Epidermal Growth Factor
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Year introduced: 2000(1982)
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Subheadings:
Tree Number(s): D06.472.317.350, D12.644.276.382.500, D12.776.467.382.500, D23.529.382.500
MeSH Unique ID: D004815
Registry Number: 62229-50-9
Entry Terms:
- Growth Factor, Epidermal
- Urogastrone
- EGF
- Human Urinary Gastric Inhibitor
- beta-Urogastrone
- beta Urogastrone
- Epidermal Growth Factor-Urogastrone
- Growth Factor-Urogastrone, Epidermal
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