Receptors, Death Domain

A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.

Year introduced: 2007

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Tree Number(s): D12.776.543.750.690

MeSH Unique ID: D053218

Entry Terms:

• Death Receptors
• Receptors, DR Family
• DR Family Receptors
• Death Domain Receptors
• Death Receptor
• Receptor, Death
• Receptors, Death Domain Family

See Also:

• Receptors, Tumor Necrosis Factor

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Receptors, Cell Surface
Receptors, Death Domain
Edar Receptor
fas Receptor
Receptors, TNF-Related Apoptosis-Inducing Ligand
Receptors, Tumor Necrosis Factor, Member 25
Receptors, Tumor Necrosis Factor, Type I