Mice, Inbred MRL lpr
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
Year introduced: 1997
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Subheadings:
Tree Number(s): B01.050.050.199.520.520.555, B01.050.150.900.649.313.992.635.505.500.400.555
MeSH Unique ID: D019463
Entry Terms:
- Mice, MRL lpr
- MRL lpr Mice
- Mouse, MRL lpr
- MRL lpr Mouse
- Mouse, Inbred MRL lpr
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