GABA Modulators
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Year introduced: 1995
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Subheadings:
Tree Number(s): D27.505.519.625.240.500, D27.505.696.577.240.500
MeSH Unique ID: D018757
Entry Terms:
- Modulators, GABA
- GABAergic Modulators
- Modulators, GABAergic
- gamma-Aminobutyric Acid Modulators
- Acid Modulators, gamma-Aminobutyric
- Modulators, gamma-Aminobutyric Acid
- gamma Aminobutyric Acid Modulators
See Also: