548. Epub 2018 Nov 11 doi: 10.1056/NEJMoa1812851. PMID: 30415601
Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, McLaughlin VV, Peacock AJ, Simonneau G, Vachiery JL, Grünig E, Oudiz RJ, Vonk-Noordegraaf A, White RJ, Blair C, Gillies H, Miller KL, Harris JH, Langley J, Rubin LJ; AMBITION Investigators
N Engl J Med 2015 Aug 27;373(9):834-44. doi: 10.1056/NEJMoa1413687. PMID: 26308684

Prognosis

Rosenkranz S, Pausch C, Coghlan JG, Huscher D, Pittrow D, Grünig E, Staehler G, Vizza CD, Gall H, Distler O, Delcroix M, Ghofrani HA, Ewert R, Kabitz HJ, Skowasch D, Behr J, Milger K, Halank M, Wilkens H, Seyfarth HJ, Held M, Scelsi L, Neurohr C, Vonk-Noordegraaf A, Ulrich S, Klose H, Claussen M, Eisenmann S, Schmidt KH, Remppis BA, Skride A, Jureviciene E, Gumbiene L, Miliauskas S, Löffler-Ragg J, Lange TJ, Olsson KM, Hoeper MM, Opitz C
J Heart Lung Transplant 2023 Jan;42(1):102-114. Epub 2022 Oct 13 doi: 10.1016/j.healun.2022.10.003. PMID: 36333206
Mohebi R, Liu Y, Piña IL, Prescott MF, Butler J, Felker GM, Ward JH, Solomon SD, Januzzi JL Jr
J Am Coll Cardiol 2022 Oct 18;80(16):1529-1541. doi: 10.1016/j.jacc.2022.08.737. PMID: 36229089
Myhre PL, Vaduganathan M, Claggett BL, Miao ZM, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Lindholm D, Petersson M, Langkilde AM, McMurray JJV, Solomon SD
JACC Heart Fail 2022 Dec;10(12):902-913. Epub 2022 Aug 27 doi: 10.1016/j.jchf.2022.08.007. PMID: 36114137
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article
Cox ZL, Collins SP, Aaron M, Hernandez GA, Iii ATM, Davidson BT, Fowler M, Lindsell CJ, Jr FEH, Jenkins CA, Kampe C, Miller KF, Stubblefield WB, Lindenfeld J
Am Heart J 2021 Feb;232:116-124. Epub 2020 Nov 2 doi: 10.1016/j.ahj.2020.10.071. PMID: 33144086

Clinical prediction guides

Mohebi R, Liu Y, Piña IL, Prescott MF, Butler J, Felker GM, Ward JH, Solomon SD, Januzzi JL Jr
J Am Coll Cardiol 2022 Oct 18;80(16):1529-1541. doi: 10.1016/j.jacc.2022.08.737. PMID: 36229089
Senni M, Lopez-Sendon J, Cohen-Solal A, Ponikowski P, Nkulikiyinka R, Freitas C, Vlajnic VM, Roessig L, Pieske B
ESC Heart Fail 2022 Dec;9(6):3791-3803. Epub 2022 Jul 26 doi: 10.1002/ehf2.14050. PMID: 35880474Free PMC Article
Castiglione V, Aimo A, Vergaro G, Saccaro L, Passino C, Emdin M
Heart Fail Rev 2022 Mar;27(2):625-643. Epub 2021 Apr 14 doi: 10.1007/s10741-021-10105-w. PMID: 33852110Free PMC Article
Damman K, Beusekamp JC, Boorsma EM, Swart HP, Smilde TDJ, Elvan A, van Eck JWM, Heerspink HJL, Voors AA
Eur J Heart Fail 2020 Apr;22(4):713-722. Epub 2020 Jan 7 doi: 10.1002/ejhf.1713. PMID: 31912605
Doran JP, Veale DJ
Rheumatology (Oxford) 2008 Oct;47 Suppl 5:v36-8. doi: 10.1093/rheumatology/ken270. PMID: 18784139

Recent systematic reviews

Su X, Lei T, Yu H, Zhang L, Feng Z, Shuai T, Guo H, Liu J
Int J Chron Obstruct Pulmon Dis 2023;18:811-825. Epub 2023 May 10 doi: 10.2147/COPD.S396663. PMID: 37197601Free PMC Article
Montellano FA, Ungethüm K, Ramiro L, Nacu A, Hellwig S, Fluri F, Whiteley WN, Bustamante A, Montaner J, Heuschmann PU
Stroke 2021 Jan;52(2):543-551. Epub 2021 Jan 12 doi: 10.1161/STROKEAHA.120.029232. PMID: 33430636
Ploegstra MJ, Zijlstra WMH, Douwes JM, Hillege HL, Berger RMF
Int J Cardiol 2015 Apr 1;184:198-207. Epub 2015 Jan 27 doi: 10.1016/j.ijcard.2015.01.038. PMID: 25706327
Kulkarni M, Gokulakrishnan G, Price J, Fernandes CJ, Leeflang M, Pammi M
Pediatrics 2015 Feb;135(2):e510-25. Epub 2015 Jan 19 doi: 10.1542/peds.2014-1995. PMID: 25601976
Balion C, Santaguida PL, Hill S, Worster A, McQueen M, Oremus M, McKelvie R, Booker L, Fagbemi J, Reichert S, Raina P
Evid Rep Technol Assess (Full Rep) 2006 Sep;(142):1-147. PMID: 17764210Free PMC Article

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