Niemann-Pick C1 Protein
A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.
Year introduced: 2019
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Subheadings:
Tree Number(s): D12.776.157.530.594, D12.776.543.585.594, D12.776.543.750.058.250, D12.776.543.750.830.235, D12.776.624.776.633.250
MeSH Unique ID: D000077296
Entry Terms:
- Niemann Pick C1 Protein
- NPC1 Protein
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