Picrotoxin
A mixture of PICROTOXININ and PICROTIN that is a noncompetitive antagonist at GABA-A receptors acting as a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
Year introduced: 1966
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Subheadings:
Tree Number(s): D02.455.426.392.368.367.800, D02.455.849.765.636, D02.540.552, D20.215.784.500.647, D23.946.649, D26.667.750
MeSH Unique ID: D010852
Registry Number: ZLT174DL7U
Entry Terms:
- 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))-, compd. with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8
- Cocculin
Pharmacologic Action: