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Social disinhibition

MedGen UID:
140859
•Concept ID:
C0424296
•
Mental or Behavioral Dysfunction
Synonym: Disinhibition
SNOMED CT: Lack of restraint in social settings (247977003); Social disinhibition (247977003)
 
HPO: HP:5200029

Definition

Unrestrained behavior, often at odds with social norms. [from NCI]

Professional guidelines

PubMed

Development and Validation of a Measure of Attachment Disorders Based on DSM-5 Criteria: The Early TRAuma-Related Disorders Questionnaire (ETRADQ).
Monette S, Cyr C, Terradas MM, Couture S, Minnis H, Lehmann S
Assessment 2022 Apr;29(3):556-571. Epub 2020 Dec 31 doi: 10.1177/1073191120981763. PMID: 33380162
Interventional psychiatry in the management of behavioural and psychological symptoms of dementia: a qualitative review.
Swierkosz-Lenart K, Mall JF, von Gunten A
Swiss Med Wkly 2019 Oct 21;149:w20140. Epub 2019 Oct 27 doi: 10.4414/smw.2019.20140. PMID: 31656033
Hyposmia, not emotion perception, is associated with psychosocial outcome after severe traumatic brain injury.
Osborne-Crowley K, McDonald S
Neuropsychology 2016 Oct;30(7):820-9. Epub 2016 May 5 doi: 10.1037/neu0000293. PMID: 27149553

Recent clinical studies

Etiology

Development and Validation of a Measure of Attachment Disorders Based on DSM-5 Criteria: The Early TRAuma-Related Disorders Questionnaire (ETRADQ).
Monette S, Cyr C, Terradas MM, Couture S, Minnis H, Lehmann S
Assessment 2022 Apr;29(3):556-571. Epub 2020 Dec 31 doi: 10.1177/1073191120981763. PMID: 33380162
Interventional psychiatry in the management of behavioural and psychological symptoms of dementia: a qualitative review.
Swierkosz-Lenart K, Mall JF, von Gunten A
Swiss Med Wkly 2019 Oct 21;149:w20140. Epub 2019 Oct 27 doi: 10.4414/smw.2019.20140. PMID: 31656033
Examining the language and behavioural profile in FTD and ALS-FTD.
Saxon JA, Thompson JC, Jones M, Harris JM, Richardson AM, Langheinrich T, Neary D, Mann DM, Snowden JS
J Neurol Neurosurg Psychiatry 2017 Aug;88(8):675-680. Epub 2017 Jun 8 doi: 10.1136/jnnp-2017-315667. PMID: 28596248Free PMC Article
Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth.
Archer NP, Wilkinson AV, Ranjit N, Wang J, Zhao H, Swann AC, Shete S
Brain Behav 2014 Jul;4(4):521-30. Epub 2014 May 16 doi: 10.1002/brb3.236. PMID: 25161819Free PMC Article
The social anxiety spectrum.
Schneier FR, Blanco C, Antia SX, Liebowitz MR
Psychiatr Clin North Am 2002 Dec;25(4):757-74. doi: 10.1016/s0193-953x(02)00018-7. PMID: 12462859

Diagnosis

Development and Validation of a Measure of Attachment Disorders Based on DSM-5 Criteria: The Early TRAuma-Related Disorders Questionnaire (ETRADQ).
Monette S, Cyr C, Terradas MM, Couture S, Minnis H, Lehmann S
Assessment 2022 Apr;29(3):556-571. Epub 2020 Dec 31 doi: 10.1177/1073191120981763. PMID: 33380162
Development and Examination of the Reactive Attachment Disorder and Disinhibited Social Engagement Disorder Assessment Interview.
Lehmann S, Monette S, Egger H, Breivik K, Young D, Davidson C, Minnis H
Assessment 2020 Jun;27(4):749-765. Epub 2018 Sep 2 doi: 10.1177/1073191118797422. PMID: 30175603Free PMC Article
Examining the language and behavioural profile in FTD and ALS-FTD.
Saxon JA, Thompson JC, Jones M, Harris JM, Richardson AM, Langheinrich T, Neary D, Mann DM, Snowden JS
J Neurol Neurosurg Psychiatry 2017 Aug;88(8):675-680. Epub 2017 Jun 8 doi: 10.1136/jnnp-2017-315667. PMID: 28596248Free PMC Article
The behavioral phenotype of Williams syndrome: A recognizable pattern of neurodevelopment.
Morris CA
Am J Med Genet C Semin Med Genet 2010 Nov 15;154C(4):427-31. doi: 10.1002/ajmg.c.30286. PMID: 20981771
The social anxiety spectrum.
Schneier FR, Blanco C, Antia SX, Liebowitz MR
Psychiatr Clin North Am 2002 Dec;25(4):757-74. doi: 10.1016/s0193-953x(02)00018-7. PMID: 12462859

Therapy

Interventional psychiatry in the management of behavioural and psychological symptoms of dementia: a qualitative review.
Swierkosz-Lenart K, Mall JF, von Gunten A
Swiss Med Wkly 2019 Oct 21;149:w20140. Epub 2019 Oct 27 doi: 10.4414/smw.2019.20140. PMID: 31656033
Inhibiting automatic negative social responses in alcohol intoxication: interactions with theory of mind ability and level of task guidance.
Johnson EG, Skromanis S, Bruno R, Mond J, Honan CA
Psychopharmacology (Berl) 2018 Apr;235(4):1221-1232. Epub 2018 Feb 1 doi: 10.1007/s00213-018-4838-3. PMID: 29392372
Schizophrenia or neurodegenerative disease prodrome? Outcome of a first psychotic episode in a 35-year-old woman.
Khan BK, Woolley JD, Chao S, See T, Karydas AM, Miller BL, Rankin KP
Psychosomatics 2012 May-Jun;53(3):280-4. Epub 2012 Jan 28 doi: 10.1016/j.psym.2011.04.005. PMID: 22284422Free PMC Article
Alcohol-induced disinhibition expectancies and impaired control as prospective predictors of problem drinking in undergraduates.
Leeman RF, Toll BA, Taylor LA, Volpicelli JR
Psychol Addict Behav 2009 Dec;23(4):553-63. doi: 10.1037/a0017129. PMID: 20025361Free PMC Article
"Frontal variant Alzheimer's disease": a reappraisal.
Larner AJ
Clin Neurol Neurosurg 2006 Oct;108(7):705-8. Epub 2005 Aug 15 doi: 10.1016/j.clineuro.2005.07.001. PMID: 16102893

Prognosis

The prevalence, predictors, associated symptoms, and outcomes of social disinhibition following moderate-to-severe TBI: A scoping review of quantitative evidence.
Filipčíková M, Wearne T, Li R, McDonald S
J Clin Exp Neuropsychol 2021 Sep;43(7):716-736. Epub 2021 Dec 20 doi: 10.1080/13803395.2021.2000589. PMID: 34930093
Role of Reversal Learning Impairment in Social Disinhibition following Severe Traumatic Brain Injury.
Osborne-Crowley K, McDonald S, Rushby JA
J Int Neuropsychol Soc 2016 Mar;22(3):303-13. Epub 2016 Jan 12 doi: 10.1017/S1355617715001277. PMID: 26754292
Development of an observational measure of social disinhibition after traumatic brain injury.
Osborne-Crowley K, McDonald S, Francis H
J Clin Exp Neuropsychol 2016;38(3):341-53. Epub 2015 Dec 17 doi: 10.1080/13803395.2015.1115824. PMID: 26678068
Alcohol-induced disinhibition expectancies and impaired control as prospective predictors of problem drinking in undergraduates.
Leeman RF, Toll BA, Taylor LA, Volpicelli JR
Psychol Addict Behav 2009 Dec;23(4):553-63. doi: 10.1037/a0017129. PMID: 20025361Free PMC Article
The role of adolescent social disinhibition expectancies in moderating the relationship between psychological distress and alcohol use and misuse.
Cable N, Sacker A
Addict Behav 2007 Feb;32(2):282-95. Epub 2006 Jun 27 doi: 10.1016/j.addbeh.2006.04.001. PMID: 16806722

Clinical prediction guides

An ecological approach to identify distinct neural correlates of disinhibition in frontotemporal dementia.
Tanguy D, Batrancourt B, Estudillo-Romero A, Baxter JSH, Le Ber I, Bouzigues A, Godefroy V, Funkiewiez A, Chamayou C, Volle E, Saracino D, Rametti-Lacroux A, Morandi X, Jannin P, Levy R, Migliaccio R; ECOCAPTURE study group
Neuroimage Clin 2022;35:103079. Epub 2022 Jun 7 doi: 10.1016/j.nicl.2022.103079. PMID: 35700600Free PMC Article
The prevalence, predictors, associated symptoms, and outcomes of social disinhibition following moderate-to-severe TBI: A scoping review of quantitative evidence.
Filipčíková M, Wearne T, Li R, McDonald S
J Clin Exp Neuropsychol 2021 Sep;43(7):716-736. Epub 2021 Dec 20 doi: 10.1080/13803395.2021.2000589. PMID: 34930093
Development and Examination of the Reactive Attachment Disorder and Disinhibited Social Engagement Disorder Assessment Interview.
Lehmann S, Monette S, Egger H, Breivik K, Young D, Davidson C, Minnis H
Assessment 2020 Jun;27(4):749-765. Epub 2018 Sep 2 doi: 10.1177/1073191118797422. PMID: 30175603Free PMC Article
Development of an observational measure of social disinhibition after traumatic brain injury.
Osborne-Crowley K, McDonald S, Francis H
J Clin Exp Neuropsychol 2016;38(3):341-53. Epub 2015 Dec 17 doi: 10.1080/13803395.2015.1115824. PMID: 26678068
Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth.
Archer NP, Wilkinson AV, Ranjit N, Wang J, Zhao H, Swann AC, Shete S
Brain Behav 2014 Jul;4(4):521-30. Epub 2014 May 16 doi: 10.1002/brb3.236. PMID: 25161819Free PMC Article

Recent systematic reviews

The prevalence, predictors, associated symptoms, and outcomes of social disinhibition following moderate-to-severe TBI: A scoping review of quantitative evidence.
Filipčíková M, Wearne T, Li R, McDonald S
J Clin Exp Neuropsychol 2021 Sep;43(7):716-736. Epub 2021 Dec 20 doi: 10.1080/13803395.2021.2000589. PMID: 34930093

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