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Sunitinib

An indole and pyrrole derivative that inhibits VEGFR-2 and PDGFR BETA RECEPTOR TYROSINE KINASES. It is used as an antineoplastic agent for the treatment of GASTROINTESTINAL STROMAL TUMORS, and for treatment of advanced or metastatic RENAL CELL CARCINOMA.

Year introduced: 2019 (2003)

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Subheadings:

administration and dosage
adverse effects
agonists
analogs and derivatives
analysis
antagonists and inhibitors
blood
cerebrospinal fluid
chemical synthesis

chemistry
classification
economics
history
immunology
isolation and purification
metabolism
pharmacokinetics

pharmacology
poisoning
radiation effects
standards
supply and distribution
therapeutic use
toxicity
urine

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Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D03.383.129.578.823, D03.633.100.473.877

MeSH Unique ID: D000077210

Registry Number: V99T50803M

Entry Terms:

5-(5-Fluoro-2-oxo-1,2-dihydroindolylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
Sunitinib Malate
Sutent
SU 11248
SU011248
SU 011248
SU-011248
SU11248
SU-11248

Pharmacologic Action: