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Aging

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
Synonym: AGING
SNOMED CT: Aging (248280005)
 
OMIM®: 502000

Definition

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from OMIM]

Recent systematic reviews

Tran KH, McDonald AP, D'Arcy RCN, Song X
Clin Interv Aging 2021;16:345-361. Epub 2021 Feb 24 doi: 10.2147/CIA.S287619. PMID: 33658771Free PMC Article
Aung HL, Aghvinian M, Gouse H, Robbins RN, Brew BJ, Mao L, Cysique LA
AIDS Behav 2021 Mar;25(3):917-960. Epub 2020 Oct 6 doi: 10.1007/s10461-020-03053-3. PMID: 33025390Free PMC Article
Reich AJ, Claunch KD, Verdeja MA, Dungan MT, Anderson S, Clayton CK, Goates MC, Thacker EL
J Cross Cult Gerontol 2020 Dec;35(4):455-478. Epub 2020 Oct 16 doi: 10.1007/s10823-020-09416-6. PMID: 33064233
Lin YH, Chen YC, Tseng YC, Tsai ST, Tseng YH
Aging (Albany NY) 2020 Apr 29;12(9):7704-7716. doi: 10.18632/aging.103057. PMID: 32350152Free PMC Article
Hausknecht S, Low LF, O'Loughlin K, McNab J, Clemson L
Gerontologist 2020 Sep 15;60(7):e524-e534. doi: 10.1093/geront/gnz153. PMID: 31872232

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