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Rectal Adenocarcinoma

MedGen UID:
56214
Concept ID:
C0149978
Neoplastic Process
Synonyms: adenocarcinoma - rectum; Adenocarcinoma of rectum; Adenocarcinoma of Rectum; adenocarcinoma of rectum; Adenocarcinoma of the Rectum; adenocarcinoma of the rectum; read; rectal adenocarcinoma; rectum adenocarcinoma
SNOMED CT: Adenocarcinoma of rectum (254582000)
 
Monarch Initiative: MONDO:0002169

Definition

An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [from NCI]

Recent clinical studies

Etiology

Kumar NA, Desouza A, Ostwal V, Sasi SP, Verma K, Ramaswamy A, Engineer R, Saklani A
Langenbecks Arch Surg 2021 May;406(3):821-831. Epub 2021 Mar 17 doi: 10.1007/s00423-021-02143-7. PMID: 33733285
Chen W, Li L, Yan Z, Hu S, Feng J, Liu G, Liu B, Liu X
Eur Radiol 2021 May;31(5):3286-3296. Epub 2020 Oct 30 doi: 10.1007/s00330-020-07397-1. PMID: 33125558
Sell NM, Qwaider YZ, Goldstone RN, Cauley CE, Cusack JC, Ricciardi R, Bordeianou LG, Berger DL, Kunitake H
J Surg Oncol 2021 Jan;123(1):293-298. Epub 2020 Oct 6 doi: 10.1002/jso.26247. PMID: 33022797
Li L, Chen W, Yan Z, Feng J, Hu S, Liu B, Liu X
J Magn Reson Imaging 2020 Nov;52(5):1487-1496. Epub 2020 Jun 10 doi: 10.1002/jmri.27212. PMID: 32524685
Ke J, Tian J, Mei S, Ying P, Yang N, Wang X, Zou D, Peng X, Yang Y, Zhu Y, Gong Y, Wang Z, Gong J, Zhong R, Chang J, Miao X
Cancer Epidemiol Biomarkers Prev 2020 Apr;29(4):850-859. Epub 2020 Jan 27 doi: 10.1158/1055-9965.EPI-19-1116. PMID: 31988071

Diagnosis

Casalots A, Serra-Aracil X, Mora-Lopez L, Garcia-Nalda A, Pericay C, Ferreres JC, Navarro-Soto S
J Gastrointest Surg 2021 Oct;25(10):2660-2667. Epub 2021 Feb 24 doi: 10.1007/s11605-021-04948-9. PMID: 33629231
Chen W, Li L, Yan Z, Hu S, Feng J, Liu G, Liu B, Liu X
Eur Radiol 2021 May;31(5):3286-3296. Epub 2020 Oct 30 doi: 10.1007/s00330-020-07397-1. PMID: 33125558
Li L, Chen W, Yan Z, Feng J, Hu S, Liu B, Liu X
J Magn Reson Imaging 2020 Nov;52(5):1487-1496. Epub 2020 Jun 10 doi: 10.1002/jmri.27212. PMID: 32524685
Margalit O, Mamtani R, Kopetz S, Yang YX, Lawrence YR, Abu-Gazala S, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Shacham-Shmueli E, Boursi B
Oncologist 2019 Aug;24(8):e671-e676. Epub 2019 Jan 29 doi: 10.1634/theoncologist.2018-0333. PMID: 30696723Free PMC Article
Runau F, Collins A, Fenech GA, Ford E, Dimitriou N, Chaudhri S, Yeung JM
Int J Colorectal Dis 2017 Mar;32(3):341-348. Epub 2016 Nov 24 doi: 10.1007/s00384-016-2712-5. PMID: 27885480

Therapy

Huang CW, Su WC, Chang TK, Ma CJ, Yin TC, Tsai HL, Chen PJ, Chen YC, Li CC, Hsieh YC, Wang JY
World J Surg Oncol 2020 Nov 25;18(1):308. doi: 10.1186/s12957-020-02086-1. PMID: 33239020Free PMC Article
Renz P, Wegner RE, Hasan S, Brookover R, Finley G, Monga D, Raj M, McCormick J, Kirichenko A
Clin Colorectal Cancer 2019 Jun;18(2):e237-e243. Epub 2019 Feb 5 doi: 10.1016/j.clcc.2018.12.005. PMID: 30905549Free PMC Article
Margalit O, Mamtani R, Kopetz S, Yang YX, Lawrence YR, Abu-Gazala S, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Shacham-Shmueli E, Boursi B
Oncologist 2019 Aug;24(8):e671-e676. Epub 2019 Jan 29 doi: 10.1634/theoncologist.2018-0333. PMID: 30696723Free PMC Article
Watanabe M, Tada M, Satomi T, Chikazu D, Mizumoto M, Sakurai H
World J Surg Oncol 2016 Jul 29;14(1):199. doi: 10.1186/s12957-016-0958-6. PMID: 27473859Free PMC Article
Majbar AM, Abid M, Alaoui M, Sabbah F, Raiss M, Ahallat M, Hrora A
J Laparoendosc Adv Surg Tech A 2016 Sep;26(9):697-701. Epub 2016 Jul 7 doi: 10.1089/lap.2016.0027. PMID: 27388931

Prognosis

Kumar NA, Desouza A, Ostwal V, Sasi SP, Verma K, Ramaswamy A, Engineer R, Saklani A
Langenbecks Arch Surg 2021 May;406(3):821-831. Epub 2021 Mar 17 doi: 10.1007/s00423-021-02143-7. PMID: 33733285
Chen W, Li L, Yan Z, Hu S, Feng J, Liu G, Liu B, Liu X
Eur Radiol 2021 May;31(5):3286-3296. Epub 2020 Oct 30 doi: 10.1007/s00330-020-07397-1. PMID: 33125558
Li L, Chen W, Yan Z, Feng J, Hu S, Liu B, Liu X
J Magn Reson Imaging 2020 Nov;52(5):1487-1496. Epub 2020 Jun 10 doi: 10.1002/jmri.27212. PMID: 32524685
Jia RZ, Zhang JZ, Jing CQ, Li CS, Zhuo HQ
J Recept Signal Transduct Res 2020 Jun;40(3):257-263. Epub 2020 Feb 26 doi: 10.1080/10799893.2020.1731534. PMID: 32098557
Wu DD, Liu SY, Gao YR, Lu D, Hong Y, Chen YG, Dong PZ, Wang DY, Li T, Li HM, Ren ZG, Guo JC, He F, Ren XQ, Sun SY, Duan SF, Ji XY
J Cell Mol Med 2019 Mar;23(3):1698-1713. Epub 2019 Jan 13 doi: 10.1111/jcmm.14065. PMID: 30637920Free PMC Article

Clinical prediction guides

Casalots A, Serra-Aracil X, Mora-Lopez L, Garcia-Nalda A, Pericay C, Ferreres JC, Navarro-Soto S
J Gastrointest Surg 2021 Oct;25(10):2660-2667. Epub 2021 Feb 24 doi: 10.1007/s11605-021-04948-9. PMID: 33629231
Chen W, Li L, Yan Z, Hu S, Feng J, Liu G, Liu B, Liu X
Eur Radiol 2021 May;31(5):3286-3296. Epub 2020 Oct 30 doi: 10.1007/s00330-020-07397-1. PMID: 33125558
Huang CW, Su WC, Chang TK, Ma CJ, Yin TC, Tsai HL, Chen PJ, Chen YC, Li CC, Hsieh YC, Wang JY
World J Surg Oncol 2020 Nov 25;18(1):308. doi: 10.1186/s12957-020-02086-1. PMID: 33239020Free PMC Article
Li L, Chen W, Yan Z, Feng J, Hu S, Liu B, Liu X
J Magn Reson Imaging 2020 Nov;52(5):1487-1496. Epub 2020 Jun 10 doi: 10.1002/jmri.27212. PMID: 32524685
Margalit O, Mamtani R, Kopetz S, Yang YX, Lawrence YR, Abu-Gazala S, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Shacham-Shmueli E, Boursi B
Oncologist 2019 Aug;24(8):e671-e676. Epub 2019 Jan 29 doi: 10.1634/theoncologist.2018-0333. PMID: 30696723Free PMC Article

Recent systematic reviews

Butterworth JW, Butterworth WA, Meyer J, Giacobino C, Buchs N, Ris F, Scarpinata R
Tech Coloproctol 2021 Nov;25(11):1183-1198. Epub 2021 Sep 25 doi: 10.1007/s10151-021-02515-7. PMID: 34562160
Davey S, McCarthy K
In Vivo 2020 Sep-Oct;34(5):2193-2199. doi: 10.21873/invivo.12029. PMID: 32871741Free PMC Article
Sasikumar A, Bhan C, Jenkins JT, Antoniou A, Murphy J
Dis Colon Rectum 2017 Mar;60(3):346-352. doi: 10.1097/DCR.0000000000000737. PMID: 28177998
McCawley N, Clancy C, O'Neill BD, Deasy J, McNamara DA, Burke JP
Dis Colon Rectum 2016 Dec;59(12):1200-1208. doi: 10.1097/DCR.0000000000000635. PMID: 27824706
Kidane B, Chadi SA, Kanters S, Colquhoun PH, Ott MC
Dis Colon Rectum 2015 Jan;58(1):122-40. doi: 10.1097/DCR.0000000000000293. PMID: 25489704

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