Receptor, trkA
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
Year introduced: 2000
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Subheadings:
Tree Number(s): D08.811.913.696.620.682.725.400.660, D12.776.476.568.400.660, D12.776.543.750.630.496, D12.776.543.750.750.400.550.550
MeSH Unique ID: D020917
Registry Number: EC 2.7.10.1
Entry Terms:
- trkA Receptor
- Proto-Oncogene Protein trk
- Proto Oncogene Protein trk
- trk, Proto-Oncogene Protein
- gp140(c-TRK)
- trk Proto-Oncogene Protein
- Proto-Oncogene Protein, trk
- trk Proto Oncogene Protein
- Proto-Oncogene Products c-trk
- Proto Oncogene Products c trk
- c-trk, Proto-Oncogene Products
- Receptor, Neurotrophic Tyrosine Kinase Type 1
- c-trk Protein
- c trk Protein
- gp140 c-trk
- c-trk, gp140
- gp140 c trk
- p140-trkA
- p140 trkA
- Neurotrophic Tyrosine Kinase Receptor Type 1
- trk1 Transforming Tryrosine Kinase
- NTRK1 Receptor
- Receptor, NTRK1
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